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Protein Domain : IPR001605

Name  Pleckstrin homology domain, spectrin-type Short Name  PH_dom-spectrin-type
Type  Domain Description  Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane; it associates with band 4.1 and actin to form the cytoskeletal super-structure. The native spectrin molecule is a tetramer comprising two anti-parallel heterodimers joined head to head, such that the C terminus of the alpha-subunit and the N terminus of the beta-subunit are included within the same molecule.Spectrin is similar to alpha-actinin and dystrophin, and contains a pleckstrin homology (PH) domain. The exact function of the PH domain is unknown, but evidence suggests that it contains an electrostatically-polarised pocket that facilitates binding of a ligand (e.g., a peptide). The PH domain contains a number of hydrophobic residues that form a hydrophobic core responsible for protein stability. The spectrin PH domain [], which has the familiar 7-stranded anti-parallel up and down beta-barrel capped by a C-terminal amphiphilic alpha helical cap [], contains insertions that confer 2 additional turns of alpha-helix in the loop between strands 3 and 4. The C-terminal helix is packed into a gorge between strands 1 and 2, and lies parallel to strand 7 [].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PR00683 PRINTS IPR001605

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR016343 Spectrin, beta subunit Spectrin_bsu Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Pleckstrin homology domain, spectrin-type   GO:0005515 protein binding
Pleckstrin homology domain, spectrin-type   GO:0005543 phospholipid binding

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Pleckstrin homology domain, spectrin-type   GO:0005515 protein binding
Pleckstrin homology domain, spectrin-type   GO:0005543 phospholipid binding

1 Parent Features

DB identifier Name Short Name Type
IPR001849 Pleckstrin homology domain Pleckstrin_homology Domain

51 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0112308 A8JR81 Drosophila melanogaster
FBpp0112307 A8JR82 Drosophila melanogaster
FBpp0291397 E2QD55 Drosophila melanogaster
FBpp0074228 Q00963 Drosophila melanogaster
FBpp0089204 Q7KV70 Drosophila melanogaster
FBpp0072934 Q9VZQ3 Drosophila melanogaster
FBpp0089203 Q7KV69 Drosophila melanogaster
FBpp0289294 A8JNJ6 Drosophila melanogaster
FBpp0304366 M9PBL6 Drosophila melanogaster
FBpp0306507 M9PF16 Drosophila melanogaster
FBpp0292409 Q29BD2 Drosophila pseudoobscura
FBpp0292410 I5AN32 Drosophila pseudoobscura
FBpp0273248 Q29JE1 Drosophila pseudoobscura
FBpp0286189 Q29DQ8 Drosophila pseudoobscura
FBpp0162058 B4KYN0 Drosophila mojavensis
FBpp0165522 B4L653 Drosophila mojavensis
FBpp0171462 B4K7P3 Drosophila mojavensis
FBpp0227403 B4LDV2 Drosophila virilis
FBpp0230058 B4MAL4 Drosophila virilis
FBpp0237468 B4M176 Drosophila virilis
FBpp0255325 B4PMC3 Drosophila yakuba
FBpp0262686 B4Q2I9 Drosophila yakuba
FBpp0266370 B4PGP9 Drosophila yakuba
A8Y467_CAEBR A8Y467 Caenorhabditis briggsae
A8XUM5_CAEBR A8XUM5 Caenorhabditis briggsae
B0K089_CAEBR B0K089 Caenorhabditis briggsae
A8XI29_CAEBR A8XI29 Caenorhabditis briggsae
H2VSP1_CAEJA H2VSP1 Caenorhabditis japonica
H2W527_CAEJA H2W527 Caenorhabditis japonica
G0NGX8_CAEBE G0NGX8 Caenorhabditis brenneri