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Protein Domain : IPR002404

Name  Insulin receptor substrate-1, PTB Short Name  Insln_rcpt_S1
Type  Domain Description  Insulin receptor substrate-1 proteins contain both a pleckstrin homologydomain () and a phosphotyrosine binding (PTB) domain. These domains facilitate interaction with the activated tyrosine-phosphorylated insulin receptor.The PTB domain is situated towards the N terminus. Two arginines in this domain are responsible forhydrogen bonding phosphotyrosine residues on a Ac-LYASSNPApY-NH2 peptidein the juxtamembrane region of the insulin receptor. Further interactionsvia `bridged' water molecules are coordinated by residues an Asn and a Ser residue[].The PTB domain has a compact, 7-stranded beta-sandwich structure, capped bya C-terminal helix. The substrate peptide fits into an L-shaped surfacecleft formed from the C-terminal helix and strands 5 and 6 [].

Publication Counts Displayer

0 Child Features

0 Contains

4 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF02174 PFAM IPR002404
PR00628 PRINTS IPR002404
PS51064 PROFILE IPR002404
SM00310 SMART IPR002404

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Insulin receptor substrate-1, PTB   GO:0005158 insulin receptor binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Insulin receptor substrate-1, PTB   GO:0005158 insulin receptor binding

1 Parent Features

DB identifier Name Short Name Type
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain

49 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0079315 Q9VLL4 Drosophila melanogaster
FBpp0079677 Q9XTN2 Drosophila melanogaster
FBpp0071008 Q9W3R6 Drosophila melanogaster
FBpp0293740 Q9VSL8 Drosophila melanogaster
FBpp0293741 M9NDM3 Drosophila melanogaster
FBpp0305319 M9PBW9 Drosophila melanogaster
FBpp0305320 M9PEJ8 Drosophila melanogaster
FBpp0305321 M9PF06 Drosophila melanogaster
FBpp0277245 Q29FI8 Drosophila pseudoobscura
FBpp0275060 Q29GA7 Drosophila pseudoobscura
FBpp0279437 Q29P01 Drosophila pseudoobscura
FBpp0159878 B4KHN6 Drosophila mojavensis
FBpp0162125 B4KZ53 Drosophila mojavensis
FBpp0165162 B4L2C7 Drosophila mojavensis
FBpp0166457 B4KKH4 Drosophila mojavensis
FBpp0227466 B4LEJ9 Drosophila virilis
FBpp0229268 B4MEN8 Drosophila virilis
FBpp0229339 B4MG31 Drosophila virilis
FBpp0232416 B4M925 Drosophila virilis
FBpp0255998 B4NWZ3 Drosophila yakuba
FBpp0260719 B4Q128 Drosophila yakuba
FBpp0265762 B4PG07 Drosophila yakuba
FBpp0271295 B4NZ70 Drosophila yakuba
A8X3J3_CAEBR A8X3J3 Caenorhabditis briggsae
A8Y1N6_CAEBR A8Y1N6 Caenorhabditis briggsae
K7HYS4_CAEJA K7HYS4 Caenorhabditis japonica
H2W807_CAEJA H2W807 Caenorhabditis japonica
G0MNX4_CAEBE G0MNX4 Caenorhabditis brenneri
G0NWA9_CAEBE G0NWA9 Caenorhabditis brenneri
G5EGK1_CAEEL G5EGK1 Caenorhabditis elegans