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Protein Domain : IPR010569

Name  Myotubularin-like phosphatase domain Short Name  Myotubularin-like_Pase_dom
Type  Domain Description  This entry represents the phosphatase domain within eukaryotic myotubularin-related proteins. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate []. Mutations in gene encoding myotubularin-related proteins have been associated with disease [].Myotubularin phosphatases are members of the protein tyrosine phosphatase (PTP) superfamily. The PTP domain is found in a diverse group of enzymes that catalyse phosphoester hydrolysis using a cysteine nucleophile and an arginine residue that binds to oxygen atoms of the phosphate. These two catalytically essential residues are found in a Cys-x(5)-Arg motif, which is a hallmark of PTP domains. The PTP superfamily of enzymes includes tyrosine-specific, dual specificity, low molecular weight, and Cdc25 phosphatases. All of these enzymes utilise phosphoproteins as substrates. Unlike these members of PTPs, enzymes that contain the tensin and myotubularin PTP domain utilise the phosphoinositide as its physiologic substrate. Myotubularins are 3-phosphatases specific for membrane-embedded PtdIns3P and PtdIns(3,5)P2, two PIs that function within the endosomal-lysosomal pathway [, ].The myotubularin phosphatase domain consists of a central seven stranded beta sheet flanked by thirteen alpha helices []. Although its core structure is similar to that of other PTP superfamily members, the myotubularin phosphatase domain is much larger. It contains an extra C-terminal region, which could be implicated in protein-protein interactions. The active site motif forms a P-loop at the base of a substrate binding pocket that is characteristic of PTP domains. This pocket is significantly deeper than that of other PTP pockets, which could explain the difference in substrate specificity.

Publication Counts Displayer

0 Child Features

0 Contains

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF06602 PFAM IPR010569
PS51339 PROFILE IPR010569

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Myotubularin-like phosphatase domain   GO:0016791 phosphatase activity
Myotubularin-like phosphatase domain   GO:0016311 dephosphorylation

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Myotubularin-like phosphatase domain   GO:0016791 phosphatase activity
Myotubularin-like phosphatase domain   GO:0016311 dephosphorylation

1 Parent Features

DB identifier Name Short Name Type
IPR029021 Protein-tyrosine phosphatase-like Prot-tyrosine_phosphatase-like Domain

85 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0073764 Q9VY15 Drosophila melanogaster
FBpp0086114 Q9NDR1 Drosophila melanogaster
FBpp0071938 Q8MLR7 Drosophila melanogaster
FBpp0071937 Q9W1Q6 Drosophila melanogaster
FBpp0082003 Q9VGH9 Drosophila melanogaster
FBpp0082004 Q7KSP6 Drosophila melanogaster
FBpp0076242 Q8SZY7 Drosophila melanogaster
FBpp0078854 Q9VMI9 Drosophila melanogaster
FBpp0111853 Q7KK51 Drosophila melanogaster
FBpp0111901 Q7YU03 Drosophila melanogaster
FBpp0111902 A8JV04 Drosophila melanogaster
FBpp0288263 Q29F44 Drosophila pseudoobscura
FBpp0308895 B5DNM0 Drosophila pseudoobscura
FBpp0273491 Q29IT4 Drosophila pseudoobscura
FBpp0276823 Q291H1 Drosophila pseudoobscura
FBpp0308120 N6WBS1 Drosophila pseudoobscura
FBpp0277980 Q28ZJ4 Drosophila pseudoobscura
FBpp0279219 Q29PM8 Drosophila pseudoobscura
FBpp0284675 Q294Z3 Drosophila pseudoobscura
FBpp0159518 B4KE12 Drosophila mojavensis
FBpp0160505 B4KGH4 Drosophila mojavensis
FBpp0163040 B4KVN6 Drosophila mojavensis
FBpp0165343 B4L6R3 Drosophila mojavensis
FBpp0168241 B4KSF0 Drosophila mojavensis
FBpp0170247 B4KQZ4 Drosophila mojavensis
FBpp0224571 B4M4W2 Drosophila virilis
FBpp0226107 B4LEV8 Drosophila virilis
FBpp0226891 B4LR85 Drosophila virilis
FBpp0230821 B4M7Q5 Drosophila virilis
FBpp0232925 B4MG90 Drosophila virilis