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Protein Domain : IPR001353

Name  Proteasome, subunit alpha/beta Short Name  Proteasome_sua/b
Type  Family Description  ATP-dependent protease complexes are present in all three kingdoms of life, where they rid the cell of misfolded or damaged proteins and control the level of certain regulatory proteins. They include the proteasome in Eukaryotes, Archaea, and Actinomycetales and the HslVU (ClpQY, clpXP) complex in other eubacteria. Genes homologues to eubacterial HslU (ClpY, clpX) have also been demonstrated in to be present in the genome of trypanosomatid protozoa [].The proteasome (or macropain) () [, , , , ]is a eukaryotic andarchaeal multicatalytic proteinase complex that seems to be involved inan ATP/ubiquitin-dependent nonlysosomal proteolytic pathway. In eukaryotes theproteasome is composed of about 28 distinct subunits which form a highlyordered ring-shaped structure (20S ring) of about 700 kDa.Most proteasome subunits can be classified on the basis of sequence similarities into two groups, alpha (A) and beta (B).The prokaryotic ATP-dependent proteasome is coded for by the heat-shock locus VU (HslVU). It consists of HslV, a peptidase, and HslU (), the ATPase and chaperone belonging to the AAA/Clp/Hsp100 family. The crystal structure of Thermotoga maritimaHslV has been determined to 2.1-A resolution. The structure of the dodecameric enzyme is well conserved compared to those from Escherichia coliand Haemophilus influenzae[, ].This entry contains threonine peptidases and non-peptidase homologues belong to MEROPS peptidase family T1 (proteasome family, clan PB(T)). The family consists of the protease components of the archaeal and bacterial proteasomes and the alpha and beta subunits of the eukaryotic proteasome.

Publication Counts Displayer

3 Child Features

DB identifier Name Short Name Type
IPR023332 Proteasome A-type subunit Proteasome_suA-type Family
IPR023333 Proteasome B-type subunit Proteasome_suB-type Family
IPR022281 ATP-dependent protease, HslV subunit ATP-dep_Prtase_HsIV_su Family

1 Contains

DB identifier Name Short Name Type
IPR016050 Proteasome beta-type subunit, conserved site Proteasome_bsu_CS Conserved_site

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00227 PFAM IPR001353

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Proteasome, subunit alpha/beta   GO:0004298 threonine-type endopeptidase activity
Proteasome, subunit alpha/beta   GO:0051603 proteolysis involved in cellular protein catabolic process
Proteasome, subunit alpha/beta   GO:0005839 proteasome core complex

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Proteasome, subunit alpha/beta   GO:0004298 threonine-type endopeptidase activity
Proteasome, subunit alpha/beta   GO:0051603 proteolysis involved in cellular protein catabolic process
Proteasome, subunit alpha/beta   GO:0005839 proteasome core complex

0 Parent Features

250 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0081488 Q9XYN7 Drosophila melanogaster
FBpp0082062 P40301 Drosophila melanogaster
FBpp0071451 P18053 Drosophila melanogaster
FBpp0080490 Q9VJJ0 Drosophila melanogaster
FBpp0075119 P40304 Drosophila melanogaster
FBpp0071954 Q9W1S5 Drosophila melanogaster
FBpp0083336 Q24178 Drosophila melanogaster
FBpp0080028 Q9VK14 Drosophila melanogaster
FBpp0085100 Q9VA12 Drosophila melanogaster
FBpp0089041 Q9V5C6 Drosophila melanogaster
FBpp0080578 Q8INY4 Drosophila melanogaster
FBpp0079538 P12881 Drosophila melanogaster
FBpp0086066 Q95083 Drosophila melanogaster
FBpp0087320 Q7K148 Drosophila melanogaster
FBpp0071960 Q0E8X9 Drosophila melanogaster
FBpp0075382 Q9VUJ1 Drosophila melanogaster
FBpp0087968 Q9XZJ4 Drosophila melanogaster
FBpp0072257 Q27575 Drosophila melanogaster
FBpp0086400 A0AQH0 Drosophila melanogaster
FBpp0078449 Q9VNA5 Drosophila melanogaster
FBpp0078473 Q8T915 Drosophila melanogaster
FBpp0073989 P22769 Drosophila melanogaster
FBpp0077381 Q8T8U1 Drosophila melanogaster
FBpp0077383 Q9VQE5 Drosophila melanogaster
FBpp0070782 Q9W470 Drosophila melanogaster
FBpp0274758 Q2M187 Drosophila pseudoobscura
FBpp0281088 B5DWY5 Drosophila pseudoobscura
FBpp0282683 B5DYT1 Drosophila pseudoobscura
FBpp0286388 Q29EG7 Drosophila pseudoobscura
FBpp0287416 Q29KI2 Drosophila pseudoobscura