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Protein Domain : IPR029055

Name  Nucleophile aminohydrolases, N-terminal Short Name  Ntn_hydrolases_N
Type  Domain Description  The N-terminal of the nucleophile aminohydrolase (Ntn hydrolases) provides two catalytic groups, nucleophile and proton donor. Ntn hydrolases use the side chain of the amino-terminal residue, incorporated in a beta-sheet, as the nucleophile in the catalytic attack at the carbonyl carbon. The nucleophile is cysteine in GAT, serine in penicillin acylase, and threonine in the proteasome. All the enzymes share an unusual fold in which the nucleophile and other catalytic groups occupy equivalent sites. This fold provides both the capacity for nucleophilic attack and the possibility of autocatalytic processing []. Proteins containing this domain include:Class II glutamine amidotransferases. Penicillin acylases. Penicillin V acylases. Proteasome subunits. (Glycosyl)asparaginases. Gamma-glutamyltranspeptidase-like proteins. SPO2555-like proteins.

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR017932 Glutamine amidotransferase type 2 domain GATase_2_dom Domain
IPR015230 Carbapenam-3-carboxylate synthase, N-terminal CarA_N Domain

0 Contains

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
G3DSA:3.60.20.10 GENE3D IPR029055
SSF56235 SSF IPR029055

2 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

458 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0085745 A1ZBI7 Drosophila melanogaster
FBpp0081488 Q9XYN7 Drosophila melanogaster
FBpp0082062 P40301 Drosophila melanogaster
FBpp0071451 P18053 Drosophila melanogaster
FBpp0080490 Q9VJJ0 Drosophila melanogaster
FBpp0075119 P40304 Drosophila melanogaster
FBpp0071954 Q9W1S5 Drosophila melanogaster
FBpp0083336 Q24178 Drosophila melanogaster
FBpp0071652 Q9W2C3 Drosophila melanogaster
FBpp0089009 Q7KTW9 Drosophila melanogaster
FBpp0308484 Q8MR45 Drosophila melanogaster
FBpp0073423 Q9VYR2 Drosophila melanogaster
FBpp0084666 Q9VAW3 Drosophila melanogaster
FBpp0080028 Q9VK14 Drosophila melanogaster
FBpp0085100 Q9VA12 Drosophila melanogaster
FBpp0075100 Q9VVA4 Drosophila melanogaster
FBpp0289202 Q5LJP9 Drosophila melanogaster
FBpp0089041 Q9V5C6 Drosophila melanogaster
FBpp0080578 Q8INY4 Drosophila melanogaster
FBpp0081261 Q27601 Drosophila melanogaster
FBpp0079538 P12881 Drosophila melanogaster
FBpp0086066 Q95083 Drosophila melanogaster
FBpp0087320 Q7K148 Drosophila melanogaster
FBpp0071960 Q0E8X9 Drosophila melanogaster
FBpp0075382 Q9VUJ1 Drosophila melanogaster
FBpp0074110 Q7KUX2 Drosophila melanogaster
FBpp0074111 Q9VXA5 Drosophila melanogaster
FBpp0087968 Q9XZJ4 Drosophila melanogaster
FBpp0073861 Q9VXT7 Drosophila melanogaster
FBpp0076655 Q9VRZ1 Drosophila melanogaster