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Protein Domain : IPR025661

Name  Cysteine peptidase, asparagine active site Short Name  Pept_asp_AS
Type  Active_site Description  Thiol (cysteine) proteases (EC 3.4.22.-) []are a family of proteolytic enzymes which contain an active site cysteine. Catalysis proceeds through a thioester intermediate and is facilitated by a nearby histidine side chain; an asparagine completes the essential catalytic triad.Cysteine peptidases have characteristic molecular topologies, which can be seen not only in their three-dimensional structures, but commonly also in the two-dimensional structures. These are peptidases in which the nucleophile is the sulphydryl groupof a cysteine residue. Cysteine proteases are divided into clans (proteins which are evolutionary related), and further sub-divided into families, on the basis of the architecture of their catalytic dyad (cysteine-histidene) or triad [].Modification of the catalytic triad, especially of its first amino acid (cysteine), has been postulated as a suitable target for a chemical modulation of enzyme function. This is the case for silicateins, where the cysteine residue has been replaced by a serine []. Silicateins represent a group of enzymes possessing bi-functional activity; in addition to the silica-condensing activity, they possess a proteolytic (cathepsin-like) activity [].The sequences around the three active site residues are well conserved. This entry represents the asparagine active site. The catalytic triad consists of this entry, and . This catalytic triad detects mainly proteases of the C1 family, including papain and several cathepsins.

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0 Child Features

0 Contains

1 Cross References

Source . Name

Subject . Primary Identifier
PS00640 PROSITE IPR025661

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

149 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086719 Q95029 Drosophila melanogaster
FBpp0075508 Q9V3U6 Drosophila melanogaster
FBpp0078465 Q9VN93 Drosophila melanogaster
FBpp0078464 H5V8F3 Drosophila melanogaster
FBpp0086091 A1ZAU4 Drosophila melanogaster
FBpp0086090 Q7K5N8 Drosophila melanogaster
FBpp0073669 Q9VY87 Drosophila melanogaster
FBpp0071697 Q7JWQ7 Drosophila melanogaster
FBpp0278474 Q28XS2 Drosophila pseudoobscura
FBpp0275168 Q2M011 Drosophila pseudoobscura
FBpp0274400 B5DPR9 Drosophila pseudoobscura
FBpp0277631 Q291G0 Drosophila pseudoobscura
FBpp0284278 Q29HU8 Drosophila pseudoobscura
FBpp0300603 I5APD1 Drosophila pseudoobscura
FBpp0284455 B5DY59 Drosophila pseudoobscura
FBpp0278526 Q28XK9 Drosophila pseudoobscura
FBpp0306123 N6VFP6 Drosophila pseudoobscura
FBpp0159433 B4KCM1 Drosophila mojavensis
FBpp0160847 B4L168 Drosophila mojavensis
FBpp0164720 B4L388 Drosophila mojavensis
FBpp0167804 B4KQX9 Drosophila mojavensis
FBpp0168256 B4KRY5 Drosophila mojavensis
FBpp0170067 B4KNQ5 Drosophila mojavensis
FBpp0170422 B4KTB9 Drosophila mojavensis
FBpp0233679 B4M3R5 Drosophila virilis
FBpp0225434 B4M4X6 Drosophila virilis
FBpp0225729 B4LC35 Drosophila virilis
FBpp0227971 B4LDM9 Drosophila virilis
FBpp0235002 B4LM55 Drosophila virilis
FBpp0234423 B4LLV9 Drosophila virilis