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Protein Domain : IPR009038

Name  GOLD Short Name  GOLD
Type  Domain Description  The GOLD (for Golgi dynamics) domain is a protein module found in severaleukaryotic Golgi and lipid-traffic proteins. It is typically between 90 and150 amino acids long. Most of the size difference observed in the GOLD-domainsuperfamily is traceable to a single large low-complexity insert that is seenin some versions of the domain. With the exception of the p24 proteins, whichhave a simple architecture with the GOLD domain as their only globular domain, all other GOLD-domain proteins contain additional conserved globular domains. In these proteins, the GOLD domain co-occurs with lipid-, sterol- or fatty acid-binding domains such as PH, CRAL-TRIO, FYVE oxysterol binding- and acyl CoA-bindingdomains, suggesting that these proteins may interact with membranes. The GOLDdomain can also be found associated with a RUN domain, whichmay have a role in the interaction of various proteins with cytoskeletalfilaments. The GOLD domain is predicted to mediate diverse protein-proteininteractions []. A secondary structure prediction for the GOLD domain reveals that it is likelyto adopt a compact all-beta-fold structure with six to seven strands. Most ofthe sequence conservation is centred on the hydrophobic cores that supportthese predicted strands. The predicted secondary-structure elements and thesize of the conserved core of the domain suggests that it may form a beta-sandwich fold with the strands arranged in two beta sheets stacked on eachother [].Some proteins known to contain a GOLD domain are listed below:Eukaryotic proteins of the p24 family.Animal Sec14-like proteins. They are involved in secretion.Human Golgi resident protein GCP60. It interacts with the Golgi integralmembrane protein Giantin.Yeast oxysterol-binding protein homologue 3 (OSH3).

Publication Counts Displayer

0 Child Features

0 Contains

4 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF01105 PFAM IPR009038
PF13897 PFAM IPR009038
PS50866 PROFILE IPR009038
SSF101576 SSF IPR009038

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

2 Found In

DB identifier Name Short Name Type
IPR015720 TMP21-related TMP21-related Family
IPR015718 Transmembrane emp24 domain-containing protein 7 TMED7 Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
GOLD   GO:0006810 transport
GOLD   GO:0016021 integral component of membrane

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
GOLD   GO:0006810 transport
GOLD   GO:0016021 integral component of membrane

0 Parent Features

163 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0084133 Q8SXY6 Drosophila melanogaster
FBpp0309375 Q9VXY9 Drosophila melanogaster
FBpp0081576 Q9I7K5 Drosophila melanogaster
FBpp0301157 Q9VWD5 Drosophila melanogaster
FBpp0072461 Q8SYC4 Drosophila melanogaster
FBpp0071663 Q9W2A6 Drosophila melanogaster
FBpp0080608 Q8INX8 Drosophila melanogaster
FBpp0078902 Q9VMD6 Drosophila melanogaster
FBpp0302983 M9PB50 Drosophila melanogaster
FBpp0070643 Q9W4K0 Drosophila melanogaster
FBpp0073441 Q9VYT6 Drosophila melanogaster
FBpp0081571 Q86BA5 Drosophila melanogaster
FBpp0290661 Q9VRU2 Drosophila melanogaster
FBpp0272719 Q29II3 Drosophila pseudoobscura
FBpp0287747 Q29HE8 Drosophila pseudoobscura
FBpp0274230 Q2LZD7 Drosophila pseudoobscura
FBpp0281298 Q295B2 Drosophila pseudoobscura
FBpp0277839 Q29FF8 Drosophila pseudoobscura
FBpp0278501 Q28XP5 Drosophila pseudoobscura
FBpp0280553 Q29MH6 Drosophila pseudoobscura
FBpp0301088 B5DVX0 Drosophila pseudoobscura
FBpp0284500 Q29HY1 Drosophila pseudoobscura
FBpp0285826 Q29JQ0 Drosophila pseudoobscura
FBpp0286946 Q29HN2 Drosophila pseudoobscura
FBpp0159361 B4KB41 Drosophila mojavensis
FBpp0160232 B4L801 Drosophila mojavensis
FBpp0161829 B4KWP9 Drosophila mojavensis
FBpp0164408 B4L2G0 Drosophila mojavensis
FBpp0164580 B4L245 Drosophila mojavensis
FBpp0164584 B4L249 Drosophila mojavensis