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Protein Domain : IPR016130

Name  Protein-tyrosine phosphatase, active site Short Name  Tyr_Pase_AS
Type  Active_site Description  This entry includes proteins of two subfamilies: Ser/Thr () and Tyr dual specificity protein phosphatase and tyrosine specific protein phosphatase (). Both of these subfamilies may also have inactive phosphatase domains, and dependent on the domain composition this loss of catalytic activity has different effects on protein function. Inactive single domain phosphatases can still specifically bind substrates, and protect against dephosphorylation, while the inactive domains of tandem phosphatases can be further subdivided into two classes. Those which bind phosphorylated tyrosine residues may recruit multi-phosphorylated substrates for the adjacent active domains and are more conserved, while the other class have accumulated several variable amino acid substitutions and have a complete loss of tyrosine binding capability. The second class shows a release of evolutionary constraint for the sites around the catalytic centre, which emphasises a difference in function from the first group. There is a region of higher conservation common to both classes, suggesting a regulatory centre [].Ser/Thr and Tyr dual specificity phosphatases are a group of enzymes with both Ser/Thr () and tyrosine specific proteinphosphatase () activity able to remove both the serine/threonine or tyrosine-bound phosphate group from a widerange of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase. Dual specificity protein phosphatases (DSPs) regulate mitogenic signal transduction and control the cell cycle. Tyrosine specific protein phosphatases catalyze the removal of a phosphate group attached to a tyrosine residue. They are also very important in the control of cell growth, proliferation, differentiation and transformation.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS00383 PROSITE IPR016130

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

16 Found In

DB identifier Name Short Name Type
IPR000387 Protein-tyrosine/Dual specificity phosphatase Tyr/Dual-sp_Pase Domain
IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type Tyr_Pase_rcpt/non-rcpt Domain
IPR000340 Dual specificity phosphatase, catalytic domain Dual-sp_phosphatase_cat-dom Domain
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain Dual-sp_phosphatase_subgr_cat Domain
IPR012151 Protein-tyrosine phosphatase, non-receptor type-3, -4 Tyr_Pase_non-rcpt_typ-3/4 Family
IPR020417 Atypical dual specificity phosphatase Atypical_DUSP Family
IPR020405 Atypical dual specificity phosphatase, subfamily A Atypical_DUSP_famA Family
IPR003595 Protein-tyrosine phosphatase, catalytic Tyr_Pase_cat Domain
IPR012152 Protein-tyrosine phosphatase, non-receptor type-6, -11 Tyr_Pase_non-rcpt_typ-6/11 Family
IPR014392 Protein-tyrosine phosphatase, non-receptor type-14, -21 Tyr_Pase_non-rcpt_typ-14/21 Family
IPR003546 Type III secreted modular tyrosine phosphatase, SptP/YopH Tyr_Pase_SptP/YopH Family
IPR008356 Protein-tyrosine phosphatase, KIM-containing Tyr_Pase_KIM-con Family
IPR020428 Protein-tyrosine phosphatase, dual specificity phosphatase, eukaryotic Tyr_Pase_dualsp-Pase_euk Family
IPR012266 Protein-tyrosine phosphatase, non-receptor type-12 Ptpn_12 Family
IPR012265 Protein-tyrosine phosphatase, non-receptor type-1/2 Ptpn1/Ptpn2 Family
IPR020420 Atypical dual specificity phosphatase, subfamily B Atypical_DUSP_famB Family

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Protein-tyrosine phosphatase, active site   GO:0004725 protein tyrosine phosphatase activity
Protein-tyrosine phosphatase, active site   GO:0016791 phosphatase activity
Protein-tyrosine phosphatase, active site   GO:0016311 dephosphorylation

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Protein-tyrosine phosphatase, active site   GO:0004725 protein tyrosine phosphatase activity
Protein-tyrosine phosphatase, active site   GO:0016791 phosphatase activity
Protein-tyrosine phosphatase, active site   GO:0016311 dephosphorylation

0 Parent Features

543 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0099554 Q9W323 Drosophila melanogaster
FBpp0099555 Q9W324 Drosophila melanogaster
FBpp0099556 Q8IRM7 Drosophila melanogaster
FBpp0099558 Q8IRM6 Drosophila melanogaster
FBpp0099559 Q59E68 Drosophila melanogaster
FBpp0074510 Q9VWF4 Drosophila melanogaster
FBpp0074420 Q9VWN2 Drosophila melanogaster
FBpp0111917 A8JUQ2 Drosophila melanogaster
FBpp0083844 Q86BN8 Drosophila melanogaster
FBpp0086114 Q9NDR1 Drosophila melanogaster
FBpp0071938 Q8MLR7 Drosophila melanogaster
FBpp0071937 Q9W1Q6 Drosophila melanogaster
FBpp0070363 L7XAI0 Drosophila melanogaster
FBpp0290828 Q6NN85 Drosophila melanogaster
FBpp0087183 Q8SX38 Drosophila melanogaster
FBpp0072602 Q9W0G1 Drosophila melanogaster
FBpp0072603 Q8IRH4 Drosophila melanogaster
FBpp0080801 P16621 Drosophila melanogaster
FBpp0290827 E1JIW2 Drosophila melanogaster
FBpp0073369 P35992 Drosophila melanogaster
FBpp0303823 M9PEB6 Drosophila melanogaster
FBpp0303420 M9PJI5 Drosophila melanogaster
FBpp0071603 Q9W2F3 Drosophila melanogaster
FBpp0078914 Q9V3V3 Drosophila melanogaster
FBpp0075645 P16620 Drosophila melanogaster
FBpp0081288 Q9VHV8 Drosophila melanogaster
FBpp0070692 Q9W4F5 Drosophila melanogaster
FBpp0070693 Q8IRS0 Drosophila melanogaster
FBpp0080614 Q9VJ95 Drosophila melanogaster
FBpp0310132 E1JJE4 Drosophila melanogaster