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Protein Domain : IPR024936

Name  Cyclophilin-type peptidyl-prolyl cis-trans isomerase Short Name  Cyclophilin-type_PPIase
Type  Family Description  Cyclophilins exhibit peptidyl-prolyl cis-trans isomerase (PPIase) activity (), accelerating protein folding by catalysing the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides [, ]. They also have protein chaperone-like functions []and are the major high-affinity binding proteins for the immunosuppressive drug cyclosporin A (CSA) in vertebrates [].Cyclophilins are found in all prokaryotes and eukaryotes, and have been structurally conserved throughout evolution, implying their importance in cellular function []. They share a common 109 amino acid cyclophilin-like domain (CLD) and additional domains unique to each member of the family. The CLD domain contains the PPIase activity, while the unique domains are important for selection of protein substrates and subcellular compartmentalisation [].This entry represents the cyclophilin-type peptidyl-prolyl cis-trans isomerase family.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF001467 PIRSF IPR024936

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Cyclophilin-type peptidyl-prolyl cis-trans isomerase   GO:0003755 peptidyl-prolyl cis-trans isomerase activity
Cyclophilin-type peptidyl-prolyl cis-trans isomerase   GO:0006457 protein folding

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Cyclophilin-type peptidyl-prolyl cis-trans isomerase   GO:0003755 peptidyl-prolyl cis-trans isomerase activity
Cyclophilin-type peptidyl-prolyl cis-trans isomerase   GO:0006457 protein folding

0 Parent Features

87 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0075479 Q7K2I4 Drosophila melanogaster
FBpp0071844 Q9W227 Drosophila melanogaster
FBpp0085477 Q4V5H1 Drosophila melanogaster
FBpp0087366 Q8MKJ6 Drosophila melanogaster
FBpp0072463 Q9W0Q2 Drosophila melanogaster
FBpp0275990 Q28XI4 Drosophila pseudoobscura
FBpp0277158 Q292Z8 Drosophila pseudoobscura
FBpp0277873 Q29FF4 Drosophila pseudoobscura
FBpp0276013 Q28XM2 Drosophila pseudoobscura
FBpp0162831 B4L0G5 Drosophila mojavensis
FBpp0162913 B4L199 Drosophila mojavensis
FBpp0162915 B4L1A2 Drosophila mojavensis
FBpp0163284 B4L788 Drosophila mojavensis
FBpp0168552 B4KN39 Drosophila mojavensis
FBpp0169220 B4KTE5 Drosophila mojavensis
FBpp0169457 B4KNJ0 Drosophila mojavensis
FBpp0170972 B4L5M3 Drosophila mojavensis
FBpp0171916 B4K9T8 Drosophila mojavensis
FBpp0233550 B4M328 Drosophila virilis
FBpp0228368 B4LIG1 Drosophila virilis
FBpp0228454 B4LC72 Drosophila virilis
FBpp0228455 B4LC74 Drosophila virilis
FBpp0234609 B4LK03 Drosophila virilis
FBpp0235669 B4LMM9 Drosophila virilis
FBpp0236630 B4LKL8 Drosophila virilis
FBpp0237844 B4LXL5 Drosophila virilis
FBpp0256861 B4P5I3 Drosophila yakuba
FBpp0266027 B4PC71 Drosophila yakuba
FBpp0267018 B4PI11 Drosophila yakuba
FBpp0269631 B4P0Z5 Drosophila yakuba