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Protein Domain : IPR001054

Name  Adenylyl cyclase class-3/4/guanylyl cyclase Short Name  A/G_cyclase
Type  Domain Description  Guanylate cyclases () catalyse the formation of cyclic GMP (cGMP) from GTP. cGMP acts as an intracellular messenger, activating cGMP-dependent kinases and regulating cGMP-sensitive ion channels. The role of cGMP as a second messenger in vascular smooth muscle relaxation and retinal photo-transduction is well established. Guanylate cyclase is found both in thesoluble and particulate fractions of eukaryotic cells. The soluble and plasmamembrane-bound forms differ in structure, regulation and other properties [,, , ]. Most currently known plasma membrane-boundforms are receptors for small polypeptides. The soluble forms of guanylate cyclase arecytoplasmic heterodimers having alpha and beta subunits.In all characterised eukaryote guanylyl- and adenylyl cyclases, cyclic nucleotide synthesis is carried out by the conserved class III cyclase domain.

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site A/G_cyclase_CS Conserved_site

5 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00211 PFAM IPR001054
PS50125 PROFILE IPR001054
SM00044 SMART IPR001054
G3DSA:3.30.70.1230 GENE3D IPR001054
SSF55073 SSF IPR001054

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

1 Found In

DB identifier Name Short Name Type
IPR016577 Adenylate cylcase, type 10 Adenylate_cylcase_typ10 Family

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Adenylyl cyclase class-3/4/guanylyl cyclase   GO:0016849 phosphorus-oxygen lyase activity
Adenylyl cyclase class-3/4/guanylyl cyclase   GO:0009190 cyclic nucleotide biosynthetic process
Adenylyl cyclase class-3/4/guanylyl cyclase   GO:0035556 intracellular signal transduction

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Adenylyl cyclase class-3/4/guanylyl cyclase   GO:0016849 phosphorus-oxygen lyase activity
Adenylyl cyclase class-3/4/guanylyl cyclase   GO:0009190 cyclic nucleotide biosynthetic process
Adenylyl cyclase class-3/4/guanylyl cyclase   GO:0035556 intracellular signal transduction

0 Parent Features

393 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0082745 Q9VEU5 Drosophila melanogaster
FBpp0099930 Q2PDU2 Drosophila melanogaster
FBpp0079994 Q9VK53 Drosophila melanogaster
FBpp0099492 Q9VXU0 Drosophila melanogaster
FBpp0290537 Q8IRF5 Drosophila melanogaster
FBpp0271905 Q9W2P1 Drosophila melanogaster
FBpp0271904 Q8MLX0 Drosophila melanogaster
FBpp0099611 A1ZB47 Drosophila melanogaster
FBpp0291487 Q7JQ32 Drosophila melanogaster
FBpp0084819 Q07093 Drosophila melanogaster
FBpp0073809 P32870 Drosophila melanogaster
FBpp0082641 Q9VF17 Drosophila melanogaster
FBpp0079995 Q9VK52 Drosophila melanogaster
FBpp0074666 Q9VW60 Drosophila melanogaster
FBpp0293332 M9NFA6 Drosophila melanogaster
FBpp0079996 Q9VK51 Drosophila melanogaster
FBpp0085252 Q9V9R3 Drosophila melanogaster
FBpp0072753 Q9W038 Drosophila melanogaster
FBpp0085115 Q9VA09 Drosophila melanogaster
FBpp0293331 C7LAF5 Drosophila melanogaster
FBpp0110263 Q9VEU6 Drosophila melanogaster
FBpp0291649 Q8IQK2 Drosophila melanogaster
FBpp0291650 Q9VU79 Drosophila melanogaster
FBpp0305810 M9PHL3 Drosophila melanogaster
FBpp0309409 M9PJN1 Drosophila melanogaster
FBpp0305812 M9PEL4 Drosophila melanogaster
FBpp0305813 M9PH52 Drosophila melanogaster
FBpp0110261 Q0KI72 Drosophila melanogaster
FBpp0290535 E1JIB3 Drosophila melanogaster
FBpp0290536 Q9W037 Drosophila melanogaster