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Protein Domain : IPR001478

Name  PDZ domain Short Name  PDZ
Type  Domain Description  PDZ domains (also known as Discs-large homologous regions (DHR) or GLGF)) are found in diverse signalling proteins in bacteria, yeasts, plants, insects and vertebrates [, ]. PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences []. In most cases, interaction between a PDZ domain and its target is constitutive, with a binding affinity of 1 to 10 microns. However, agonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane, a compartment where high concentrations of phosphatidylinositol 4,5-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin, CASK, Tiam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (beta-A to beta-F) and two alpha-helices, A and B, compactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an anti-parallel beta-strand interacts with the beta-B strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the beta-A and beta-B strands.

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR024958 GRASP55/65 PDZ-like domain GRASP55/65_PDZ Domain
IPR029414 Tricorn protease, PDZ domain Tricorn_PDZ Domain

0 Contains

6 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00595 PFAM IPR001478
PF13180 PFAM IPR001478
PS50106 PROFILE IPR001478
SM00228 SMART IPR001478
G3DSA:2.30.42.10 GENE3D IPR001478
SSF50156 SSF IPR001478

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

29 Found In

DB identifier Name Short Name Type
IPR008339 Dishevelled family Dishevelled_fam Family
IPR015506 Dishevelled-related protein Dsh/Dvl-rel Family
IPR012151 Protein-tyrosine phosphatase, non-receptor type-3, -4 Tyr_Pase_non-rcpt_typ-3/4 Family
IPR015482 Syntrophin Syntrophin Family
IPR016313 Disks large 1 DLG1 Family
IPR008915 Peptidase M50 Peptidase_M50 Domain
IPR017268 Tax1-binding protein 3 Tax1-binding_p3 Family
IPR001940 Peptidase S1C Peptidase_S1C Family
IPR017379 Uncharacterised conserved protein UCP038083, PDZ UCP038083_PDZ Family
IPR017365 Lin-7 homologue Lin-7_homologue Family
IPR015483 Gamma 1 syntrophin Syntrophin_gamma Family
IPR012153 Protein-tyrosine phosphatase, non-receptor type-13 Tyr_Pase_non-rcpt_typ-13 Family
IPR005420 Zona occludens protein ZO-3 ZonOcculS3 Family
IPR015724 Serine endopeptidase DegP2 Pept_DepP2 Family
IPR012393 Tricorn protease Tricorn_protease Family
IPR004447 C-terminal-processing peptidase S41A Peptidase_S41A Family
IPR008340 Dishevelled-1 Dishevelled_1 Family
IPR008342 Dishevelled-3 Dishevelled_3 Family
IPR008341 Dishevelled-2 Dishevelled_2 Family
IPR017673 Putative FeS-containing Cyanobacterial-specific oxidoreductase FeS_oxidoreductase_bac Family
IPR011782 Peptidase S1C, Do Pept_S1C_Do Family
IPR011783 Peptidase S1C, DegS Pept_S1C_DegS Family
IPR005419 Zona occludens protein ZO-2 ZonOcculS2 Family
IPR005417 Zona occludens protein ZonOcculdens Family
IPR005418 Zona occludens protein ZO-1 ZonOcculS1 Family
IPR017300 Na(+)/H(+) exchange regulatory cofactor NHE-RF NaH_exchngr_reg_CF_NHE-RF Family
IPR014219 Peptidase S55, sporulation stage IV, protein B Pept_S55_SpoIVB Family
IPR004387 Peptidase M50, putative membrane-associated zinc metallopeptidase Pept_M50_Zn Family
IPR020450 Interleukin-16 IL-16 Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
PDZ domain   GO:0005515 protein binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
PDZ domain   GO:0005515 protein binding

0 Parent Features

1000 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086123 A1ZAN7 Drosophila melanogaster
FBpp0086124 A1ZAN6 Drosophila melanogaster
FBpp0305805 Q9VZY3 Drosophila melanogaster
FBpp0305807 M9PE32 Drosophila melanogaster
FBpp0305804 M9PDV6 Drosophila melanogaster
FBpp0289316 B7Z026 Drosophila melanogaster
FBpp0289315 B7Z025 Drosophila melanogaster
FBpp0078879 Q9VMF3 Drosophila melanogaster
FBpp0302949 G3JX30 Drosophila melanogaster
FBpp0099801 A1ZA47 Drosophila melanogaster
FBpp0302943 G3JX31 Drosophila melanogaster
FBpp0302946 G3JX27 Drosophila melanogaster
FBpp0291373 C1C3E7 Drosophila melanogaster
FBpp0302944 G3JX25 Drosophila melanogaster
FBpp0302950 G3JX32 Drosophila melanogaster
FBpp0302948 G3JX29 Drosophila melanogaster
FBpp0302947 G3JX28 Drosophila melanogaster
FBpp0088159 Q8MR31 Drosophila melanogaster
FBpp0074664 Q9VW57 Drosophila melanogaster
FBpp0070830 Q9W450 Drosophila melanogaster
FBpp0087243 Q961J0 Drosophila melanogaster
FBpp0293662 D3DMF9 Drosophila melanogaster
FBpp0071820 Q24008 Drosophila melanogaster
FBpp0079976 Q8SY07 Drosophila melanogaster
FBpp0079977 Q86PF5 Drosophila melanogaster
FBpp0072664 Q9NB04 Drosophila melanogaster
FBpp0099961 Q9W283 Drosophila melanogaster
FBpp0112308 A8JR81 Drosophila melanogaster
FBpp0112307 A8JR82 Drosophila melanogaster
FBpp0291397 E2QD55 Drosophila melanogaster