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Protein Domain : IPR008984

Name  SMAD/FHA domain Short Name  SMAD_FHA_domain
Type  Domain Description  FHA and SMAD (MH2) domains share a common structure consisting of a sandwich of eleven beta strands in two sheets with Greek key topology. Forkhead-associated (FHA) domains were originally identified as a sequence profile of about 75 amino acids, whereas the full-length domain is closer to about 150 amino acids. FHA domains are found in transcription factors, kinesin motors, and in a variety of other signalling molecules in organisms ranging from eubacteria to humans. FHA domains are protein-protein interaction domains that are specific for phosphoproteins. FHA-containing proteins function in maintaining cell-cycle checkpoints, DNA repair and transcriptional regulation. FHA domain proteins include the Chk2/Rad53/Cds1 family of proteins that contain one or more FHA domains, as well as a Ser/Thr kinase domain [, , ]. SMAD (Mothers against decapentaplegic (MAD) homolog) domain proteins are found in a range of species from nematodes to humans. These highly conserved proteins contain an N-terminal MH1 domain that contacts DNA, and is separated by a short linker region from the C-terminal MH2 domain, the later showing a striking similarity to FHA domains. SMAD proteins mediate signalling by the TGF-beta/activin/BMP-2/4 cytokines from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD proteins fall into three functional classes: the receptor-regulated SMADs (R-SMADs), including SMAD1, -2, -3, -5, and -8, each of which is involved in a ligand-specific signalling pathway []; the comediator SMADs (co-SMADs), including SMAD4, which interact with R-SMADs to participate in signalling []; and the inhibitory SMADs (I-SMADs), including SMAD6 and -7, which block the activation of R-SMADs and Co-SMADs, thereby negatively regulating signalling pathways []. Domains with this fold are also found as the transactivation domain of interferon regulatory factor 3 (IRF3), which has a weak homology to SMAD domains [], and the N-terminal domain of EssC protein in Staphylococcus aureus.

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR017855 SMAD domain-like SMAD_dom-like Domain
IPR000253 Forkhead-associated (FHA) domain FHA_dom Domain

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
SSF49879 SSF IPR008984

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

2 Found In

DB identifier Name Short Name Type
IPR016256 Serine/threonine-protein kinase Rad53 Ser/Thr_kinase_Rad53 Family
IPR012843 Type III secretion system YscD/HrpQ T3SS_YscD/HrpQ Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
SMAD/FHA domain   GO:0005515 protein binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
SMAD/FHA domain   GO:0005515 protein binding

0 Parent Features

306 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0304899 M9PI07 Drosophila melanogaster
FBpp0304900 M9PC64 Drosophila melanogaster
FBpp0304898 M9PF47 Drosophila melanogaster
FBpp0291179 Q0E8F8 Drosophila melanogaster
FBpp0290009 Q8IQE9 Drosophila melanogaster
FBpp0290059 Q9VYP9 Drosophila melanogaster
FBpp0099512 Q5U110 Drosophila melanogaster
FBpp0074160 Q9VX80 Drosophila melanogaster
FBpp0087160 A1Z8Q9 Drosophila melanogaster
FBpp0085176 O62609 Drosophila melanogaster
FBpp0085177 Q8IMG6 Drosophila melanogaster
FBpp0073758 Q8IR47 Drosophila melanogaster
FBpp0084581 Q9VB25 Drosophila melanogaster
FBpp0080864 Q9VIP4 Drosophila melanogaster
FBpp0086206 Q9V7W9 Drosophila melanogaster
FBpp0077302 P42003 Drosophila melanogaster
FBpp0080860 O61267 Drosophila melanogaster
FBpp0080861 A4V0X0 Drosophila melanogaster
FBpp0071140 O96660 Drosophila melanogaster
FBpp0086490 A1ZA18 Drosophila melanogaster
FBpp0087146 A1Z8R0 Drosophila melanogaster
FBpp0087145 A1Z8R1 Drosophila melanogaster
FBpp0086500 Q7K0W0 Drosophila melanogaster
FBpp0086499 A1Z9Z1 Drosophila melanogaster
FBpp0081343 Q9VHS0 Drosophila melanogaster
FBpp0291582 Q9W5R5 Drosophila melanogaster
FBpp0112000 A1ZAJ2 Drosophila melanogaster
FBpp0112453 Q9W5Q1 Drosophila melanogaster
FBpp0297182 Q9VT40 Drosophila melanogaster
FBpp0297181 M9NF67 Drosophila melanogaster