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Protein Domain : IPR017855

Name  SMAD domain-like Short Name  SMAD_dom-like
Type  Domain Description  This entry represents SMAD (Mothers against decapentaplegic (MAD) homolog) (also called MH2 for MAD homology 2) domains as well as their structural homologues, such as the transactivation domain of interferon regulatory protein 3 (IRF3), both of which have a beta-sandwich structural fold.SMAD domains are found at the carboxy terminus of MAD related proteins such as Smads. SMAD (Mothers against decapentaplegic (MAD) homolog) domain proteins are found in a range of species from nematodes to humans. These highly conserved proteins contain an N-terminal MH1 domain that contacts DNA, and is separated by a short linker region from the C-terminal MH2 domain, the later showing a striking similarity to FHA domains. SMAD proteins mediate signalling by the TGF-beta/activin/BMP-2/4 cytokines from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD proteins fall into three functional classes: the receptor-regulated SMADs (R-SMADs), including SMAD1, -2, -3, -5, and -8, each of which is involved in a ligand-specific signalling pathway []; the comediator SMADs (co-SMADs), including SMAD4, which interact with R-SMADs to participate in signalling []; and the inhibitory SMADs (I-SMADs), including SMAD6 and -7, which block the activation of R-SMADs and Co-SMADs, thereby negatively regulating signalling pathways [].

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR001132 SMAD domain, Dwarfin-type SMAD_dom_Dwarfin-type Domain
IPR019471 Interferon regulatory factor-3 Interferon_reg_factor-3 Domain

0 Contains

1 Cross References

Source . Name

Subject . Primary Identifier

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Name Short Name Type
IPR008984 SMAD/FHA domain SMAD_FHA_domain Domain

95 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0099512 Q5U110 Drosophila melanogaster
FBpp0087160 A1Z8Q9 Drosophila melanogaster
FBpp0085176 O62609 Drosophila melanogaster
FBpp0085177 Q8IMG6 Drosophila melanogaster
FBpp0077302 P42003 Drosophila melanogaster
FBpp0071140 O96660 Drosophila melanogaster
FBpp0087146 A1Z8R0 Drosophila melanogaster
FBpp0087145 A1Z8R1 Drosophila melanogaster
FBpp0304648 M9PBX0 Drosophila melanogaster
FBpp0275925 Q28XB3 Drosophila pseudoobscura
FBpp0278627 B5E186 Drosophila pseudoobscura
FBpp0306306 N6VFU1 Drosophila pseudoobscura
FBpp0297040 I5AND6 Drosophila pseudoobscura
FBpp0297039 Q29AF0 Drosophila pseudoobscura
FBpp0282725 Q29HD9 Drosophila pseudoobscura
FBpp0284200 Q297H8 Drosophila pseudoobscura
FBpp0287731 B5DJI3 Drosophila pseudoobscura
FBpp0163632 B4L8H6 Drosophila mojavensis
FBpp0167198 B4KEV0 Drosophila mojavensis
FBpp0168807 B4KSD5 Drosophila mojavensis
FBpp0169175 B4KSD6 Drosophila mojavensis
FBpp0172617 B4K7Y4 Drosophila mojavensis
FBpp0173071 B4KC87 Drosophila mojavensis
FBpp0224986 B4M5J3 Drosophila virilis
FBpp0232326 B4MDX2 Drosophila virilis
FBpp0232786 B4MDX3 Drosophila virilis
FBpp0233179 B4M1Z3 Drosophila virilis
FBpp0233970 B4LU30 Drosophila virilis
FBpp0237509 B4M0Z7 Drosophila virilis
FBpp0255962 B4PNF5 Drosophila yakuba