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Protein Domain : IPR000697

Name  WH1/EVH1 Short Name  WH1/EVH1
Type  Domain Description  The EVH1 (WH1, RanBP1-WASP) domain is found in multi-domain proteins implicated in a diverse range of signalling, nuclear transport and cytoskeletal events. This domain of around 115 amino acids is present in species ranging from yeast to mammals. Many EVH1-containing proteins associate with actin-based structures and play a role in cytoskeletal organisation. EVH1 domains recognise and bind the proline-rich motif FPPPP with low-affinity, further interactions then form between flanking residues [, ].WASP family proteins contain a EVH1 (WH1) in their N-terminals which bind proline-rich sequences in the WASP interacting protein. Proteins of the RanBP1 family contain a WH1 domain in their N-terminal region, which seems to bind a different sequence motif present in the C-terminal part of RanGTP protein [,]. Tertiary structure of the WH1 domain of the Mena protein revealed structure similarities with the pleckstrin homology (PH) domain. The overall fold consists of a compact parallel beta-sandwich, closed along one edge by a long alpha-helix. A highly conserved cluster of three surface-exposed aromatic side-chains forms the recognition site for the molecules target ligands. [].

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Source . Name

Subject . Primary Identifier
PF00568 PFAM IPR000697
PS50229 PROFILE IPR000697
SM00461 SMART IPR000697

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Name Short Name Type
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain

63 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086597 Q7K0G4 Drosophila melanogaster
FBpp0084721 Q9VAT0 Drosophila melanogaster
FBpp0084723 Q86B74 Drosophila melanogaster
FBpp0078936 O96607 Drosophila melanogaster
FBpp0078937 Q9VM94 Drosophila melanogaster
FBpp0302914 F0JAK5 Drosophila melanogaster
FBpp0113115 Q8T4F7 Drosophila melanogaster
FBpp0303158 M9PE98 Drosophila melanogaster
FBpp0303156 M9PHI5 Drosophila melanogaster
FBpp0111624 Q8IQ62 Drosophila melanogaster
FBpp0111620 P91621 Drosophila melanogaster
FBpp0302927 Q0E8S7 Drosophila melanogaster
FBpp0305538 M9PEX1 Drosophila melanogaster
FBpp0304608 M9PB54 Drosophila melanogaster
FBpp0274304 B5DPN2 Drosophila pseudoobscura
FBpp0276778 Q291B4 Drosophila pseudoobscura
FBpp0278946 Q29P19 Drosophila pseudoobscura
FBpp0283278 Q29BJ9 Drosophila pseudoobscura
FBpp0159742 B4K7P9 Drosophila mojavensis
FBpp0161355 B4KV30 Drosophila mojavensis
FBpp0166759 B4KGH6 Drosophila mojavensis
FBpp0167961 B4KNN8 Drosophila mojavensis
FBpp0168131 B4KU69 Drosophila mojavensis
FBpp0227831 B4LBF2 Drosophila virilis
FBpp0229871 B4LR87 Drosophila virilis
FBpp0234186 B4MCP0 Drosophila virilis
FBpp0236183 B4LM72 Drosophila virilis
FBpp0238594 B4M183 Drosophila virilis
FBpp0255502 B4PQP3 Drosophila yakuba
FBpp0257031 B4PBP8 Drosophila yakuba