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Protein Domain : IPR005828

Name  General substrate transporter Short Name  Sub_transporter
Type  Family Description  Recent genome-sequencing data and a wealth of biochemical and molecular genetic investigations have revealed the occurrence of dozens of families of primary and secondary transporters. Two such families have been found to occur ubiquitously in all classifications of living organisms. These are the ATP-binding cassette (ABC) superfamily and the major facilitator superfamily (MFS), also called the uniporter-symporter-antiporter family. While ABC family permeases are in general multicomponent primary active transporters, capable of transporting both small molecules and macromolecules in response to ATP hydrolysis the MFS transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients. Although well over 100 families of transporters have now been recognised and classified, the ABC superfamily and MFS account for nearly half of the solute transporters encoded within the genomes of microorganisms. They are also prevalent in higher organisms. The importance of these two families of transport systems to living organisms can therefore not be overestimated [].The MFS was originally believed to function primarily in the uptake of sugars but subsequent studies revealed that drug efflux systems, Krebs cycle metabolites, organophosphate:phosphate exchangers, oligosaccharide:H1 symport permeases, and bacterial aromatic acid permeases were all members of the MFS. These observations led to the probability that the MFS is far more widespread in nature and far more diverse in function than had been thought previously. 17 subgroups of the MFS have been identified [].Evidence suggests that the MFS permeases arose by a tandem intragenic duplication event in the early prokaryotes. This event generated a 2-transmembrane-spanner (TMS) protein topology from a primordial 6-TMS unit. Surprisingly, all currently recognised MFS permeases retain the two six-TMS units within a single polypeptide chain, although in 3 of the 17 MFS families, an additional two TMSs are found []. Moreover, the well-conserved MFS specific motif between TMS2 and TMS3 and the related but less well conserved motif between TMS8 and TMS9 []prove to be a characteristic of virtually all of the more than 300 MFS proteins identified.

Publication Counts Displayer

4 Child Features

DB identifier Name Short Name Type
IPR003663 Sugar/inositol transporter Sugar/inositol_transpt Family
IPR004749 Organic cation transport protein Orgcat_transp Family
IPR004736 Citrate-proton symport Cit_H_symport Family
IPR004738 Phosphate permease Phos_permease Family

1 Contains

DB identifier Name Short Name Type
IPR005829 Sugar transporter, conserved site Sugar_transporter_CS Conserved_site

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00083 PFAM IPR005828

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
General substrate transporter   GO:0022857 transmembrane transporter activity
General substrate transporter   GO:0055085 transmembrane transport
General substrate transporter   GO:0016021 integral component of membrane

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
General substrate transporter   GO:0022857 transmembrane transporter activity
General substrate transporter   GO:0055085 transmembrane transport
General substrate transporter   GO:0016021 integral component of membrane

0 Parent Features

668 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0112109 A8JQU1 Drosophila melanogaster
FBpp0112108 Q8T0T6 Drosophila melanogaster
FBpp0070973 Q9W3S8 Drosophila melanogaster
FBpp0083982 Q95R48 Drosophila melanogaster
FBpp0072106 Q8SYM5 Drosophila melanogaster
FBpp0083193 Q9VDV7 Drosophila melanogaster
FBpp0077268 Q9VQN6 Drosophila melanogaster
FBpp0086928 Q961J5 Drosophila melanogaster
FBpp0076044 Q9VT79 Drosophila melanogaster
FBpp0083983 Q9VCA2 Drosophila melanogaster
FBpp0072148 Q8MLQ7 Drosophila melanogaster
FBpp0085319 Q0IGX4 Drosophila melanogaster
FBpp0086878 Q95TW6 Drosophila melanogaster
FBpp0082723 Q9VEW7 Drosophila melanogaster
FBpp0070946 Q9W3W9 Drosophila melanogaster
FBpp0082450 Q9VFG2 Drosophila melanogaster
FBpp0076737 Q9VRQ8 Drosophila melanogaster
FBpp0087856 Q9U622 Drosophila melanogaster
FBpp0086060 Q7K3P6 Drosophila melanogaster
FBpp0083194 Q9VDV6 Drosophila melanogaster
FBpp0082730 Q961R9 Drosophila melanogaster
FBpp0081119 Q86BP4 Drosophila melanogaster
FBpp0082790 P53403 Drosophila melanogaster
FBpp0078128 Q9VNW8 Drosophila melanogaster
FBpp0076043 Q8IQE0 Drosophila melanogaster
FBpp0077271 Q9VQN9 Drosophila melanogaster
FBpp0078292 Q7JVN6 Drosophila melanogaster
FBpp0087855 Q7KK97 Drosophila melanogaster
FBpp0082721 Q9VEW9 Drosophila melanogaster
FBpp0082451 Q9VFG1 Drosophila melanogaster