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Protein Domain : IPR016196

Name  Major facilitator superfamily domain, general substrate transporter Short Name  MFS_dom_general_subst_transpt
Type  Domain Description  This entry represents the major facilitator superfamily (MFS) domain, which consists of twelve transmembrane helices. MFS proteins are the largest group of secondary membrane transporters in the cell. Among the different families of transporters, only two occur ubiquitously in all classifications of organisms; these are the ATP-Binding Cassette (ABC) superfamily and the Major Facilitator Superfamily (MFS). The MFS transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients [, ]. The MFS family contains members that function as uniporters, symporters or antiporters. In addition their solute specificity are also diverse. MFS proteins contain 12 transmembrane regions (with some variations). This domain can be found in glycerol-3-phosphate transporter from Escherichia coli, which transports glycerol-3-phosphate into the cytoplasm and inorganic phosphate into the periplasm []. The E. coli proton/sugar transporter lactose permease (LacY) also carries this domain, and acts to couple lactose and H+ translocation [, ].

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR020846 Major facilitator superfamily domain MFS_dom Domain

5 Contains

DB identifier Name Short Name Type
IPR005829 Sugar transporter, conserved site Sugar_transporter_CS Conserved_site
IPR018456 PTR2 family proton/oligopeptide symporter, conserved site PTR2_symporter_CS Conserved_site
IPR021159 Glycerate/sugar phosphate transporter, conserved site Sugar-P_transporter_CS Conserved_site
IPR018457 LacY/RafB permease family, conserved site LacY/RafB_perm_fam_CS Conserved_site
IPR018043 Sodium:galactoside symporter, conserved site Na/Gal_symport_CS Conserved_site

1 Cross References

Source . Name

Subject . Primary Identifier
SSF103473 SSF IPR016196

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

4 Found In

DB identifier Name Short Name Type
IPR005989 Sucrose/H+ symporter, plant Suc_symporter_pln Family
IPR022308 Synaptic vesicle protein SV2 SV2 Family
IPR004742 Sialic acid transporter SA_transporter Family
IPR014090 Siderophore transporter, RhtX/FptX family Siderophore_transpt_RhtX/FptX Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

2120 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0074118 Q9Y115 Drosophila melanogaster
FBpp0076669 Q0E8H7 Drosophila melanogaster
FBpp0077623 Q9VPX2 Drosophila melanogaster
FBpp0112109 A8JQU1 Drosophila melanogaster
FBpp0112108 Q8T0T6 Drosophila melanogaster
FBpp0079426 Q7KTG4 Drosophila melanogaster
FBpp0071802 Q9W1Z3 Drosophila melanogaster
FBpp0083412 Q9V395 Drosophila melanogaster
FBpp0076231 Q9VSV1 Drosophila melanogaster
FBpp0077864 Q9VPE0 Drosophila melanogaster
FBpp0291857 C5WLR3 Drosophila melanogaster
FBpp0086662 Q7K1L4 Drosophila melanogaster
FBpp0078956 Q8SY02 Drosophila melanogaster
FBpp0086347 Q0E960 Drosophila melanogaster
FBpp0070973 Q9W3S8 Drosophila melanogaster
FBpp0083982 Q95R48 Drosophila melanogaster
FBpp0074939 Q9VVH9 Drosophila melanogaster
FBpp0074933 Q9VVL0 Drosophila melanogaster
FBpp0079966 Q9VK84 Drosophila melanogaster
FBpp0070399 Q9W502 Drosophila melanogaster
FBpp0071801 Q8MMD6 Drosophila melanogaster
FBpp0290995 Q494G7 Drosophila melanogaster
FBpp0071690 Q9W269 Drosophila melanogaster
FBpp0079952 Q9VK82 Drosophila melanogaster
FBpp0077449 Q9VQC0 Drosophila melanogaster
FBpp0078124 Q9VNX2 Drosophila melanogaster
FBpp0080090 Q9VJW8 Drosophila melanogaster
FBpp0085816 Q8MRP7 Drosophila melanogaster
FBpp0072106 Q8SYM5 Drosophila melanogaster
FBpp0070178 Q9V3J5 Drosophila melanogaster