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Protein Domain : IPR020846

Name  Major facilitator superfamily domain Short Name  MFS_dom
Type  Domain Description  Transporters can be grouped in two classes, primary and secondary carriers. The primary active transporters drive solute accumulation or extrusion by using ATP hydrolysis, photon absorption, electron flow, substrate decarboxylation or methyl transfer. If charged molecules are unidirectionally pumped as a consequence of the consumption of a primary cellular energy source, electron chemical potential results. This potential can than be used to drive the active transport of additional solutes via secondary carriers.Among the different transporter the two largest families that occur ubiquitously in all classifications of organisms are the ATP-Binding Cassette (ABC) primary transporter superfamily (see ) and the Major Facilitator Superfamily (MFS). The MFS transporters are single-polypeptide secondary carriers capable only of transporting small solutes in response to chemiosmotic ion gradients [, ]. They function as uniporters, symporters or antiporters. In addition their solute specificity are also diverse. MFS proteins contain 12 transmembrane regions (with some variations).The 3D-structure of human GLUT1, an archetype of the major facilitator superfamily has been solved []. Helices 1-5, 8, 10-12 are arranged in a 9-member barrel-like manner, delimiting a hydrophilic central channel. Helix 7 is located in the centre of the channel suggesting a role in regulating transport of solutes through the channel.Some proteins known to belong to the MFS superfamily are listed below:Sugar transporters. The largest family, they can function by uniport, solute-solute antiport or solute-cation symport depending on the system or conditions (see ).Drug:H+ antiporters or multidrug transporters. The extrusion of cytotoxic drugs from multidrug resistant cells by overexpressed multidrug transporter is an important cause of failure of the drug-based treatment of patient with cancers or infections by pathogenic microorganisms.Organophosphate:Pi antiporters (OPA). Small permeases restricted to bacteria.Oligosaccharide:H+ symporters (OHS). Permeases restricted to bacteria.Metabolite:H+ symporters (MHS).Nitrate/nitrite symporter (NNP). This family is present in bacteria, fungi and plants. It catalyzes either nitrate uptake or nitrite efflux.Phosphate:H+ symporters (PHS). It is present only in fungi and plants.Nucleoside:H+ symporters (NHS). Small permeases restricted to Gram-negative bacteria.Oxalate/formate antiporters (OFA). Present in bacteria, archaea and eukaryotes.Sialate:H+ symporters (SHS). Small permeases restricted to Gram-negative bacteria.Monocarboxylate porters (MCP).Anion:cation symporters (ACS).Aromatic acid:H+ symporters (AAHS). They transport a variety of aromatic acids as well as cis,cis-muconate. One member of this family (PCAK) serves as a chemoreceptor allowing the bacteria to swim up concentration gradients of its substrate [].Cyanate permeases (CP). Small bacterial proteins of around 400 residues.Proton-dependent oligopeptide transporters (POT). AAHS and POT are the most divergent MFS families. The profile covers the 12 transmembrane regions.

Publication Counts Displayer

0 Child Features

4 Contains

DB identifier Name Short Name Type
IPR005829 Sugar transporter, conserved site Sugar_transporter_CS Conserved_site
IPR018456 PTR2 family proton/oligopeptide symporter, conserved site PTR2_symporter_CS Conserved_site
IPR021159 Glycerate/sugar phosphate transporter, conserved site Sugar-P_transporter_CS Conserved_site
IPR018457 LacY/RafB permease family, conserved site LacY/RafB_perm_fam_CS Conserved_site

1 Cross References

Source . Name

Subject . Primary Identifier
PS50850 PROFILE IPR020846

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

2 Found In

DB identifier Name Short Name Type
IPR022308 Synaptic vesicle protein SV2 SV2 Family
IPR004742 Sialic acid transporter SA_transporter Family

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Name Short Name Type
IPR016196 Major facilitator superfamily domain, general substrate transporter MFS_dom_general_subst_transpt Domain

1605 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0077623 Q9VPX2 Drosophila melanogaster
FBpp0112109 A8JQU1 Drosophila melanogaster
FBpp0112108 Q8T0T6 Drosophila melanogaster
FBpp0071802 Q9W1Z3 Drosophila melanogaster
FBpp0083412 Q9V395 Drosophila melanogaster
FBpp0077864 Q9VPE0 Drosophila melanogaster
FBpp0291857 C5WLR3 Drosophila melanogaster
FBpp0078956 Q8SY02 Drosophila melanogaster
FBpp0086347 Q0E960 Drosophila melanogaster
FBpp0070973 Q9W3S8 Drosophila melanogaster
FBpp0083982 Q95R48 Drosophila melanogaster
FBpp0071801 Q8MMD6 Drosophila melanogaster
FBpp0290995 Q494G7 Drosophila melanogaster
FBpp0077449 Q9VQC0 Drosophila melanogaster
FBpp0078124 Q9VNX2 Drosophila melanogaster
FBpp0080090 Q9VJW8 Drosophila melanogaster
FBpp0085816 Q8MRP7 Drosophila melanogaster
FBpp0072106 Q8SYM5 Drosophila melanogaster
FBpp0070178 Q9V3J5 Drosophila melanogaster
FBpp0077865 Q9VPD9 Drosophila melanogaster
FBpp0083193 Q9VDV7 Drosophila melanogaster
FBpp0077268 Q9VQN6 Drosophila melanogaster
FBpp0086928 Q961J5 Drosophila melanogaster
FBpp0289988 Q4V4X4 Drosophila melanogaster
FBpp0289989 E1JH66 Drosophila melanogaster
FBpp0083983 Q9VCA2 Drosophila melanogaster
FBpp0072148 Q8MLQ7 Drosophila melanogaster
FBpp0081790 Q9VGX7 Drosophila melanogaster
FBpp0081789 Q8MZF0 Drosophila melanogaster
FBpp0085319 Q0IGX4 Drosophila melanogaster