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Protein Domain : IPR005123

Name  Oxoglutarate/iron-dependent dioxygenase Short Name  Oxoglu/Fe-dep_dioxygenase
Type  Domain Description  Enzymes with the Fe(2+) and 2-oxoglutarate (2OG)-dependent dioxygenase domain typically catalyse the oxidation of an organic substrate using a dioxygen molecule, mostly by using ferrous iron as the active site cofactor and 2OG as a co-substrate which is decarboxylated to succinate and CO2 []. Iron 2OG dioxygenase domain proteins are widespread among eukaryotes and bacteria. In metazoans, prolyl hydroxylases containing the domain act as oxygen sensors and catalyse the hydroxylation of conserved prolyl residues in hypoxia-inducible transcription factor (HIF) alpha [, ]. In plants, Fe(II) 2OG dioxygenase domain enzymes catalyse the formation of plant hormones, such as ethylene, gibberellins, anthocyanidins and pigments such as flavones. In bacteria and fungi Fe(II) 2OG dioxygenase domain enzymes participate in the biosynthesis of antibiotics such as penicillin and cephalosporin. The eukaryotic and bacterial protein AlkB that also shows this structural domain is involved in DNA-repair [, ].The iron 2OG dioxygenase domain has a conserved beta-barrel structure [], which forms a double-stranded beta-helix core fold that forms the predominant class of the cupin superfamily ('cupa' means a small barrel in Latin) []. Two histidines and an aspartate residue catalytically bind a metal ion, in general iron but in some cases another metal, directly involved in catalysis. A conserved arginine or lysine residue further near the C-terminal part acts as the basic residue that interacts with the acidic substrate.

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR006620 Prolyl 4-hydroxylase, alpha subunit Pro_4_hyd_alph Domain

1 Contains

DB identifier Name Short Name Type
IPR002057 Isopenicillin N synthase, conserved site Isopenicillin-N_synth_CS Conserved_site

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF03171 PFAM IPR005123
PF13640 PFAM IPR005123
PS51471 PROFILE IPR005123

3 Data Sets

Name URL
TrEMBL data set http://www.ebi.ac.uk/trembl/
InterPro data set  
InterPro GO Annotation data set  

2 Found In

DB identifier Name Short Name Type
IPR004574 Alkylated DNA repair protein AlkB Alkb Family
IPR002283 Isopenicillin N synthase Isopenicillin-N_synthase Family

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Oxoglutarate/iron-dependent dioxygenase   GO:0016491 oxidoreductase activity
Oxoglutarate/iron-dependent dioxygenase   GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Oxoglutarate/iron-dependent dioxygenase   GO:0055114 oxidation-reduction process

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Oxoglutarate/iron-dependent dioxygenase   GO:0016491 oxidoreductase activity
Oxoglutarate/iron-dependent dioxygenase   GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Oxoglutarate/iron-dependent dioxygenase   GO:0055114 oxidation-reduction process

0 Parent Features

214 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0100020 Q9VKU5 Drosophila melanogaster
FBpp0290184 Q9VA52 Drosophila melanogaster
FBpp0110159 Q0KHY6 Drosophila melanogaster
FBpp0085046 Q8IMI2 Drosophila melanogaster
FBpp0293245 Q9VVQ6 Drosophila melanogaster
FBpp0085033 Q9VA50 Drosophila melanogaster
FBpp0085032 Q8T5S8 Drosophila melanogaster
FBpp0085029 Q961I8 Drosophila melanogaster
FBpp0083680 Q86B82 Drosophila melanogaster
FBpp0071849 Q9W232 Drosophila melanogaster
FBpp0099996 Q8MSK0 Drosophila melanogaster
FBpp0085019 Q9VA60 Drosophila melanogaster
FBpp0085050 Q9VA64 Drosophila melanogaster
FBpp0075918 Q9VTH0 Drosophila melanogaster
FBpp0085047 Q9VA61 Drosophila melanogaster
FBpp0308258 Q9I7H9 Drosophila melanogaster
FBpp0085015 Q9I7H5 Drosophila melanogaster
FBpp0085051 Q9VA65 Drosophila melanogaster
FBpp0292502 Q9VL81 Drosophila melanogaster
FBpp0083682 Q9VCZ2 Drosophila melanogaster
FBpp0089414 Q7KUZ2 Drosophila melanogaster
FBpp0083681 Q86B83 Drosophila melanogaster
FBpp0110158 Q0KHY7 Drosophila melanogaster
FBpp0085017 Q4V443 Drosophila melanogaster
FBpp0085012 Q9VA69 Drosophila melanogaster
FBpp0085048 Q9VA63 Drosophila melanogaster
FBpp0289601 Q9VHU7 Drosophila melanogaster
FBpp0303836 Q9VVQ9 Drosophila melanogaster
FBpp0289328 Q8IQS7 Drosophila melanogaster
FBpp0111465 A8DYR4 Drosophila melanogaster