modENCODE |  Help |  blog

Protein Domain : IPR029021

Name  Protein-tyrosine phosphatase-like Short Name  Prot-tyrosine_phosphatase-like
Type  Domain Description  This entry represents a domain found in some protein-tyrosine phosphatases, including dual specificity phosphatases, myotubularin-like phosphatases [], receptor-type tyrosine-protein phosphatases and non receptor-type tyrosine-protein phosphatases. This domain also shares structure similarity with the lipid phosphatase domain in tensin []and tensin like proteins, such as cyclin G-associated kinase (GAK) []and phoshphoinositide phosphatase PTEN (phosphatase and tensin homologue) []. Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is essential for many cellular functions. Tyrosine-specific protein phosphatases (PTPase; ) catalyse the removal of a phosphate group attached to a tyrosine residue, using a cysteinyl-phosphate enzyme intermediate. These enzymes are key regulatory components in signal transduction pathways (such as the MAP kinase pathway) and cell cycle control, and are important in the control of cell growth, proliferation, differentiation and transformation [, ]. The PTP superfamily can be divided into four subfamilies []:(1) pTyr-specific phosphatases(2) dual specificity phosphatases (dTyr and dSer/dThr)(3) Cdc25 phosphatases (dTyr and/or dThr)(4) LMW (low molecular weight) phosphatasesBased on their cellular localisation, PTPases are also classified as:Receptor-like, which are transmembrane receptors that contain PTPase domains []Non-receptor (intracellular) PTPases []All PTPases carry the highly conserved active site motif C(X)5R (PTP signature motif), employ a common catalytic mechanism, and share a similar core structure made of a central parallel beta-sheet with flanking alpha-helices containing a beta-loop-alpha-loop that encompasses the PTP signature motif []. Functional diversity between PTPases is endowed by regulatory domains and subunits.

Publication Counts Displayer

4 Child Features

DB identifier Name Short Name Type
IPR000387 Protein-tyrosine/Dual specificity phosphatase Tyr/Dual-sp_Pase Domain
IPR000340 Dual specificity phosphatase, catalytic domain Dual-sp_phosphatase_cat-dom Domain
IPR010569 Myotubularin-like phosphatase domain Myotubularin-like_Pase_dom Domain
IPR029023 Tensin phosphatase, lipid phosphatase domain Tensin_lipid_phosphatase_dom Domain

0 Contains

2 Cross References

Source . Name

Subject . Primary Identifier
SSF52799 SSF IPR029021

2 Data Sets

Name URL
TrEMBL data set
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

1045 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0099554 Q9W323 Drosophila melanogaster
FBpp0099555 Q9W324 Drosophila melanogaster
FBpp0099556 Q8IRM7 Drosophila melanogaster
FBpp0099558 Q8IRM6 Drosophila melanogaster
FBpp0099559 Q59E68 Drosophila melanogaster
FBpp0074510 Q9VWF4 Drosophila melanogaster
FBpp0074420 Q9VWN2 Drosophila melanogaster
FBpp0111917 A8JUQ2 Drosophila melanogaster
FBpp0083844 Q86BN8 Drosophila melanogaster
FBpp0304559 M9PAZ4 Drosophila melanogaster
FBpp0290630 Q9VPV8 Drosophila melanogaster
FBpp0290631 Q59E11 Drosophila melanogaster
FBpp0073764 Q9VY15 Drosophila melanogaster
FBpp0086114 Q9NDR1 Drosophila melanogaster
FBpp0071938 Q8MLR7 Drosophila melanogaster
FBpp0071937 Q9W1Q6 Drosophila melanogaster
FBpp0070363 L7XAI0 Drosophila melanogaster
FBpp0080414 O61722 Drosophila melanogaster
FBpp0290828 Q6NN85 Drosophila melanogaster
FBpp0087183 Q8SX38 Drosophila melanogaster
FBpp0082003 Q9VGH9 Drosophila melanogaster
FBpp0082004 Q7KSP6 Drosophila melanogaster
FBpp0072602 Q9W0G1 Drosophila melanogaster
FBpp0072603 Q8IRH4 Drosophila melanogaster
FBpp0080801 P16621 Drosophila melanogaster
FBpp0075565 Q8IQK0 Drosophila melanogaster
FBpp0075564 Q8IQK1 Drosophila melanogaster
FBpp0075562 Q9VU80 Drosophila melanogaster
FBpp0290827 E1JIW2 Drosophila melanogaster
FBpp0074802 Q9VVW5 Drosophila melanogaster