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Protein Domain : IPR000245

Name  V-ATPase proteolipid subunit Short Name  ATPase_proteolipid_csu
Type  Family Description  Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP. There are several different types of transmembrane ATPases, which can differ in function (ATP hydrolysis and/or synthesis), structure (e.g., F-, V- and A-ATPases, which contain rotary motors) and in the type of ions they transport [, ]. The different types include:F-ATPases (F1F0-ATPases), which are found in mitochondria, chloroplasts and bacterial plasma membranes where they are the prime producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).V-ATPases (V1V0-ATPases), which are primarily found in eukaryotic and they function as proton pumps that acidify intracellular compartments and, in some cases, transport protons across the plasma membrane []. They are also found in bacteria [].A-ATPases (A1A0-ATPases), which are found in Archaea and function like F-ATPases, though with respect to their structure and some inhibitor responses, A-ATPases are more closely related to the V-ATPases [, ].P-ATPases (E1E2-ATPases), which are found in bacteria and in eukaryotic plasma membranes and organelles, and function to transport a variety of different ions across membranes.E-ATPases, which are cell-surface enzymes that hydrolyse a range of NTPs, including extracellular ATP.V-ATPases (also known as V1V0-ATPase or vacuolar ATPase) () are found in the eukaryotic endomembrane system, and in the plasma membrane of prokaryotes and certain specialised eukaryotic cells. V-ATPases hydrolyse ATP to drive a proton pump, and are involved in a variety of vital intra- and inter-cellular processes such as receptor mediated endocytosis, protein trafficking, active transport of metabolites, homeostasis and neurotransmitter release []. V-ATPases are composed of two linked complexes: the V1 complex (subunits A-H) contains the catalytic core that hydrolyses ATP, while the V0 complex (subunits a, c, c', c'', d) forms the membrane-spanning pore. V-ATPases may have an additional role in membrane fusion through binding to t-SNARE proteins [].This entry represents the 16 kDa proteolipid subunit c that is part of the V0 complex of V-ATPase in eukaryotic organelles and in certain bacteria. There are three proteolipid subunits (c, c' and c'') that form part of the proton-conducting pore, each containing a buried glutamic acid residue that is essential for proton transport, and together they form a hexameric ring spanning the membrane [, ].

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR011555 V-ATPase proteolipid subunit C, eukaryotic ATPase_proteolipid_su_C_euk Family

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PR00122 PRINTS IPR000245

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
V-ATPase proteolipid subunit   GO:0015078 hydrogen ion transmembrane transporter activity
V-ATPase proteolipid subunit   GO:0015991 ATP hydrolysis coupled proton transport
V-ATPase proteolipid subunit   GO:0033179 proton-transporting V-type ATPase, V0 domain

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
V-ATPase proteolipid subunit   GO:0015078 hydrogen ion transmembrane transporter activity
V-ATPase proteolipid subunit   GO:0015991 ATP hydrolysis coupled proton transport
V-ATPase proteolipid subunit   GO:0033179 proton-transporting V-type ATPase, V0 domain

0 Parent Features

44 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0075822 Q9VTI6 Drosophila melanogaster
FBpp0075821 Q8IQG3 Drosophila melanogaster
FBpp0300391 Q9VFE3 Drosophila melanogaster
FBpp0086218 A1ZAL7 Drosophila melanogaster
FBpp0079709 Q9VKQ8 Drosophila melanogaster
FBpp0085483 P23380 Drosophila melanogaster
FBpp0288461 Q9VFE5 Drosophila melanogaster
FBpp0281587 Q296J4 Drosophila pseudoobscura
FBpp0275818 Q28WX5 Drosophila pseudoobscura
FBpp0276655 Q290J9 Drosophila pseudoobscura
FBpp0279016 B5DHG5 Drosophila pseudoobscura
FBpp0281396 B5DYR7 Drosophila pseudoobscura
FBpp0281398 B5DYR6 Drosophila pseudoobscura
FBpp0281589 B5DXP5 Drosophila pseudoobscura
FBpp0160829 B4L198 Drosophila mojavensis
FBpp0160830 B4L197 Drosophila mojavensis
FBpp0162530 B4KLB1 Drosophila mojavensis
FBpp0170495 B4KUH4 Drosophila mojavensis
FBpp0172211 B4K551 Drosophila mojavensis
FBpp0172213 B4K549 Drosophila mojavensis
FBpp0225708 B4LC71 Drosophila virilis
FBpp0225709 B4LC70 Drosophila virilis
FBpp0226360 B4LRX2 Drosophila virilis
FBpp0235297 B4LIM5 Drosophila virilis
FBpp0239109 B4M0U4 Drosophila virilis
FBpp0239111 B4M0U6 Drosophila virilis
FBpp0258394 B4P0T9 Drosophila yakuba
FBpp0259243 B4P8K1 Drosophila yakuba
FBpp0266822 B4PF44 Drosophila yakuba
FBpp0266823 B4PF45 Drosophila yakuba