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Protein Domain : IPR018200

Name  Peptidase C19, ubiquitin carboxyl-terminal hydrolase, conserved site Short Name  Pept_C19ubi-hydrolase_C_CS
Type  Conserved_site Description  Ubiquitin carboxyl-terminal hydrolases () (UCH) (deubiquitinatingenzymes) []are thiol proteases that recognise and hydrolyze the peptidebond at the C-terminal glycine of ubiquitin. These enzymes are involved in theprocessing of poly-ubiquitin precursors as well as that of ubiquinatedproteins.There are two distinct families of UCH. The second class consist of largeproteins (800 to 2000 residues) and is currently represented by:Yeast UBP1, UBP2, UBP3, UBP4 (or DOA4/SSV7), UBP5, UBP7, UBP9, UBP10,UBP11, UBP12, UBP13, UBP14, UBP15 and UBP16.Human tre-2.Human isopeptidase T.Human isopeptidase T-3.Mammalian Ode-1.Mammalian Unp.Mouse Dub-1.Drosophila fat facets protein (gene faf).Mammalian faf homolog.Drosophila D-Ubp-64E.Caenorhabditis elegans hypothetical protein R10E11.3.Caenorhabditis elegans hypothetical protein K02C4.3.These proteins only share two regions of similarity. The first region containsa conserved cysteine which is probably implicated in the catalytic mechanism.The second region contains two conserved histidines residues, one of which isalso probably implicated in the catalytic mechanism. The deubiquitinsing proteases can be split into 2 size ranges (20-30 kDa, ,and 100-200 kDa) []: this family are the 100-200 kDa peptides which includes the Ubp1 ubiquitin peptidase from yeast. Only one conserved cysteine can be identified, along with two conserved histidines. The spacing between the cysteine and the second histidine is thought to be more representative of the cysteine/histidine spacing of a cysteine protease catalytic dyad [].

Publication Counts Displayer

0 Child Features

0 Contains

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS00972 PROSITE IPR018200
PS00973 PROSITE IPR018200

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

2 Found In

DB identifier Name Short Name Type
IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase Peptidase_C19_UCH Domain
IPR016652 Ubiquitinyl hydrolase Ubiquitinyl_hydrolase Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Peptidase C19, ubiquitin carboxyl-terminal hydrolase, conserved site   GO:0036459 ubiquitinyl hydrolase activity
Peptidase C19, ubiquitin carboxyl-terminal hydrolase, conserved site   GO:0006511 ubiquitin-dependent protein catabolic process

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Peptidase C19, ubiquitin carboxyl-terminal hydrolase, conserved site   GO:0036459 ubiquitinyl hydrolase activity
Peptidase C19, ubiquitin carboxyl-terminal hydrolase, conserved site   GO:0006511 ubiquitin-dependent protein catabolic process

0 Parent Features

243 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0087062 Q7JQI1 Drosophila melanogaster
FBpp0072276 Q9W117 Drosophila melanogaster
FBpp0072976 Q9VZU7 Drosophila melanogaster
FBpp0070793 Q9W462 Drosophila melanogaster
FBpp0076806 Q9VRP5 Drosophila melanogaster
FBpp0305464 M9PDK3 Drosophila melanogaster
FBpp0072486 Q9W0L7 Drosophila melanogaster
FBpp0086664 Q7JW61 Drosophila melanogaster
FBpp0070739 Q9W4C3 Drosophila melanogaster
FBpp0073474 Q9VYQ8 Drosophila melanogaster
FBpp0085202 P55824 Drosophila melanogaster
FBpp0076802 Q24574 Drosophila melanogaster
FBpp0084048 Q9VC56 Drosophila melanogaster
FBpp0084047 Q7KS15 Drosophila melanogaster
FBpp0083419 Q9VDD8 Drosophila melanogaster
FBpp0293257 H1UUC2 Drosophila melanogaster
FBpp0077042 Q8IQ26 Drosophila melanogaster
FBpp0077038 Q9VR54 Drosophila melanogaster
FBpp0077041 Q8IQ27 Drosophila melanogaster
FBpp0079650 Q9VKZ8 Drosophila melanogaster
FBpp0304460 M9PG46 Drosophila melanogaster
FBpp0304461 M9PFZ0 Drosophila melanogaster
FBpp0304458 M9PD06 Drosophila melanogaster
FBpp0304459 M9PFQ1 Drosophila melanogaster
FBpp0290056 Q8I077 Drosophila melanogaster
FBpp0083704 Q9VCT9 Drosophila melanogaster
FBpp0300237 I5ANW7 Drosophila pseudoobscura
FBpp0272607 Q29I81 Drosophila pseudoobscura
FBpp0285136 Q29NI2 Drosophila pseudoobscura
FBpp0275216 Q2LZV0 Drosophila pseudoobscura