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Protein Domain : IPR019954

Name  Ubiquitin conserved site Short Name  Ubiquitin_CS
Type  Conserved_site Description  Ubiquitinylation is an ATP-dependent process that involves the action of at least three enzymes: a ubiquitin-activating enzyme (E1, ), a ubiquitin-conjugating enzyme (E2, ), and a ubiquitin ligase (E3, , ), which work sequentially in a cascade. There are many different E3 ligases, which are responsible for the type of ubiquitin chain formed, the specificity of the target protein, and the regulation of the ubiquitinylation process []. Ubiquitinylation is an important regulatory tool that controls the concentration of key signalling proteins, such as those involved in cell cycle control, as well as removing misfolded, damaged or mutant proteins that could be harmful to the cell. Several ubiquitin-like molecules have been discovered, such as Ufm1 (), SUMO1 (), NEDD8, Rad23 (), Elongin B and Parkin (), the latter being involved in Parkinson's disease [].Ubiquitin is a protein of 76 amino acid residues, found in all eukaryotic cells and whose sequence is extremely well conserved from protozoan to vertebrates. Ubiquitin acts through its post-translational attachment (ubiquitinylation) to other proteins, where these modifications alter the function, location or trafficking of the protein, or targets it for destruction by the 26S proteasome []. The terminal glycine in the C-terminal 4-residue tail of ubiquitin can form an isopeptide bond with a lysine residue in the target protein, or with a lysine in another ubiquitin molecule to form a ubiquitin chain that attaches itself to a target protein. Ubiquitin has seven lysine residues, any one of which can be used to link ubiquitin molecules together, resulting in different structures that alter the target protein in different ways. It appears that Lys(11)-, Lys(29) and Lys(48)-linked poly-ubiquitin chains target the protein to the proteasome for degradation, while mono-ubiquitinylated and Lys(6)- or Lys(63)-linked poly-ubiquitin chains signal reversible modifications in protein activity, location or trafficking []. For example, Lys(63)-linked poly-ubiquitinylation is known to be involved in DNA damage tolerance, inflammatory response, protein trafficking and signal transduction through kinase activation []. In addition, the length of the ubiquitin chain alters the fate of the target protein. Regulatory proteins such as transcription factors and histones are frequent targets of ubquitinylation [].This entry represents the conserved region at the centre of the Ubiquitin sequence.

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0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS00299 PROSITE IPR019954

2 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  

2 Found In

DB identifier Name Short Name Type
IPR000626 Ubiquitin-like Ubiquitin-like Domain
IPR019956 Ubiquitin Ubiquitin Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

65 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0073035 P0CG69 Drosophila melanogaster
FBpp0079606 P15357 Drosophila melanogaster
FBpp0080733 Q9VJ33 Drosophila melanogaster
FBpp0305700 R9PY16 Drosophila melanogaster
FBpp0076505 Q9VS82 Drosophila melanogaster
FBpp0076506 Q9VS83 Drosophila melanogaster
FBpp0077159 P18101 Drosophila melanogaster
FBpp0070894 Q9W418 Drosophila melanogaster
FBpp0288464 B7Z0D4 Drosophila melanogaster
FBpp0288465 B7Z0D3 Drosophila melanogaster
FBpp0293610 M9ND57 Drosophila melanogaster
FBpp0304452 M9PBU3 Drosophila melanogaster
FBpp0304451 M9PHN9 Drosophila melanogaster
FBpp0304453 M9PEE7 Drosophila melanogaster
FBpp0291618 I5AMR3 Drosophila pseudoobscura
FBpp0274900 Q2M125 Drosophila pseudoobscura
FBpp0276130 B5DVA8 Drosophila pseudoobscura
FBpp0280758 Q29LT5 Drosophila pseudoobscura
FBpp0285214 Q29NP1 Drosophila pseudoobscura
FBpp0165699 B4KFP9 Drosophila mojavensis
FBpp0159835 B4KHP5 Drosophila mojavensis
FBpp0161987 B4KXU3 Drosophila mojavensis
FBpp0162085 B4KYS1 Drosophila mojavensis
FBpp0163489 B4LAP3 Drosophila mojavensis
FBpp0166389 B4KJQ0 Drosophila mojavensis
FBpp0170743 B4L5F4 Drosophila mojavensis
FBpp0227427 B4LE57 Drosophila virilis
FBpp0230417 B4MAX6 Drosophila virilis
FBpp0230485 B4MGL9 Drosophila virilis
FBpp0232095 B4LSJ8 Drosophila virilis