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Protein Domain : IPR011603

Name  2-oxoglutarate dehydrogenase, E1 component Short Name  2oxoglutarate_DH_E1
Type  Family Description  2-oxoglutarate dehydrogenase is a key enzyme in the TCA cycle, converting 2-oxoglutarate, coenzyme A and NAD(+) to succinyl-CoA, NADH and carbon dioxide []. This activity of this enzyme is tightly regulated and it is a major determinant of the metabolic flux through the TCA cycle. This enzyme is composed of multiple copies of three different subunits: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) which is often shared with similar enzymes such as pyruvate dehydrogenase []. The E2 component forms a large multimeric core which binds the peripheral E1 and E3 subunits. The substrate is transferred between the active sites of the different subunits by a lipoyl moiety, bound to a lysine residue from the E2 polypeptide.The E1 subunit of 2-oxoglutarate dehydrogenase catalyses the decarboxylation of this compound in a thiamine pyrophosphate-dependent manner, transferring the resultant succinyl group onto the liposyl moiety bound to the E2 subunit. The E1 ortholog from Corynebacterium glutamicum(Brevibacterium flavum) is unusual in having an N-terminal extension that resembles the E2 component of 2-oxoglutarate dehydrogenase enzyme.

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR023784 2-oxoglutarate dehydrogenase, E1 component, bacterial 2oxoglutarate_DH_E1_bac Family

2 Contains

DB identifier Name Short Name Type
IPR001017 Dehydrogenase, E1 component DH_E1 Domain
IPR005475 Transketolase-like, pyrimidine-binding domain Transketolase-like_Pyr-bd Domain

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR23152 PANTHER IPR011603
PIRSF000157 PIRSF IPR011603
TIGR00239 TIGRFAMs IPR011603

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

0 Found In

4 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
2-oxoglutarate dehydrogenase, E1 component   GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity
2-oxoglutarate dehydrogenase, E1 component   GO:0030976 thiamine pyrophosphate binding
2-oxoglutarate dehydrogenase, E1 component   GO:0006099 tricarboxylic acid cycle
2-oxoglutarate dehydrogenase, E1 component   GO:0055114 oxidation-reduction process

4 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
2-oxoglutarate dehydrogenase, E1 component   GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity
2-oxoglutarate dehydrogenase, E1 component   GO:0030976 thiamine pyrophosphate binding
2-oxoglutarate dehydrogenase, E1 component   GO:0006099 tricarboxylic acid cycle
2-oxoglutarate dehydrogenase, E1 component   GO:0055114 oxidation-reduction process

0 Parent Features

34 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0075028 Q9VVC5 Drosophila melanogaster
FBpp0072631 Q95T35 Drosophila melanogaster
FBpp0072633 Q0E8J6 Drosophila melanogaster
FBpp0075027 Q8IQQ0 Drosophila melanogaster
FBpp0085117 Q9VA02 Drosophila melanogaster
FBpp0290113 E1JHW5 Drosophila melanogaster
FBpp0111773 A8JNU6 Drosophila melanogaster
FBpp0293043 I5AMT5 Drosophila pseudoobscura
FBpp0282990 Q29CE4 Drosophila pseudoobscura
FBpp0286887 Q29E02 Drosophila pseudoobscura
FBpp0286941 Q29DU3 Drosophila pseudoobscura
FBpp0161685 B4KYN6 Drosophila mojavensis
FBpp0162486 B4KW84 Drosophila mojavensis
FBpp0171538 B4K6G8 Drosophila mojavensis
FBpp0224925 B4M5V2 Drosophila virilis
FBpp0226456 B4LHN9 Drosophila virilis
FBpp0226787 B4LDV8 Drosophila virilis
FBpp0255932 B4PNA9 Drosophila yakuba
FBpp0264901 B4PK01 Drosophila yakuba
FBpp0266179 B4PDP7 Drosophila yakuba
ODO1_CAEBR Q623T0 Caenorhabditis briggsae
H2WM83_CAEJA H2WM83 Caenorhabditis japonica
H2VW16_CAEJA H2VW16 Caenorhabditis japonica
G0MPA1_CAEBE G0MPA1 Caenorhabditis brenneri
G0PJV3_CAEBE G0PJV3 Caenorhabditis brenneri
G0PJV2_CAEBE G0PJV2 Caenorhabditis brenneri
DHTK1_CAEEL Q23629 Caenorhabditis elegans
ODO1_CAEEL O61199 Caenorhabditis elegans
F5GUD7_CAEEL F5GUD7 Caenorhabditis elegans
U4PC51_CAEEL U4PC51 Caenorhabditis elegans