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Protein Domain : IPR000859

Name  CUB domain Short Name  CUB_dom
Type  Domain Description  The CUB domain (for complement C1r/C1s, Uegf, Bmp1) is a structural motif of approximately 110 residues found almost exclusively in extracellular and plasma membrane-associated proteins, many of which are developmentally regulated [, ]. These proteins are involved in a diverse range of functions, including complement activation, developmental patterning, tissue repair, axon guidance and angiogenesis, cell signalling, fertilisation, haemostasis, inflammation, neurotransmission, receptor-mediated endocytosis, and tumour suppression []. Many CUB-containing proteins are peptidases belonging to MEROPS peptidase families M12A (astacin) and S1A (chymotrypsin). Proteins containing a CUB domain include:Mammalian complement subcomponents C1s/C1r, which form the calcium-dependent complex C1, the first component of the classical pathway of the complement system.Cricetidae sp.(Hamster) serine protease Casp, which degrades type I and IV collagen and fibronectin in the presence of calcium.Mammalian complement-activating component of Ra-reactive factor (RARF), a protease that cleaves the C4 component of complement.Vertebrate enteropeptidase (), a type II membrane protein of the intestinal brush border, which activates trypsinogen.Vertebrate bone morphogenic protein 1 (BMP-1), a protein which induces cartilage and bone formation and expresses metalloendopeptidase activity.Sea urchin blastula proteins BP10 and SpAN.Caenorhabditis eleganshypothetical proteins F42A10.8 and R151.5.Neuropilin (A5 antigen), a calcium-independent cell adhesion molecule that functions during the formation of certain neuronal circuits.Fibropellins I and III from Strongylocentrotus purpuratus(Purple sea urchin).Mammalian hyaluronate-binding protein TSG-6 (or PS4), a serum and growth factor induced protein.Mammalian spermadhesins.Xenopus laevisembryonic protein UVS.2, which is expressed during dorsoanterior development.Several of the above proteins consist of a catalytic domain together with several CUB domains interspersed by calcium-binding EGF domains. Some CUB domains appear to be involved in oligomerisation and/or recognition of substrates and binding partners. For example, in the complement proteases, the CUB domains mediate dimerisation and binding to collagen-like regions of target proteins (e.g. C1q for C1r/C1s). The structure of CUB domains consists of a beta-sandwich with a jelly-roll fold. Almost all CUB domains contain four conserved cysteines that probably form two disulphide bridges (C1-C2, C3-C4). The CUB1 domains of C1s and Map19 have calcium-binding sites [].

Publication Counts Displayer

0 Child Features

0 Contains

5 Cross References

Source . Name

Subject . Primary Identifier
PF00431 PFAM IPR000859
PS01180 PROFILE IPR000859
SM00042 SMART IPR000859
SSF49854 SSF IPR000859

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

11 Found In

DB identifier Name Short Name Type
IPR017050 Peptidase M12A, astacin, nematode Peptidase_M12A_nem Family
IPR016857 Uncharacterised conserved protein UCP027682, CUB, vWA UCP027682_CUB_vWA Family
IPR015446 Bone morphogenetic protein 1/tolloid-like protein BMP_1/tolloid-like Family
IPR011163 Peptidase S1A, enteropeptidase Pept_S1A_enterop Family
IPR014648 Neuropilin Neuropilin Family
IPR017118 Peptidase S1A, matriptase-2 Pept_S1A_matriptase-2 Family
IPR017076 Kremen Kremen Family
IPR017051 Peptidase S1A, matripase Peptidase_S1A_matripase Family
IPR017369 SPAN protein/blastula protease 10 SPAN/blastula_protease_10 Family
IPR017370 Hatching enzyme, Uvs2 Hatching_enzyme_Uvs2 Family
IPR000124 Spermadhesin Spermadhesin Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

582 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0083152 Q9VDY3 Drosophila melanogaster
FBpp0288558 Q9VM55 Drosophila melanogaster
FBpp0291372 E1JHA6 Drosophila melanogaster
FBpp0112077 Q5BIG2 Drosophila melanogaster
FBpp0077332 Q9VQK3 Drosophila melanogaster
FBpp0076399 Q8IQA8 Drosophila melanogaster
FBpp0076398 Q9VSI3 Drosophila melanogaster
FBpp0076397 Q8IQA9 Drosophila melanogaster
FBpp0076317 Q9VSQ2 Drosophila melanogaster
FBpp0087874 A1Z7D2 Drosophila melanogaster
FBpp0077185 Q9VQV1 Drosophila melanogaster
FBpp0084069 Q9VC47 Drosophila melanogaster
FBpp0080598 Q9VJA6 Drosophila melanogaster
FBpp0087875 A1Z7D1 Drosophila melanogaster
FBpp0087871 A1Z7C5 Drosophila melanogaster
FBpp0308759 Q9VYC7 Drosophila melanogaster
FBpp0308760 G4LU05 Drosophila melanogaster
FBpp0086866 A1Z9B9 Drosophila melanogaster
FBpp0076239 Q9VSR6 Drosophila melanogaster
FBpp0086867 A1Z9B8 Drosophila melanogaster
FBpp0077926 Q9VPA1 Drosophila melanogaster
FBpp0084070 P25723 Drosophila melanogaster
FBpp0271945 Q9W332 Drosophila melanogaster
FBpp0303609 R9PY60 Drosophila melanogaster
FBpp0288819 A8DYL2 Drosophila melanogaster
FBpp0074617 Q9VWA7 Drosophila melanogaster
FBpp0310758 Q15KK8 Drosophila melanogaster
FBpp0111566 A8JQY3 Drosophila melanogaster
FBpp0111568 Q4V495 Drosophila melanogaster
FBpp0290374 Q9VLX5 Drosophila melanogaster