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Protein Domain : IPR011598

Name  Myc-type, basic helix-loop-helix (bHLH) domain Short Name  bHLH_dom
Type  Domain Description  A number of eukaryotic proteins, which probably are sequence specific DNA-binding proteins that act as transcription factors, share a conserved domainof 40 to 50 amino acid residues. It has been proposed []that this domain isformed of two amphipathic helices joined by a variable length linker regionthat could form a loop. This 'helix-loop-helix' (HLH) domain mediates proteindimerization and has been found in the proteins listed below []. Mostof these proteins have an extra basic region of about 15 amino acid residuesthat is adjacent to the HLH domain and specifically binds to DNA. They arerefered as basic helix-loop-helix proteins (bHLH), and are classified in twogroups: class A (ubiquitous) and class B (tissue-specific). Members of thebHLH family bind variations on the core sequence 'CANNTG', also refered to asthe E-box motif. The homo- or heterodimerization mediated by the HLH domain isindependent of, but necessary for DNA binding, as two basic regions arerequired for DNA binding activity. The HLH proteins lacking the basic domain(Emc, Id) function as negative regulators, since they form heterodimers, butfail to bind DNA. The hairy-related proteins (hairy, E(spl), deadpan) alsorepress transcription although they can bind DNA. The proteins of thissubfamily act together with co-repressor proteins, like groucho, through theirC-terminal motif WRPW.Proteins containing a HLH domain include:The myc family of cellular oncogenes [], which is currently known to contain four members: c-myc, N-myc, L-myc, and B-myc. The myc genes are thought to play a role in cellular differentiation and proliferation.Proteins involved in myogenesis (the induction of muscle cells). In mammals MyoD1 (Myf-3), myogenin (Myf-4), Myf-5, and Myf-6 (Mrf4 or herculin), in birds CMD1 (QMF-1), in Xenopus MyoD and MF25, in Caenorhabditis elegans CeMyoD, and in Drosophila nautilus (nau).Vertebrate proteins that bind specific DNA sequences ('E boxes') in various immunoglobulin chains enhancers: E2A or ITF-1 (E12/pan-2 and E47/pan-1), ITF-2 (tcf4), TFE3, and TFEB.Vertebrate neurogenic differentiation factor 1 that acts as differentiation factor during neurogenesis.Vertebrate MAX protein, a transcription regulator that forms a sequence- specific DNA-binding protein complex with myc or mad.Vertebrate Max Interacting Protein 1 (MXI1 protein) which acts as a transcriptional repressor and may antagonize myc transcriptional activity by competing for max.Proteins of the bHLH/PAS superfamily which are transcriptional activators. In mammals, AH receptor nuclear translocator (ARNT), single-minded homologues (SIM1 and SIM2), hypoxia-inducible factor 1 alpha (HIF1A), AH receptor (AHR), neuronal pas domain proteins (NPAS1 and NPAS2), endothelial pas domain protein 1 (EPAS1), mouse ARNT2, and human BMAL1. In Drosophila, single-minded (SIM), AH receptor nuclear translocator (ARNT), trachealess protein (TRH), and similar protein (SIMA).Mammalian transcription factors HES, which repress transcription by acting on two types of DNA sequences, the E box and the N box.Mammalian MAD protein (max dimerizer) which acts as transcriptional repressor and may antagonize myc transcriptional activity by competing for max.Mammalian Upstream Stimulatory Factor 1 and 2 (USF1 and USF2), which bind to a symmetrical DNA sequence that is found in a variety of viral and cellular promoters.Human lyl-1 protein; which is involved, by chromosomal translocation, in T- cell leukemia.Human transcription factor AP-4.Mouse helix-loop-helix proteins MATH-1 and MATH-2 which activate E box- dependent transcription in collaboration with E47.Mammalian stem cell protein (SCL) (also known as tal1), a protein which may play an important role in hemopoietic differentiation. SCL is involved, by chromosomal translocation, in stem-cell leukemia.Mammalian proteins Id1 to Id4 []. Id (inhibitor of DNA binding) proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting binding to DNA.Drosophila extra-macrochaetae (emc) protein, which participates in sensory organ patterning by antagonizing the neurogenic activity of theachaete- scute complex. Emc is the homologue of mammalian Id proteins.Human Sterol Regulatory Element Binding Protein 1 (SREBP-1), a transcriptional activator that binds to the sterol regulatory element 1 (SRE-1) found in the flanking region of the LDLR gene and in other genes.Drosophila achaete-scute (AS-C) complex proteins T3 (l'sc), T4 (scute), T5 (achaete) and T8 (asense). The AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.Mammalian homologues of achaete-scute proteins, the MASH-1 and MASH-2 proteins.Drosophila atonal protein (ato) which is involved in neurogenesis.

Publication Counts Displayer

0 Child Features

0 Contains

5 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00010 PFAM IPR011598
PS50888 PROFILE IPR011598
SM00353 SMART IPR011598
G3DSA:4.10.280.10 GENE3D IPR011598
SSF47459 SSF IPR011598

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

6 Found In

DB identifier Name Short Name Type
IPR015660 Achaete-scute transcription factor-related ASH Family
IPR002418 Transcription regulator Myc Tscrpt_reg_Myc Family
IPR001067 Nuclear translocator Nuc_translocat Family
IPR015789 Twist-related Twist_related Family
IPR017426 Nuclear receptor coactivator Nuclear_rcpt_coactivator Family
IPR016637 Transcription factor, basic helix-loop-helix, NeuroD TF_bHLH_NeuroD Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Myc-type, basic helix-loop-helix (bHLH) domain   GO:0046983 protein dimerization activity

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Myc-type, basic helix-loop-helix (bHLH) domain   GO:0046983 protein dimerization activity

0 Parent Features

653 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0070659 Q9W4I4 Drosophila melanogaster
FBpp0303590 M9PH26 Drosophila melanogaster
FBpp0290660 Q4V6U8 Drosophila melanogaster
FBpp0081723 Q9VGZ5 Drosophila melanogaster
FBpp0084352 P13096 Drosophila melanogaster
FBpp0084334 P13097 Drosophila melanogaster
FBpp0084355 Q01069 Drosophila melanogaster
FBpp0084329 Q01070 Drosophila melanogaster
FBpp0084328 Q01071 Drosophila melanogaster
FBpp0084335 P13098 Drosophila melanogaster
FBpp0099476 P10627 Drosophila melanogaster
FBpp0081042 B6VQA1 Drosophila melanogaster
FBpp0099478 O61735 Drosophila melanogaster
FBpp0099504 P14003 Drosophila melanogaster
FBpp0090974 Q59E67 Drosophila melanogaster
FBpp0084381 P41894 Drosophila melanogaster
FBpp0084332 Q01068 Drosophila melanogaster
FBpp0081483 O15945 Drosophila melanogaster
FBpp0080685 Q9VJ16 Drosophila melanogaster
FBpp0070501 Q9W4S7 Drosophila melanogaster
FBpp0081318 P48987 Drosophila melanogaster
FBpp0074785 P91664 Drosophila melanogaster
FBpp0070669 Q9W4J8 Drosophila melanogaster
FBpp0070074 P09775 Drosophila melanogaster
FBpp0087945 Q7KM13 Drosophila melanogaster
FBpp0088516 Q0IGU7 Drosophila melanogaster
FBpp0081462 Q9VHG3 Drosophila melanogaster
FBpp0070071 P10083 Drosophila melanogaster
FBpp0074642 Q9VW37 Drosophila melanogaster
FBpp0070072 P10084 Drosophila melanogaster