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Protein Domain : IPR007901

Name  MoeZ/MoeB Short Name  MoeZ_MoeB
Type  Domain Description  This putative domain is found in the MoeZ protein and the MoeB protein. The domain has twoCXXC motifs that are only partly conserved. MoeZ is necessary for the synthesis of pyridine-2,6-bis(thiocarboxylic acid), a small secreted metabolite that has a high affinity for transitionmetals, increases iron uptake efficiency by 20% in Pseudomonas stutzeri, has the ability to reduce both soluble and mineral forms ofiron, and has antimicrobial activity towards several species of bacteria. MoeB is the molybdopterin synthase activating enzyme in the molybdopterin cofactor biosynthesis pathway.Both these enzymes are members of a superfamily consisting of related but structurally distinct proteins that are members of pathways involved in thetransfer of sulphur-containing moieties to metabolites []and both also contain the UBA/THIF-type NAD/FAD binding fold ().

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF05237 PFAM IPR007901

2 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  

3 Found In

DB identifier Name Short Name Type
IPR009036 Molybdenum cofactor biosynthesis, MoeB Molybdenum_cofac_synth_MoeB Domain
IPR012731 Thiazole biosynthesis adenylyltransferase ThiF Adenyl_ThiF Family
IPR012730 Molybdopterin synthase sulfurylase MoeB Mopterin_Synthase_Sase_MoeB Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

14 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0079295 Q9VLJ8 Drosophila melanogaster
FBpp0278357 B5DS72 Drosophila pseudoobscura
FBpp0279121 Q29PG5 Drosophila pseudoobscura
FBpp0159670 B4KI53 Drosophila mojavensis
FBpp0236087 B4LRB9 Drosophila virilis
FBpp0263793 B4NXF7 Drosophila yakuba
MOCS3_CAEBR A8WRE3 Caenorhabditis briggsae
H2VHJ1_CAEJA H2VHJ1 Caenorhabditis japonica
G0PBC3_CAEBE G0PBC3 Caenorhabditis brenneri
G0P4R6_CAEBE G0P4R6 Caenorhabditis brenneri
MOCS3_CAEEL O44510 Caenorhabditis elegans
E3NS86_CAERE E3NS86 Caenorhabditis remanei
E3M6N2_CAERE E3M6N2 Caenorhabditis remanei
E3NX04_CAERE E3NX04 Caenorhabditis remanei