modENCODE |  Help |  blog

Protein Domain : IPR028885

Name  Adenylyltransferase and sulfurtransferase MOCS3/Uba4 Short Name  MOCS3/Uba4
Type  Family Description  This entry includes adenylyltransferase and sulfurtransferase MOCS3 and its homologue, Uba4, from yeasts.In budding yeasts, Uba4 receives sulphur from Nfs1 and Tum1 []. Uba4 then forms an acyl adenylate intermediate with the C-terminal of the Urm1 protein, and then forms an acyl disulfide bond between Uba4 Cys397 and the Urm1 C-terminal glycin []. Subsequently, the activated Urm1 acts as a sulphur carrier in the process of eukaryotic transfer RNA (tRNA) thiolation []. MOCS3 plays a central role in 2-thiolation of mcm5S2U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) []. It is also essential during biosynthesis of the molybdenum cofactor [, ]. MOCS3 acts by mediating the C-terminal thiocarboxylation of sulfur carriers Urm1 and MOCS2A (the small subunit of molybdopterin synthase) [, , , ].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
MF_03049 HAMAP IPR028885

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Adenylyltransferase and sulfurtransferase MOCS3/Uba4   GO:0004792 thiosulfate sulfurtransferase activity
Adenylyltransferase and sulfurtransferase MOCS3/Uba4   GO:0002143 tRNA wobble position uridine thiolation
Adenylyltransferase and sulfurtransferase MOCS3/Uba4   GO:0005829 cytosol

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Adenylyltransferase and sulfurtransferase MOCS3/Uba4   GO:0004792 thiosulfate sulfurtransferase activity
Adenylyltransferase and sulfurtransferase MOCS3/Uba4   GO:0002143 tRNA wobble position uridine thiolation
Adenylyltransferase and sulfurtransferase MOCS3/Uba4   GO:0005829 cytosol

0 Parent Features

13 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0079295 Q9VLJ8 Drosophila melanogaster
FBpp0278357 B5DS72 Drosophila pseudoobscura
FBpp0279121 Q29PG5 Drosophila pseudoobscura
FBpp0159670 B4KI53 Drosophila mojavensis
FBpp0236087 B4LRB9 Drosophila virilis
FBpp0263793 B4NXF7 Drosophila yakuba
MOCS3_CAEBR A8WRE3 Caenorhabditis briggsae
H2VHJ1_CAEJA H2VHJ1 Caenorhabditis japonica
G0PBC3_CAEBE G0PBC3 Caenorhabditis brenneri
G0P4R6_CAEBE G0P4R6 Caenorhabditis brenneri
MOCS3_CAEEL O44510 Caenorhabditis elegans
E3NS86_CAERE E3NS86 Caenorhabditis remanei
E3M6N2_CAERE E3M6N2 Caenorhabditis remanei