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Protein Domain : IPR017892

Name  Protein kinase, C-terminal Short Name  Pkinase_C
Type  Domain Description  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].This domain is found in a large variety of protein kinases with different functions and dependencies. Protein kinase C, for example, is a calcium-activated, phospholipid-dependent serine- and threonine-specific enzyme. It is activated by diacylglycerol which, in turn, phosphorylates a range of cellular proteins. This domain is most often found associated with .

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00433 PFAM IPR017892

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

7 Found In

DB identifier Name Short Name Type
IPR012233 Protein kinase C, zeta/iota PKC_zeta Family
IPR016238 Ribosomal protein S6 kinase Ribosomal_S6_kinase Family
IPR016239 Ribosomal protein S6 kinase II Ribosomal_S6_kinase_II Family
IPR014376 Protein kinase C, delta/epsilon/eta/theta types Prot_kin_PKC_delta Family
IPR014375 Protein kinase C, alpha/beta/gamma types Protein_kinase_C_a/b/g Family
IPR020684 Rho-associated protein kinase Rho-assoc_coiled-coil_kin Family
IPR017405 Citron Rho-interacting kinase Citron_Rho-interacting_kinase Family

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Protein kinase, C-terminal   GO:0004674 protein serine/threonine kinase activity
Protein kinase, C-terminal   GO:0005524 ATP binding
Protein kinase, C-terminal   GO:0006468 protein phosphorylation

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Protein kinase, C-terminal   GO:0004674 protein serine/threonine kinase activity
Protein kinase, C-terminal   GO:0005524 ATP binding
Protein kinase, C-terminal   GO:0006468 protein phosphorylation

1 Parent Features

DB identifier Name Short Name Type
IPR000961 AGC-kinase, C-terminal AGC-kinase_C Domain

171 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0076820 Q94533 Drosophila melanogaster
FBpp0290731 Q4QQA3 Drosophila melanogaster
FBpp0075702 Q9VTY8 Drosophila melanogaster
FBpp0087682 A1Z7T0 Drosophila melanogaster
FBpp0087683 A1Z7T1 Drosophila melanogaster
FBpp0087686 A1Z7T4 Drosophila melanogaster
FBpp0087684 A1Z7T2 Drosophila melanogaster
FBpp0082682 Q8INB9 Drosophila melanogaster
FBpp0086196 P13677 Drosophila melanogaster
FBpp0111731 A8DYG9 Drosophila melanogaster
FBpp0293606 D3DMK5 Drosophila melanogaster
FBpp0086197 P05130 Drosophila melanogaster
FBpp0077052 Q9VR61 Drosophila melanogaster
FBpp0292487 A1Z9X0 Drosophila melanogaster
FBpp0075965 Q9V3I5 Drosophila melanogaster
FBpp0292490 Q0E971 Drosophila melanogaster
FBpp0292486 Q0E972 Drosophila melanogaster
FBpp0292488 Q0E974 Drosophila melanogaster
FBpp0292489 Q0E973 Drosophila melanogaster
FBpp0289213 P83099 Drosophila melanogaster
FBpp0309085 Q9VYN1 Drosophila melanogaster
FBpp0087685 A1Z7T3 Drosophila melanogaster
FBpp0111810 A8DY76 Drosophila melanogaster
FBpp0290726 E1JH15 Drosophila melanogaster
FBpp0304889 M9PI41 Drosophila melanogaster
FBpp0288109 B5DVD6 Drosophila pseudoobscura
FBpp0308170 N6V814 Drosophila pseudoobscura
FBpp0308168 B5E1E4 Drosophila pseudoobscura
FBpp0308169 N6VEW0 Drosophila pseudoobscura
FBpp0277776 Q290K1 Drosophila pseudoobscura