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Protein Domain : IPR011011

Name  Zinc finger, FYVE/PHD-type Short Name  Znf_FYVE_PHD
Type  Domain Description  Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis(African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. The FYVE zinc finger domain is conserved from yeast to man, and is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is found mainly on endosomes [, ].The plant homeodomain (PHD) zinc finger domain has a C4HC3-type motif, and is widely distributed in eukaryotes, being found in many chromatin regulatory factors [].Both the FYVE and the PHD zinc finger motifs display strikingly similar dimetal(zinc)-bound alpha+beta folds.

Publication Counts Displayer

3 Child Features

DB identifier Name Short Name Type
IPR001965 Zinc finger, PHD-type Znf_PHD Domain
IPR000306 FYVE zinc finger Znf_FYVE Domain
IPR010911 Zinc finger, FYVE-type Znf_FYVE-typ Domain

4 Contains

DB identifier Name Short Name Type
IPR019787 Zinc finger, PHD-finger Znf_PHD-finger Domain
IPR017455 Zinc finger, FYVE-related Znf_FYVE-rel Domain
IPR019786 Zinc finger, PHD-type, conserved site Zinc_finger_PHD-type_CS Conserved_site
IPR008899 Zinc finger, piccolo-type Znf_piccolo Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
SSF57903 SSF IPR011011

2 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Name Short Name Type
IPR013083 Zinc finger, RING/FYVE/PHD-type Znf_RING/FYVE/PHD Domain

795 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0305727 Q9W5W9 Drosophila melanogaster
FBpp0078775 Q9VML2 Drosophila melanogaster
FBpp0081130 Q7KSZ0 Drosophila melanogaster
FBpp0082409 P20659 Drosophila melanogaster
FBpp0305805 Q9VZY3 Drosophila melanogaster
FBpp0305807 M9PE32 Drosophila melanogaster
FBpp0305804 M9PDV6 Drosophila melanogaster
FBpp0074688 O97159 Drosophila melanogaster
FBpp0304462 M9PIA6 Drosophila melanogaster
FBpp0099808 Q59E34 Drosophila melanogaster
FBpp0072702 Q9W0C3 Drosophila melanogaster
FBpp0088523 O96838 Drosophila melanogaster
FBpp0071262 Q9W352 Drosophila melanogaster
FBpp0292089 M9MS35 Drosophila melanogaster
FBpp0075510 Q9VUB5 Drosophila melanogaster
FBpp0074385 Q9VWS0 Drosophila melanogaster
FBpp0081129 Q9VI63 Drosophila melanogaster
FBpp0074531 Q9VWF2 Drosophila melanogaster
FBpp0082081 Q9VGA4 Drosophila melanogaster
FBpp0072431 Q7YZH1 Drosophila melanogaster
FBpp0071431 Q9W2R9 Drosophila melanogaster
FBpp0072159 Q9W1A9 Drosophila melanogaster
FBpp0071563 Q9W2M0 Drosophila melanogaster
FBpp0088690 C9QP23 Drosophila melanogaster
FBpp0088691 Q960X8 Drosophila melanogaster
FBpp0301130 D4G7E9 Drosophila melanogaster
FBpp0080532 Q9VJE3 Drosophila melanogaster
FBpp0088092 Q7JVP4 Drosophila melanogaster
FBpp0072421 Q9W0T1 Drosophila melanogaster
FBpp0082953 Q9VEF5 Drosophila melanogaster