modENCODE |  Help |  blog

Protein Domain : IPR018979

Name  FERM, N-terminal Short Name  FERM_N
Type  Domain Description  This domain is the N-terminal ubiquitin-like structural domain of the FERM domain. The FERM domain (F for 4.1 protein, E for ezrin, R for radixin and M for moesin) is a widespread protein module involved in localising proteins to the plasma membrane []. FERM domains are found in a number of cytoskeletal-associated proteins that associate with various proteins at the interface between the plasma membrane and the cytoskeleton. The FERM domain is located at the N terminus of the majority of FERM-containing proteins [, ], which includes: Band 4.1, which links the spectrin-actin cytoskeleton of erythrocytes to the plasma membrane.Ezrin, a component of the undercoat of the microvilli plasma membrane.Moesin, which is probably involved in binding major cytoskeletal structures to the plasma membrane.Radixin, which is involved in the binding of the barbed end of actin filaments to the plasma membrane in the undercoat of the cell- to-cell adherens junction.Talin, a cytoskeletal protein concentrated in regions of cell-substratum contact and, in lymphocytes, of cell-cell contacts.Filopodin, a slime mold protein that binds actin and which is involved in the control of cell motility and chemotaxis.Merlin (or schwannomin).Protein NBL4.Unconventional myosins X, VIIa and XV, which are mutated in congenital deafness.Focal-adhesion kinases (FAKs), cytoplasmic protein tyrosine kinases involved in signalling through integrins.Janus tyrosine kinases (JAKs), cytoplasmic tyrosine kinases that are non-covalently associated with the cytoplasmic tails of receptors for cytokines or polypeptidic hormones.Non-receptor tyrosine-protein kinase TYK2.Protein-tyrosine phosphatases PTPN3 and PTPN4, enzyme that appear to act at junctions between the membrane and the cytoskeleton.Protein-tyrosine phosphatases PTPN14 and PTP-D1, PTP-RL10 and PTP2E.Caenorhabditis elegansprotein phosphatase ptp-1.Ezrin, moesin, and radixin are highly related proteins (ERM protein family), but the other proteins in which the FERM domain is found do not share any region of similarity outside of this domain. ERM proteins are made of three domains, the FERM domain, a central helical domain and a C-terminal tail domain, which binds F-actin. The amino-acid sequence of the FERM domain is highly conserved among ERM proteins and is responsible for membrane association by direct binding to the cytoplasmic domain or tail of integral membrane proteins. ERM proteins are regulated by an intramolecular association of the FERM and C-terminal tail domains that masks their binding sites for other molecules. For cytoskeleton-membrane cross-linking, the dormant molecules becomes activated and the FERM domain attaches to the membrane by binding specific membrane proteins, while the last 34 residues of the tail bind actin filaments. Aside from binding to membranes, the activated FERM domain of ERM proteins can also bind the guanine nucleotide dissociation inhibitor of Rho GTPase (RhoDGI), which suggests that in addition to functioning as a cross-linker, ERM proteins may influence Rho signalling pathways. The crystal structure of the FERM domain reveals that it is composed of three structural modules (F1,F2, and F3) that together form a compact clover-shaped structure [].The FERM domain has also been called the amino-terminal domain, the 30kDa domain, 4.1N30, the membrane-cytoskeletal-linking domain, the ERM-like domain, the ezrin-like domain of the band 4.1 superfamily, the conserved N-terminal region, and the membrane attachment domain [].

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier Name Short Name Type
IPR019747 FERM conserved site FERM_CS Conserved_site

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF09379 PFAM IPR018979

2 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  

11 Found In

DB identifier Name Short Name Type
IPR019749 Band 4.1 domain Band_41_domain Domain
IPR000299 FERM domain FERM_domain Domain
IPR019750 Band 4.1 family Band_41_fam Family
IPR012151 Protein-tyrosine phosphatase, non-receptor type-3, -4 Tyr_Pase_non-rcpt_typ-3/4 Family
IPR011174 Ezrin/radixin/moesin ERM Family
IPR000798 Ezrin/radixin/moesin like Ez/rad/moesin_like Family
IPR021187 Band 4.1 protein Band_41_protein Family
IPR014392 Protein-tyrosine phosphatase, non-receptor type-14, -21 Tyr_Pase_non-rcpt_typ-14/21 Family
IPR012153 Protein-tyrosine phosphatase, non-receptor type-13 Tyr_Pase_non-rcpt_typ-13 Family
IPR015710 Talin-1 Talin-1 Family
IPR015711 Talin-2 Talin-2 Family

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Name Short Name Type
IPR029071 Ubiquitin-related domain Ubiquitin-rel_dom Domain

215 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0082261 Q9VFU8 Drosophila melanogaster
FBpp0079099 Q9VLZ3 Drosophila melanogaster
FBpp0079097 Q8IPH8 Drosophila melanogaster
FBpp0080282 Q9V3Z6 Drosophila melanogaster
FBpp0089236 P46150 Drosophila melanogaster
FBpp0078914 Q9V3V3 Drosophila melanogaster
FBpp0074523 Q24564 Drosophila melanogaster
FBpp0079589 Q9VKY7 Drosophila melanogaster
FBpp0085697 Q9V8R9 Drosophila melanogaster
FBpp0290494 H5V8A7 Drosophila melanogaster
FBpp0303991 M9PHG2 Drosophila melanogaster
FBpp0300513 C7LAH9 Drosophila melanogaster
FBpp0071748 Q8SWW8 Drosophila melanogaster
FBpp0288485 A8JPC8 Drosophila melanogaster
FBpp0112924 A0T1Z5 Drosophila melanogaster
FBpp0112923 A0T1Z4 Drosophila melanogaster
FBpp0112925 B7Z0J2 Drosophila melanogaster
FBpp0307779 Q9VN68 Drosophila melanogaster
FBpp0307778 Q2M1E6 Drosophila melanogaster
FBpp0297515 Q9W0R3 Drosophila melanogaster
FBpp0293740 Q9VSL8 Drosophila melanogaster
FBpp0293741 M9NDM3 Drosophila melanogaster
FBpp0305319 M9PBW9 Drosophila melanogaster
FBpp0305320 M9PEJ8 Drosophila melanogaster
FBpp0305321 M9PF06 Drosophila melanogaster
FBpp0300693 B5DY71 Drosophila pseudoobscura
FBpp0309093 Q28Z97 Drosophila pseudoobscura
FBpp0309094 N6WBW7 Drosophila pseudoobscura
FBpp0277245 Q29FI8 Drosophila pseudoobscura
FBpp0285901 Q29CW6 Drosophila pseudoobscura