| Name | FERM/acyl-CoA-binding protein, 3-helical bundle | Short Name | FERM/acyl-CoA-bd_prot_3-hlx |
| Type | Domain | Description | This entry represents a structural domain with a core structure consisting of a 3-helical closed bundle with a left-handed twist, in an up-and-down arrangement. This structural motif occurs as subdomain 2 within FERM domains, as well as in acyl-CoA-binding proteins. The FERM domain (band F ezrin-radixin-moesin homology domains) has such a structure, acting as a common membrane-binding module involved in localising proteins to the plasma membrane []. Proteins containing FERM include cytoskeletal proteins such as erythrocyte membrane protein 4.1R, talin, and the ezrin-radixin-moesin protein family, as well as several protein tyrosine kinases and phosphatases, and the neurofibromatosis 2 tumour suppressor protein merlin. The ezrin-radixin-moesin protein family function is to crosslink the actin filaments of cytoskeletal structures to the plasma membrane.In addition, acyl-CoA-binding protein (ACBP) contains a domain with a similar 3-helical bundle structure. ACBP plays an important role in fatty acid metabolism, maintaining a pool of fatty acyl-CoA molecules in the cell []. |
| DB identifier | Name | Short Name | Type |
|---|---|---|---|
| IPR000582 | Acyl-CoA-binding protein, ACBP | Acyl-CoA-binding_protein | Domain |
| DB identifier | Name | Short Name | Type |
|---|---|---|---|
| IPR019749 | Band 4.1 domain | Band_41_domain | Domain |
| IPR000299 | FERM domain | FERM_domain | Domain |
| IPR019750 | Band 4.1 family | Band_41_fam | Family |
| IPR000798 | Ezrin/radixin/moesin like | Ez/rad/moesin_like | Family |
| IPR015788 | Moesin/ezrin/radixin homologue 2 | EMR2 | Family |
| IPR021187 | Band 4.1 protein | Band_41_protein | Family |
