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Protein Domain : IPR014352

Name  FERM/acyl-CoA-binding protein, 3-helical bundle Short Name  FERM/acyl-CoA-bd_prot_3-hlx
Type  Domain Description  This entry represents a structural domain with a core structure consisting of a 3-helical closed bundle with a left-handed twist, in an up-and-down arrangement. This structural motif occurs as subdomain 2 within FERM domains, as well as in acyl-CoA-binding proteins. The FERM domain (band F ezrin-radixin-moesin homology domains) has such a structure, acting as a common membrane-binding module involved in localising proteins to the plasma membrane []. Proteins containing FERM include cytoskeletal proteins such as erythrocyte membrane protein 4.1R, talin, and the ezrin-radixin-moesin protein family, as well as several protein tyrosine kinases and phosphatases, and the neurofibromatosis 2 tumour suppressor protein merlin. The ezrin-radixin-moesin protein family function is to crosslink the actin filaments of cytoskeletal structures to the plasma membrane.In addition, acyl-CoA-binding protein (ACBP) contains a domain with a similar 3-helical bundle structure. ACBP plays an important role in fatty acid metabolism, maintaining a pool of fatty acyl-CoA molecules in the cell [].

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR000582 Acyl-CoA-binding protein, ACBP Acyl-CoA-binding_protein Domain

2 Contains

DB identifier Name Short Name Type
IPR022408 Acyl-CoA-binding protein, ACBP, conserved site Acyl-CoA-binding_prot_CS Conserved_site
IPR019747 FERM conserved site FERM_CS Conserved_site

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
G3DSA:1.20.80.10 GENE3D IPR014352

2 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  

6 Found In

DB identifier Name Short Name Type
IPR019749 Band 4.1 domain Band_41_domain Domain
IPR000299 FERM domain FERM_domain Domain
IPR019750 Band 4.1 family Band_41_fam Family
IPR000798 Ezrin/radixin/moesin like Ez/rad/moesin_like Family
IPR015788 Moesin/ezrin/radixin homologue 2 EMR2 Family
IPR021187 Band 4.1 protein Band_41_protein Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

356 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0075035 Q9VVD2 Drosophila melanogaster
FBpp0076922 Q9VRG6 Drosophila melanogaster
FBpp0082261 Q9VFU8 Drosophila melanogaster
FBpp0073065 Q9VZI3 Drosophila melanogaster
FBpp0301157 Q9VWD5 Drosophila melanogaster
FBpp0079256 Q9VLS4 Drosophila melanogaster
FBpp0076624 P42281 Drosophila melanogaster
FBpp0076634 Q9VS20 Drosophila melanogaster
FBpp0076622 Q9VS21 Drosophila melanogaster
FBpp0080282 Q9V3Z6 Drosophila melanogaster
FBpp0089236 P46150 Drosophila melanogaster
FBpp0078914 Q9V3V3 Drosophila melanogaster
FBpp0074523 Q24564 Drosophila melanogaster
FBpp0077719 Q07436 Drosophila melanogaster
FBpp0079589 Q9VKY7 Drosophila melanogaster
FBpp0076623 Q9VS22 Drosophila melanogaster
FBpp0085697 Q9V8R9 Drosophila melanogaster
FBpp0077314 Q9VQI6 Drosophila melanogaster
FBpp0076318 Q9VSP9 Drosophila melanogaster
FBpp0290494 H5V8A7 Drosophila melanogaster
FBpp0303991 M9PHG2 Drosophila melanogaster
FBpp0300513 C7LAH9 Drosophila melanogaster
FBpp0290884 Q9VBX0 Drosophila melanogaster
FBpp0071748 Q8SWW8 Drosophila melanogaster
FBpp0288485 A8JPC8 Drosophila melanogaster
FBpp0112924 A0T1Z5 Drosophila melanogaster
FBpp0112923 A0T1Z4 Drosophila melanogaster
FBpp0112925 B7Z0J2 Drosophila melanogaster
FBpp0307779 Q9VN68 Drosophila melanogaster
FBpp0307778 Q2M1E6 Drosophila melanogaster