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Protein Domain : IPR010987

Name  Glutathione S-transferase, C-terminal-like Short Name  Glutathione-S-Trfase_C-like
Type  Domain Description  In eukaryotes, glutathione S-transferases (GSTs) participate in the detoxification of reactive electrophillic compounds by catalysing their conjugation to glutathione. GST is found as a domain in S-crystallins from squid, and proteins with no known GST activity, such as eukaryotic elongation factors 1-gamma and the HSP26 family of stress-related proteins, which include auxin-regulated proteins in plants and stringent starvation proteins in Escherichia coli. The major lens polypeptide of cephalopods is also a GST []. Bacterial GSTs of known function often have a specific, growth-supporting role in biodegradative metabolism: epoxide ring opening and tetrachlorohydroquinone reductive dehalogenation are two examples of the reactions catalysed by these bacterial GSTs. Some regulatory proteins, like the stringent starvation proteins, also belong to the GST family []. GST seems to be absent from Archaea in which gamma-glutamylcysteine substitute to glutathione as major thiol.Glutathione S-transferases form homodimers, but in eukaryotes can also form heterodimers of the A1 and A2 or YC1 and YC2 subunits. The homodimeric enzymes display a conserved structural fold. Each monomer is composed of a distinct N-terminal sub-domain, which adopts the thioredoxin fold, and a C-terminal all-helical sub-domain, which adopts a 4-helical bundle fold. This entry is the C-terminal domain.Glutaredoxin 2 (Grx2), glutathione-dependent disulphide oxidoreductases, is structurally similar to GSTs, even though they lack any sequence similarity. Grx2 is also composed of N and C-terminal subdomains. It is thought that the primary function of Grx2 is to catalyse reversible glutathionylation of proteins with glutathione in cellular redox regulation including the response to oxidative stress. Grx2 is dissimilar to other glutaredoxins apart from containing the conserved active site residues [].

Publication Counts Displayer

2 Child Features

DB identifier Name Short Name Type
IPR004046 Glutathione S-transferase, C-terminal GST_C Domain
IPR007494 Glutaredoxin 2, C-terminal Glutaredoxin2_C Domain

0 Contains

3 Cross References

Source . Name

Subject . Primary Identifier
PS50405 PROFILE IPR010987
G3DSA:1.20.1050.10 GENE3D IPR010987
SSF47616 SSF IPR010987

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

3 Found In

DB identifier Name Short Name Type
IPR017410 Mitochondrial outer membrane transport complex protein, metaxin Metaxin Family
IPR004526 Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic Glu-tRNA-synth_arc/euk Family
IPR003083 S-crystallin S-crystallin Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

583 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0085856 A1ZB72 Drosophila melanogaster
FBpp0076349 Q9VSL3 Drosophila melanogaster
FBpp0085852 A1ZB68 Drosophila melanogaster
FBpp0085851 Q7JYZ9 Drosophila melanogaster
FBpp0085857 A1ZB73 Drosophila melanogaster
FBpp0085853 A1ZB69 Drosophila melanogaster
FBpp0099646 P41043 Drosophila melanogaster
FBpp0081591 Q9VHB6 Drosophila melanogaster
FBpp0073609 Q8MRM0 Drosophila melanogaster
FBpp0081522 Q9VHD3 Drosophila melanogaster
FBpp0085850 Q7KK90 Drosophila melanogaster
FBpp0073666 Q9VY78 Drosophila melanogaster
FBpp0087548 Q7K0B6 Drosophila melanogaster
FBpp0085854 A1ZB70 Drosophila melanogaster
FBpp0085855 A1ZB71 Drosophila melanogaster
FBpp0085905 Q4V6J1 Drosophila melanogaster
FBpp0085858 Q7K8X7 Drosophila melanogaster
FBpp0113057 B7Z0S9 Drosophila melanogaster
FBpp0082048 Q8SXQ9 Drosophila melanogaster
FBpp0085876 Q7JVZ8 Drosophila melanogaster
FBpp0293853 Q9XYZ9 Drosophila melanogaster
FBpp0291657 Q7JVI6 Drosophila melanogaster
FBpp0086857 Q7JYX0 Drosophila melanogaster
FBpp0076376 Q9VSL6 Drosophila melanogaster
FBpp0076348 Q9VSL2 Drosophila melanogaster
FBpp0087549 A1Z7X7 Drosophila melanogaster
FBpp0081520 Q9VHD2 Drosophila melanogaster
FBpp0099824 P20432 Drosophila melanogaster
FBpp0099912 Q59E30 Drosophila melanogaster
FBpp0099913 Q59E29 Drosophila melanogaster