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Protein Domain : IPR001085

Name  Serine hydroxymethyltransferase Short Name  Ser_HO-MeTrfase
Type  Family Description  Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate (PLP) dependent enzyme and belongs to the aspartate aminotransferase superfamily (fold type I) []. The pyridoxal-P group is attached to a lysine residue around which the sequence is highly conserved in all forms of the enzyme []. The enzyme carries out interconversion of serine and glycine using PLP as the cofactor. SHMT catalyses the transfer of a hydroxymethyl group from N5, N10- methylene tetrahydrofolate to glycine, resulting in the formation of serine and tetrahydrofolate. Both eukaryotic and prokaryotic SHMT enzymes form tight obligate homodimers and the mammalian enzyme forms a homotetramer [, ].

Publication Counts Displayer

0 Child Features

2 Contains

DB identifier Name Short Name Type
IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 PyrdxlP-dep_Trfase_major_sub1 Domain
IPR019798 Serine hydroxymethyltransferase, pyridoxal phosphate binding site Ser_HO-MeTrfase_PLP_BS Binding_site

4 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR11680 PANTHER IPR001085
PF00464 PFAM IPR001085
PIRSF000412 PIRSF IPR001085
MF_00051 HAMAP IPR001085

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Serine hydroxymethyltransferase   GO:0004372 glycine hydroxymethyltransferase activity
Serine hydroxymethyltransferase   GO:0006544 glycine metabolic process
Serine hydroxymethyltransferase   GO:0006563 L-serine metabolic process

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Serine hydroxymethyltransferase   GO:0004372 glycine hydroxymethyltransferase activity
Serine hydroxymethyltransferase   GO:0006544 glycine metabolic process
Serine hydroxymethyltransferase   GO:0006563 L-serine metabolic process

0 Parent Features

12 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0288674 B7Z0X1 Drosophila melanogaster
FBpp0070792 Q9W457 Drosophila melanogaster
FBpp0272231 Q29H49 Drosophila pseudoobscura
FBpp0164485 B4L1H0 Drosophila mojavensis
FBpp0229258 B4MEL9 Drosophila virilis
FBpp0260694 B4Q1E6 Drosophila yakuba
GLYC_CAEBR Q60V73 Caenorhabditis briggsae
H2W4W2_CAEJA H2W4W2 Caenorhabditis japonica
G0MLS6_CAEBE G0MLS6 Caenorhabditis brenneri
GLYC_CAEEL P50432 Caenorhabditis elegans
GLYC_CAEEL-2 P50432-2 Caenorhabditis elegans
E3LWY9_CAERE E3LWY9 Caenorhabditis remanei