modENCODE |  Help |  blog

Protein Domain : IPR015422

Name  Pyridoxal phosphate-dependent transferase, major region, subdomain 2 Short Name  PyrdxlP-dep_Trfase_major_sub2
Type  Domain Description  Pyridoxal phosphate is the active form of vitamin B6 (pyridoxine or pyridoxal). Pyridoxal 5'-phosphate (PLP) is a versatile catalyst, acting as a coenzyme in a multitude of reactions, including decarboxylation, deamination and transamination [, , ]. PLP-dependent enzymes are primarily involved in the biosynthesis of amino acids and amino acid-derived metabolites, but they are also found in the biosynthetic pathways of amino sugars and in the synthesis or catabolism of neurotransmitters; pyridoxal phosphate can also inhibit DNA polymerases and several steroid receptors []. Inadequate levels of pyridoxal phosphate in the brain can cause neurological dysfunction, particularly epilepsy [].PLP enzymes exist in their resting state as a Schiff base, the aldehyde group of PLP forming a linkage with the epsilon-amino group of an active site lysine residue on the enzyme. The alpha-amino group of the substrate displaces the lysine epsilon-amino group, in the process forming a new aldimine with the substrate. This aldimine is the common central intermediate for all PLP-catalysed reactions, enzymatic and non-enzymatic [].This entry represents subdomain 2 of the major region of PLP-dependent transferases. This domain has a complex alpha/beta structure. The major region can be found in the following PLP-dependent transferase families:Aspartate aminotransferase (AAT)-like enzymes, such as aromatic aminoacid aminotransferase AroAT, glutamine aminotransferase and kynureninase [].Beta-eliminating lyases, such as tyrosine phenol lyase and tryptophanase [].Pyridoxal-dependent decarboxylases, such as DOPA decarboxylase and glutamate decarboxylase beta (GadB) [].Cystathionine synthase-like enzymes, such as cystalysin, methionine gamma-lyase (MGL), and cysteine desulphurase (IscS) [].GABA-aminotransferase-like enzymes, such as ornithine aminotransferase and serine hydroxymethyltransferase [].Ornithine decarboxylase major domain [].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
G3DSA:3.90.1150.10 GENE3D IPR015422

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

22 Found In

DB identifier Name Short Name Type
IPR015424 Pyridoxal phosphate-dependent transferase PyrdxlP-dep_Trfase Domain
IPR002129 Pyridoxal phosphate-dependent decarboxylase PyrdxlP-dep_de-COase Family
IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme Cys/Met-Metab_PyrdxlP-dep_enz Family
IPR022278 Phosphoserine aminotransferase Pser_aminoTfrase Family
IPR003248 Phosphoserine aminotransferase, subgroup Pser_aminoTfrase_subgr Family
IPR021178 Tyrosine transaminase Tyrosine_transaminase Family
IPR006233 Cystathionine beta-lyase, bacterial Cys_b_lyase_bac Family
IPR011193 Ornithine/lysine/arginine decarboxylase Orn/lys/arg_de-COase Family
IPR000310 Orn/Lys/Arg decarboxylase, major domain Orn/Lys/Arg_deCO2ase_major_dom Domain
IPR019881 Diaminopimelate aminotransferase, DapL, Desulfovibrio-type DAP-NH2Trfase_DapL_Desulfo Family
IPR006948 Allinase, C-terminal Alliinase_C Domain
IPR022517 Aspartate 1-decarboxylase, pyridoxal-dependent Asp_decarboxylase_pyridox Family
IPR019942 LL-diaminopimelate aminotransferase, plants and Chlamydia type DapL_aminotrans Family
IPR020026 Pseudaminic acid biosynthesis, PseC Pseudaminic_synth_PseC Family
IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase DegT/StrS_aminotransferase Family
IPR012749 TDP-4-keto-6-deoxy-D-glucose transaminase ECA_WecE Family
IPR005860 L-threonine-O-3-phosphate decarboxylase CobD Family
IPR011821 O-succinylhomoserine (thiol)-lyase O_succ_thio_ly Family
IPR006238 Cystathionine beta-lyase, eukaryotic Cys_b_lyase_euk Family
IPR006237 Methionine gamma-lyase Met_gamma_lys Family
IPR006235 O-acetylhomoserine/O-acetylserine sulfhydrylase OAc-hSer/O-AcSer_sulfhydrylase Family
IPR006234 O-succinylhomoserine sulfhydrylase O-succ-hSer_sulfhydrylase Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Pyridoxal phosphate-dependent transferase, major region, subdomain 2   GO:0003824 catalytic activity
Pyridoxal phosphate-dependent transferase, major region, subdomain 2   GO:0030170 pyridoxal phosphate binding

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Pyridoxal phosphate-dependent transferase, major region, subdomain 2   GO:0003824 catalytic activity
Pyridoxal phosphate-dependent transferase, major region, subdomain 2   GO:0030170 pyridoxal phosphate binding

0 Parent Features

347 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0073600 Q9VYD9 Drosophila melanogaster
FBpp0073605 Q7KV27 Drosophila melanogaster
FBpp0079874 Q9VKD3 Drosophila melanogaster
FBpp0070875 Q9W3Z3 Drosophila melanogaster
FBpp0085476 A1Z6N2 Drosophila melanogaster
FBpp0288674 B7Z0X1 Drosophila melanogaster
FBpp0070792 Q9W457 Drosophila melanogaster
FBpp0074729 Q9VW26 Drosophila melanogaster
FBpp0084759 Q9VAN0 Drosophila melanogaster
FBpp0080297 Q9V3F2 Drosophila melanogaster
FBpp0085889 Q7JXZ2 Drosophila melanogaster
FBpp0080698 P18486 Drosophila melanogaster
FBpp0080697 Q9VIZ9 Drosophila melanogaster
FBpp0087422 Q05733 Drosophila melanogaster
FBpp0073133 P20228 Drosophila melanogaster
FBpp0078188 Q9VNR7 Drosophila melanogaster
FBpp0073725 Q9VY42 Drosophila melanogaster
FBpp0075815 Q9VTN9 Drosophila melanogaster
FBpp0080709 F0JAJ7 Drosophila melanogaster
FBpp0080710 P05031 Drosophila melanogaster
FBpp0075543 Q9VU95 Drosophila melanogaster
FBpp0076998 Q9VRA2 Drosophila melanogaster
FBpp0074677 Q9VW68 Drosophila melanogaster
FBpp0081996 Q8SXC2 Drosophila melanogaster
FBpp0085475 A1Z6N4 Drosophila melanogaster
FBpp0083872 Q9VCK6 Drosophila melanogaster
FBpp0080119 Q24062 Drosophila melanogaster
FBpp0075971 Q9VTD9 Drosophila melanogaster
FBpp0072060 O18680 Drosophila melanogaster
FBpp0077837 Q9VPH6 Drosophila melanogaster