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Protein Domain : IPR015421

Name  Pyridoxal phosphate-dependent transferase, major region, subdomain 1 Short Name  PyrdxlP-dep_Trfase_major_sub1
Type  Domain Description  Pyridoxal phosphate is the active form of vitamin B6 (pyridoxine or pyridoxal). Pyridoxal 5'-phosphate (PLP) is a versatile catalyst, acting as a coenzyme in a multitude of reactions, including decarboxylation, deamination and transamination [, , ]. PLP-dependent enzymes are primarily involved in the biosynthesis of amino acids and amino acid-derived metabolites, but they are also found in the biosynthetic pathways of amino sugars and in the synthesis or catabolism of neurotransmitters; pyridoxal phosphate can also inhibit DNA polymerases and several steroid receptors []. Inadequate levels of pyridoxal phosphate in the brain can cause neurological dysfunction, particularly epilepsy [].PLP enzymes exist in their resting state as a Schiff base, the aldehyde group of PLP forming a linkage with the epsilon-amino group of an active site lysine residue on the enzyme. The alpha-amino group of the substrate displaces the lysine epsilon-amino group, in the process forming a new aldimine with the substrate. This aldimine is the common central intermediate for all PLP-catalysed reactions, enzymatic and non-enzymatic [].This entry represents subdomain 1 of the major region of PLP-dependent transferases. This domain has a 3-layer alpha/beta/alpha sandwich topology. The major region can be found in the following PLP-dependent transferase families:Aspartate aminotransferase (AAT)-like enzymes, such as aromatic aminoacid aminotransferase AroAT, glutamine aminotransferase and kynureninase [].Beta-eliminating lyases, such as tyrosine phenol lyase and tryptophanase [].Pyridoxal-dependent decarboxylases, such as DOPA decarboxylase and glutamate decarboxylase beta (GadB) [].Cystathionine synthase-like enzymes, such as cystalysin, methionine gamma-lyase (MGL), and cysteine desulphurase (IscS) [].GABA-aminotransferase-like enzymes, such as ornithine aminotransferase and serine hydroxymethyltransferase [].Ornithine decarboxylase major domain [].

Publication Counts Displayer

0 Child Features

6 Contains

DB identifier Name Short Name Type
IPR019798 Serine hydroxymethyltransferase, pyridoxal phosphate binding site Ser_HO-MeTrfase_PLP_BS Binding_site
IPR021115 Pyridoxal-phosphate binding site Pyridoxal-P_BS Binding_site
IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site NHTrfase_class1_PyrdxlP-BS Binding_site
IPR020578 Aminotransferase class-V pyridoxal-phosphate binding site Aminotrans_V_PyrdxlP_BS Binding_site
IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site Aminotrans_II_pyridoxalP_BS Binding_site
IPR018176 Tryptophanase, conserved site Tryptophanase_CS Conserved_site

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
G3DSA:3.40.640.10 GENE3D IPR015421

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

76 Found In

DB identifier Name Short Name Type
IPR015424 Pyridoxal phosphate-dependent transferase PyrdxlP-dep_Trfase Domain
IPR001085 Serine hydroxymethyltransferase Ser_HO-MeTrfase Family
IPR000192 Aminotransferase, class V/Cysteine desulfurase Aminotrans_V/Cys_dSase Domain
IPR010111 Kynureninase Kynureninase Family
IPR008829 Soluble liver antigen/liver pancreas antigen SLA/LP_auto_ag Family
IPR002129 Pyridoxal phosphate-dependent decarboxylase PyrdxlP-dep_de-COase Family
IPR010977 Aromatic-L-amino-acid decarboxylase Aromatic_deC Family
IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme Cys/Met-Metab_PyrdxlP-dep_enz Family
IPR004631 4-aminobutyrate aminotransferase, eukaryotic 4NH2But_aminotransferase_euk Family
IPR005814 Aminotransferase class-III Aminotrans_3 Family
IPR004839 Aminotransferase, class I/classII Aminotransferase_I/II Domain
IPR000796 Aspartate/other aminotransferase Asp_trans Family
IPR016454 Cysteine desulfurase, NifS Cysteine_dSase_NifS Family
IPR010240 Cysteine desulfurase Cys_deSase Family
IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase ArAA_b-elim_lyase/Thr_aldolase Domain
IPR010164 Ornithine aminotransferase Orn_aminotrans Family
IPR022278 Phosphoserine aminotransferase Pser_aminoTfrase Family
IPR003248 Phosphoserine aminotransferase, subgroup Pser_aminoTfrase_subgr Family
IPR020580 Glycine cleavage system P-protein, N-terminal GDC-P_N Domain
IPR020581 Glycine cleavage system P protein GDC_P Family
IPR003437 Glycine cleavage system P protein, homodimeric GDC_P_homo Family
IPR005958 Tyrosine/nicotianamine aminotransferase TyrNic_aminoTrfase Domain
IPR005957 Tyrosine aminotransferase Tyrosine_aminoTrfase Domain
IPR021178 Tyrosine transaminase Tyrosine_transaminase Family
IPR011282 2-amino-3-ketobutyrate coenzyme A ligase 2am3keto_CoA_ligase Family
IPR010961 Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase 4pyrrol_synth_NH2levulA_synth Domain
IPR005861 Histidinol-phosphate aminotransferase family HisP_aminotrans Family
IPR019878 Succinyldiaminopimelate transaminase, DapC, beta/gammaproteobacteria DapC_beta/gammaproteobac Family
IPR006233 Cystathionine beta-lyase, bacterial Cys_b_lyase_bac Family
IPR020931 Tyrosine decarboxylase Tyr_deCO2ase Family

2 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Pyridoxal phosphate-dependent transferase, major region, subdomain 1   GO:0003824 catalytic activity
Pyridoxal phosphate-dependent transferase, major region, subdomain 1   GO:0030170 pyridoxal phosphate binding

2 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Pyridoxal phosphate-dependent transferase, major region, subdomain 1   GO:0003824 catalytic activity
Pyridoxal phosphate-dependent transferase, major region, subdomain 1   GO:0030170 pyridoxal phosphate binding

0 Parent Features

474 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0073600 Q9VYD9 Drosophila melanogaster
FBpp0073605 Q7KV27 Drosophila melanogaster
FBpp0079874 Q9VKD3 Drosophila melanogaster
FBpp0070875 Q9W3Z3 Drosophila melanogaster
FBpp0085476 A1Z6N2 Drosophila melanogaster
FBpp0288674 B7Z0X1 Drosophila melanogaster
FBpp0070792 Q9W457 Drosophila melanogaster
FBpp0086371 Q7K221 Drosophila melanogaster
FBpp0086370 A1ZAA5 Drosophila melanogaster
FBpp0074729 Q9VW26 Drosophila melanogaster
FBpp0077536 Q9VQ61 Drosophila melanogaster
FBpp0077537 Q8IPY3 Drosophila melanogaster
FBpp0086158 Q9V7Y2 Drosophila melanogaster
FBpp0084759 Q9VAN0 Drosophila melanogaster
FBpp0080297 Q9V3F2 Drosophila melanogaster
FBpp0085889 Q7JXZ2 Drosophila melanogaster
FBpp0080698 P18486 Drosophila melanogaster
FBpp0080697 Q9VIZ9 Drosophila melanogaster
FBpp0087422 Q05733 Drosophila melanogaster
FBpp0073133 P20228 Drosophila melanogaster
FBpp0076891 Q9VRG8 Drosophila melanogaster
FBpp0081703 Q9VH09 Drosophila melanogaster
FBpp0078188 Q9VNR7 Drosophila melanogaster
FBpp0073725 Q9VY42 Drosophila melanogaster
FBpp0075815 Q9VTN9 Drosophila melanogaster
FBpp0080709 F0JAJ7 Drosophila melanogaster
FBpp0080710 P05031 Drosophila melanogaster
FBpp0075543 Q9VU95 Drosophila melanogaster
FBpp0076998 Q9VRA2 Drosophila melanogaster
FBpp0074677 Q9VW68 Drosophila melanogaster