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Protein Domain : IPR006186

Name  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase Short Name  Ser/Thr-sp_prot-phosphatase
Type  Domain Description  Protein phosphorylation plays a central role in the regulation of cell functions [], causing the activation or inhibition of many enzymes involved in various biochemical pathways []. Kinases and phosphatases are the enzymes responsible for this, and may themselves be subject to control through the action of hormones and growth factors []. Serine/threonine(S/T) phosphatases () catalyse the dephosphorylation of phosphoserine and phosphothreonine residues. In mammalian tissues four different types of PP have been identified and are known as PP1, PP2A, PP2B and PP2C. Except for PP2C, these enzymes are evolutionary related. The catalytic regions of the proteins arewell conserved and have a slow mutation rate, suggesting that major changes in these regions are highly detrimental [].Protein phosphatase-1 (PP1) and protein phosphatase-2A (PP2A) have a broad specificity and there are two closely related isoforms of each, alpha and beta. PP2A is a trimeric enzyme that consists of a core composed of a catalytic subunit associated with a 65 kDa regulatory subunit and a third variable subunit. Protein phosphatase-2B (PP2B or calcineurin), a calcium-dependent enzyme whose activity is stimulated by calmodulin, is composed of two subunits the catalytic A-subunit and the calcium-binding B-subunit. The specificity of PP2B is restricted. Other serine/threonine specific protein phosphatases that have been characterised include mammalian phosphatase-X (PP-X), and Drosophila phosphatase-V (PP-V), which are closely related but yet distinct from PP2A; yeast phosphatase PPH3, which is similar to PP2A, but with different enzymatic properties; and Drosophila phosphatase-Y (PP-Y), and yeastphosphatases Z1 and Z2 which are closely related but yet distinct from PP1.

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PR00114 PRINTS IPR006186
PS00125 PROSITE IPR006186
SM00156 SMART IPR006186

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

4 Found In

DB identifier Name Short Name Type
IPR012008 Serine/threonine protein phosphatase, EF-hand-containing Ser/Thr-Pase_EF-hand_contain Family
IPR011236 Serine/threonine protein phosphatase 5 Ser/Thr_PPase_5 Family
IPR011159 Phosphoprotein phosphatase PPZ PPPtase_PPZ Family
IPR012391 Serine/threonine protein phosphatase, BSU1 Ser/Thr_prot_Pase_BSU1 Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase   GO:0016787 hydrolase activity

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase   GO:0016787 hydrolase activity

1 Parent Features

DB identifier Name Short Name Type
IPR004843 Calcineurin-like phosphoesterase domain, apaH type Calcineurin-like_PHP_apaH Domain

394 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0081606 Q9VH81 Drosophila melanogaster
FBpp0085996 P11612 Drosophila melanogaster
FBpp0071650 Q7KVM5 Drosophila melanogaster
FBpp0071381 Q8T0U6 Drosophila melanogaster
FBpp0305497 P48462 Drosophila melanogaster
FBpp0084026 P48461 Drosophila melanogaster
FBpp0079148 P23696 Drosophila melanogaster
FBpp0074069 Q27889 Drosophila melanogaster
FBpp0073834 Q05547 Drosophila melanogaster
FBpp0085094 P48456 Drosophila melanogaster
FBpp0077017 O76932 Drosophila melanogaster
FBpp0075812 Q95TV5 Drosophila melanogaster
FBpp0070883 Q27884 Drosophila melanogaster
FBpp0071719 Q9W2A5 Drosophila melanogaster
FBpp0074067 Q9VXF1 Drosophila melanogaster
FBpp0077344 Q9VQL9 Drosophila melanogaster
FBpp0082067 P12982 Drosophila melanogaster
FBpp0309720 P40421 Drosophila melanogaster
FBpp0302590 Q5LJN2 Drosophila melanogaster
FBpp0276047 B5E0J4 Drosophila pseudoobscura
FBpp0306101 B5E0M4 Drosophila pseudoobscura
FBpp0280021 B5DIB4 Drosophila pseudoobscura
FBpp0273551 Q29IJ2 Drosophila pseudoobscura
FBpp0274425 B5DPJ5 Drosophila pseudoobscura
FBpp0273565 Q29IH5 Drosophila pseudoobscura
FBpp0278487 B5E0J5 Drosophila pseudoobscura
FBpp0282981 B5DX15 Drosophila pseudoobscura
FBpp0282147 B5DYB4 Drosophila pseudoobscura
FBpp0282205 B5DMS4 Drosophila pseudoobscura
FBpp0272252 B5DMX9 Drosophila pseudoobscura