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Protein Domain : IPR016040

Name  NAD(P)-binding domain Short Name  NAD(P)-bd_dom
Type  Domain Description  This entry represents NAD- and NADP-binding domains with a core Rossmann-type fold, which consists of 3-layers alpha/beta/alpha, where the six beta strands are parallel in the order 321456. Many different enzymes contain an NAD/NADP-binding domain, including:C-terminal domain of alcohol dehydrogenases []Tyrosine-dependent oxidoreductases (also known as short-chain dehydrogenases) []N-terminal domain of glyceraldehyde-3-phosphate dehydrogenase []NAD-binding domain of formate/glycerate dehydrogenases []N-terminal domain of sirohaem synthase []N-terminal domain of lactate dehydrogenase []N-terminal domain of 6-phosphogluconate dehydrogenase (the beta-sheet is extended to 8 strands) []C-terminal domain of amino acid dehydrogenases (an extra N-terminal helix displaces the C-terminal helix []NAD-binding domain of certain potassium channels []C-terminal domain of the transcriptional repressor Rex []Ornithine cyclodeaminase []CoA-binding N-terminal domain of the alpha chain of succinyl-CoA synthetase []

Publication Counts Displayer

22 Child Features

DB identifier Name Short Name Type
IPR009036 Molybdenum cofactor biosynthesis, MoeB Molybdenum_cofac_synth_MoeB Domain
IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding D-isomer_2_OHA_DH_NAD-bd Domain
IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding 3-OHacyl-CoA_DH_NAD-bd Domain
IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal G3P_DH_NAD-dep_N Domain
IPR020842 Polyketide synthase/Fatty acid synthase, KR PKS/FAS_KR Domain
IPR003781 CoA-binding CoA-bd Domain
IPR006115 6-phosphogluconate dehydrogenase, NADP-binding 6PGDH_NADP-bd Domain
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DH/CycHdrlase_NAD-bd_dom Domain
IPR001236 Lactate/malate dehydrogenase, N-terminal Lactate/malate_DH_N Domain
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase 3Beta_OHSteriod_DH/Estase Domain
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal ProC_N Domain
IPR022674 Glucose-6-phosphate dehydrogenase, NAD-binding G6P_DH_NAD-bd Domain
IPR012302 Malic enzyme, NAD-binding Malic_NAD-bd Domain
IPR013120 Male sterility, NAD-binding Male_sterile_NAD-bd Domain
IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal UDP-Glc/GDP-Man_DH_N Domain
IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal Glu/Leu/Phe/Val_DH_C Domain
IPR006151 Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase Shikm_DH/Glu-tRNA_Rdtase Domain
IPR013332 Ketopantoate reductase ApbA/PanE, N-terminal ApbA_N Domain
IPR003869 Polysaccharide biosynthesis protein, CapD-like domain Polysac_CapD-like Domain
IPR000846 Dihydrodipicolinate reductase, N-terminal DapB_N Domain
IPR006367 Sirohaem synthase, N-terminal Sirohaem_synthase_N Domain
IPR019665 Putative oxidoreductase/dehydrogenase, Rossmann-like domain OxRdtase/DH_put_Rossmann_dom Domain

18 Contains

DB identifier Name Short Name Type
IPR020830 Glyceraldehyde 3-phosphate dehydrogenase, active site GlycerAld_3-P_DH_AS Active_site
IPR020904 Short-chain dehydrogenase/reductase, conserved site Sc_DH/Rdtase_CS Conserved_site
IPR006181 D-amino acid oxidase, conserved site D-amino_acid_oxidase_CS Conserved_site
IPR019572 Ubiquitin-activating enzyme Ubiquitin-activating_enzyme Domain
IPR018074 Ubiquitin-activating enzyme, E1, active site UBQ-activ_enz_E1_AS Active_site
IPR008143 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 Ala_DH/PNT_CS2 Conserved_site
IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site 3-OH-isobutyrate_DH-rel_CS Conserved_site
IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site THF_DH/CycHdrlase_CS Conserved_site
IPR020082 S-adenosyl-L-homocysteine hydrolase, conserved site S-Ado-L-homoCys_hydrolase_CS Conserved_site
IPR019796 Glucose-6-phosphate dehydrogenase, active site G6P_DH_AS Active_site
IPR015884 Malic enzyme, conserved site Malic_enzyme_CS Conserved_site
IPR013021 Myo-inositol-1-phosphate synthase, GAPDH-like Myo-inos-1-P_Synthase_GAPDH Domain
IPR000683 Oxidoreductase, N-terminal Oxidoreductase_N Domain
IPR013549 Domain of unknown function DUF1731, C-terminal DUF1731_C Domain
IPR003148 Regulator of K+ conductance, N-terminal RCK_N Domain
IPR006037 Regulator of K+ conductance, C-terminal RCK_C Domain
IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site Quin_OxRdtase/zeta-crystal_CS Conserved_site
IPR013131 Mannitol dehydrogenase, N-terminal Mannitol_DH_N Domain

1 Cross References

Source . Name

Subject . Primary Identifier

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

94 Found In

DB identifier Name Short Name Type
IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GlycerAld/Erythrose_P_DH Family
IPR006424 Glyceraldehyde-3-phosphate dehydrogenase, type I Glyceraldehyde-3-P_DH_1 Family
IPR006368 GDP-mannose 4,6-dehydratase GDP_Man_deHydtase Family
IPR002198 Short-chain dehydrogenase/reductase SDR DH_sc/Rdtase_SDR Family
IPR002347 Glucose/ribitol dehydrogenase Glc/ribitol_DH Family
IPR003929 Potassium channel, calcium-activated, BK, alpha subunit K_chnl_Ca-activ_BK_asu Family
IPR005886 UDP-glucose 4-epimerase GalE GalE Family
IPR022694 3-hydroxyacyl-CoA dehydrogenase 3-OHacyl-CoA_DH Family
IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase THF_DH/CycHdrlase Family
IPR001557 L-lactate/malate dehydrogenase L-lactate/malate_DH Family
IPR011304 L-lactate dehydrogenase L-lactate_DH Family
IPR000304 Pyrroline-5-carboxylate reductase Pyrroline-COOH_reductase Family
IPR001282 Glucose-6-phosphate dehydrogenase G6P_DH Family
IPR001891 Malic oxidoreductase Malic_OxRdtase Family
IPR018075 Ubiquitin-activating enzyme, E1 UBQ-activ_enz_E1 Family
IPR002587 Myo-inositol-1-phosphate synthase Myo-inos-1-P_Synthase Family
IPR017476 UDP-glucose/GDP-mannose dehydrogenase UDP-Glc/GDP-Man Family
IPR011274 Malate dehydrogenase, NAD-dependent, cytosolic Malate_DH_NAD-dep_euk Family
IPR010945 Malate dehydrogenase, type 2 Malate_DH_type2 Family
IPR005888 dTDP-glucose 4,6-dehydratase dTDP_Gluc_deHydtase Family
IPR005097 Saccharopine dehydrogenase / Homospermidine synthase Saccharopine_DH/HSpermid_syn Family
IPR010097 Malate dehydrogenase, type 1 Malate_DH_type1 Family
IPR002425 Alcohol dehydrogenase, Drosophila-type ADH_Drosophila-type Family
IPR002424 Alcohol dehydrogenase, insect-type ADH_insect Family
IPR002426 Alcohol dehydrogenase, Ceratitis-type ADH_Ceratitis-type Family
IPR002427 Alcohol dehydrogenase-related ADH-rel Family
IPR008089 Nucleotide sugar epimerase Nuc_sugar_epim Family
IPR010099 Sugar nucleotide epimerase YfcH,-like putative Sugar_nucleotide_Epase_put Family
IPR011182 Aspartate dehydrogenase, NAD biosynthesis Asp_DH_NAD_syn Family
IPR003462 Ornithine cyclodeaminase/mu-crystallin ODC_Mu_crystall Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

2252 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0087993 Q7JUS1 Drosophila melanogaster
FBpp0088031 Q961L4 Drosophila melanogaster
FBpp0088032 Q0E9G4 Drosophila melanogaster
FBpp0297771 Q9W0P5 Drosophila melanogaster
FBpp0070179 Q9U1L2 Drosophila melanogaster
FBpp0079295 Q9VLJ8 Drosophila melanogaster
FBpp0078779 M9PET0 Drosophila melanogaster
FBpp0078778 M9PC43 Drosophila melanogaster
FBpp0078777 B5RIM9 Drosophila melanogaster
FBpp0291083 Q86NT5 Drosophila melanogaster
FBpp0081638 Q9VH72 Drosophila melanogaster
FBpp0099514 O46036 Drosophila melanogaster
FBpp0071131 Q9W3H4 Drosophila melanogaster
FBpp0082073 Q95T70 Drosophila melanogaster
FBpp0082074 Q9VG87 Drosophila melanogaster
FBpp0081141 O97479 Drosophila melanogaster
FBpp0290087 Q9VES5 Drosophila melanogaster
FBpp0292069 Q7KT11 Drosophila melanogaster
FBpp0292071 Q8SZU0 Drosophila melanogaster
FBpp0087206 Q7K4C2 Drosophila melanogaster
FBpp0309547 Q9VKB8 Drosophila melanogaster
FBpp0080952 Q8INU6 Drosophila melanogaster
FBpp0078356 Q8SX57 Drosophila melanogaster
FBpp0070368 M9PIS3 Drosophila melanogaster
FBpp0087129 Q7K3N4 Drosophila melanogaster
FBpp0081800 O96299 Drosophila melanogaster
FBpp0300159 Q9I7R3 Drosophila melanogaster
FBpp0099966 Q2MGJ8 Drosophila melanogaster
FBpp0099972 Q9VSU6 Drosophila melanogaster
FBpp0084714 Q8MS59 Drosophila melanogaster