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Protein Domain : IPR019734

Name  Tetratricopeptide repeat Short Name  TPR_repeat
Type  Repeat Description  The tetratrico peptide repeat region (TPR) is a structural motif present in a wide range of proteins [, , ]. It mediates protein-protein interactions and the assembly of multiprotein complexes []. The TPR motifconsists of 3-16 tandem-repeats of 34 amino acids residues, although individual TPR motifs canbe dispersed in the protein sequence. Sequence alignment of the TPR domains reveals aconsensus sequence defined by a pattern of small and large amino acids. TPR motifs have beenidentified in various different organisms, ranging from bacteria to humans. Proteins containingTPRs are involved in a variety of biological processes, such as cell cycle regulation,transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis andprotein folding.The X-ray structure of a domain containing three TPRs from protein phosphatase 5 revealed thatTPR adopts a helix-turn-helix arrangement, with adjacent TPR motifs packing in a parallelfashion, resulting in a spiral of repeating anti-parallel alpha-helices []. The two helices are denotedhelix A and helix B. The packing angle between helix A and helix B is ~24 degrees within asingle TPR and generates a right-handed superhelical shape. Helix A interacts with helix B andwith helix A' of the next TPR. Two protein surfaces are generated: the inner concave surface iscontributed to mainly by residue on helices A, and the other surface presents residues from bothhelices A and B.

Publication Counts Displayer

0 Child Features

0 Contains

5 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF13174 PFAM IPR019734
PF13176 PFAM IPR019734
PF13181 PFAM IPR019734
PS50005 PROFILE IPR019734
SM00028 SMART IPR019734

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

5 Found In

DB identifier Name Short Name Type
IPR021183 N-terminal acetyltransferase A, auxiliary subunit NatA_aux_su Family
IPR019544 Tetratricopeptide, SHNi-TPR domain Tetratricopeptide_SHNi-TPR_dom Domain
IPR001237 43kDa postsynaptic protein Postsynaptic Family
IPR019568 Rapsyn, myristoylation/linker region, N-terminal Rapsyn_myristoylation/link_N Domain
IPR015374 Chs5p-Arf1p binding ChAPs Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tetratricopeptide repeat   GO:0005515 protein binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Tetratricopeptide repeat   GO:0005515 protein binding

0 Parent Features

640 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0074480 Q9VWI2 Drosophila melanogaster
FBpp0070351 O46085 Drosophila melanogaster
FBpp0070352 Q7KW08 Drosophila melanogaster
FBpp0081606 Q9VH81 Drosophila melanogaster
FBpp0080894 Q9I7L8 Drosophila melanogaster
FBpp0083769 Q9VCN6 Drosophila melanogaster
FBpp0110159 Q0KHY6 Drosophila melanogaster
FBpp0085046 Q8IMI2 Drosophila melanogaster
FBpp0085923 Q7K7W5 Drosophila melanogaster
FBpp0080003 Q9VK45 Drosophila melanogaster
FBpp0307598 M9PFS0 Drosophila melanogaster
FBpp0087297 A1Z8E9 Drosophila melanogaster
FBpp0070906 Q9W3Y7 Drosophila melanogaster
FBpp0080535 Q9VJD4 Drosophila melanogaster
FBpp0079893 Q9VKC8 Drosophila melanogaster
FBpp0085033 Q9VA50 Drosophila melanogaster
FBpp0081805 Q9VGU5 Drosophila melanogaster
FBpp0073411 Q9VYT2 Drosophila melanogaster
FBpp0303439 Q8IR85 Drosophila melanogaster
FBpp0085047 Q9VA61 Drosophila melanogaster
FBpp0085842 Q7K3D4 Drosophila melanogaster
FBpp0082765 Q9VEV3 Drosophila melanogaster
FBpp0082652 Q8IND4 Drosophila melanogaster
FBpp0084440 Q9VBA1 Drosophila melanogaster
FBpp0075683 P46824 Drosophila melanogaster
FBpp0079468 Q9VL78 Drosophila melanogaster
FBpp0070907 Q9W3Y6 Drosophila melanogaster
FBpp0077614 Q9V3X5 Drosophila melanogaster
FBpp0293601 A8DYS8 Drosophila melanogaster
FBpp0077790 Q9VPN5 Drosophila melanogaster