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Protein Domain : IPR000717

Name	Proteasome component (PCI) domain	Short Name	PCI_dom
Type	Domain	Description	A homology domain of unclear function, occurs in the C-terminal region of severalregulatory components of the 26S proteasome as well as in other proteins. This domainhas also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15) [].Apparently, all of the characterised proteins containing PCI domains are parts of largermulti-protein complexes. Proteins with PCI domains include budding yeast proteasomeregulatory components Rpn3(Sun2), Rpn5, Rpn6, Rpn7and Rpn9 []; mammalian proteasome regulatory components p55, p58 and p44.5, and translationinitiation factor 3 complex subunits p110 and INT6 [, ]; ArabidopsisCOP9 and FUS6/COP11 []; mammalian G-protein pathway suppressor GPS1, and severaluncharacterised ORFs from plant, nematodes and mammals. The complete homology domain comprisesapprox. 200 residues, the highest conservation is found in the C-terminal half. Several of theproteins mentioned above have no detectable homology to the N-terminal half of the domain.

Publication Counts Displayer

0 Child Features

1 Contains

DB identifier	Name	Short Name	Type
IPR011991	Winged helix-turn-helix DNA-binding domain	WHTH_DNA-bd_dom	Domain

2 Cross References

Identifier	Source . Name	Subject . Primary Identifier
PF01399	PFAM	IPR000717
SM00088	SMART	IPR000717

3 Data Sets

Name	URL
Swiss-Prot data set	http://ca.expasy.org/sprot
InterPro data set
InterPro GO Annotation data set

1 Found In

DB identifier	Name	Short Name	Type
IPR016650	Eukaryotic translation initiation factor 3 subunit E	eIF3e	Family

1 GO Annotation

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	Proteasome component (PCI) domain		GO:0005515	protein binding

1 Ontology Annotations

Subject . Secondary Identifier	Subject . Name	Subject . Symbol	Ontology Term . Identifier	Ontology Term . Name
	Proteasome component (PCI) domain		GO:0005515	protein binding

0 Parent Features

164 Proteins

DB identifier	Primary Accession	Organism . Name
FBpp0086013	A1ZAX1	Drosophila melanogaster
FBpp0087821	Q9V4S8	Drosophila melanogaster
FBpp0074841	Q9VVU5	Drosophila melanogaster
FBpp0089195	Q94899	Drosophila melanogaster
FBpp0083687	Q9V3G7	Drosophila melanogaster
FBpp0086604	Q7KLV9	Drosophila melanogaster
FBpp0087935	Q9V345	Drosophila melanogaster
FBpp0083861	Q7KMP8	Drosophila melanogaster
FBpp0077927	Q8SYG2	Drosophila melanogaster
FBpp0078278	Q9V3Z4	Drosophila melanogaster
FBpp0075104	O77410	Drosophila melanogaster
FBpp0086705	Q7JVI3	Drosophila melanogaster
FBpp0078584	Q9VN25	Drosophila melanogaster
FBpp0075833	Q9VTL1	Drosophila melanogaster
FBpp0291495	P25161	Drosophila melanogaster
FBpp0277400	Q292J2	Drosophila pseudoobscura
FBpp0282164	B5DYB0	Drosophila pseudoobscura
FBpp0274175	Q2LZ67	Drosophila pseudoobscura
FBpp0274880	Q2M153	Drosophila pseudoobscura
FBpp0276360	Q28Z41	Drosophila pseudoobscura
FBpp0276783	B5E078	Drosophila pseudoobscura
FBpp0276999	Q292F0	Drosophila pseudoobscura
FBpp0277681	Q290Y3	Drosophila pseudoobscura
FBpp0279146	Q29PI4	Drosophila pseudoobscura
FBpp0283940	Q298U4	Drosophila pseudoobscura
FBpp0284180	Q297K5	Drosophila pseudoobscura
FBpp0285645	Q29JS0	Drosophila pseudoobscura
FBpp0286137	Q29DK4	Drosophila pseudoobscura
FBpp0286544	Q29EX2	Drosophila pseudoobscura
FBpp0284614	Q295G5	Drosophila pseudoobscura

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