modENCODE |  Help |  blog

Protein Domain : IPR016232

Name  cGMP-dependent protein kinase Short Name  cGMP-dependent_protein_kinase
Type  Family Description  Guanosine cyclase 3',5'-dependent protein kinases are known to play a role in smooth muscle relaxation, ion fluxes in kidneys and intestines, and neuronal function. The predominant form of cGMP-dependent protein kinase is a dimer of identical 75 kDa subunits, although larger subunits of 86 and 130 kDa have been found []. The enzyme is kept in an inactive form by the interaction of the catalytic domain of one subunit with the region on the other subunit that precedes the cGMP binding domain. Each subunit contains two cGMP-binding regions, found together in the sequence: binding of two molecules of cGMP precipitates a conformational change in the active site that allows the substrate to bind.Although cGMP- and cAMP-dependent protein kinases are similar both in structure and sequence around the nucleotide binding site, and in the method of activation and inactivation, there are some basic contrasts. The major difference is that all of the functional domains of the cGMP- dependent enzymes are found on a single polypeptide chain, whereas cAMP- dependent protein kinases have separate regulatory (cAMP binding) and catalytic chains.This entry includes cGMP-dependent protein kinases.

Publication Counts Displayer

0 Child Features

10 Contains

DB identifier Name Short Name Type
IPR014710 RmlC-like jelly roll fold RmlC-like_jellyroll Domain
IPR011009 Protein kinase-like domain Kinase-like_dom Domain
IPR000719 Protein kinase domain Prot_kinase_dom Domain
IPR017441 Protein kinase, ATP binding site Protein_kinase_ATP_BS Binding_site
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain Ser/Thr_dual-sp_kinase_dom Domain
IPR008271 Serine/threonine-protein kinase, active site Ser/Thr_kinase_AS Active_site
IPR000961 AGC-kinase, C-terminal AGC-kinase_C Domain
IPR018490 Cyclic nucleotide-binding-like cNMP-bd-like Domain
IPR018488 Cyclic nucleotide-binding, conserved site cNMP-bd_CS Conserved_site
IPR000595 Cyclic nucleotide-binding domain cNMP-bd_dom Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PIRSF000559 PIRSF IPR016232

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

0 Found In

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
cGMP-dependent protein kinase   GO:0004692 cGMP-dependent protein kinase activity

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
cGMP-dependent protein kinase   GO:0004692 cGMP-dependent protein kinase activity

1 Parent Features

DB identifier Name Short Name Type
IPR002374 cGMP-dependent kinase cGMP_dep_kinase Family

15 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0077706 Q03042 Drosophila melanogaster
FBpp0280813 Q29LM5 Drosophila pseudoobscura
FBpp0234069 B4LTP9 Drosophila virilis
FBpp0260952 B4P2X2 Drosophila yakuba
EGL4_CAEBR A8X6H1 Caenorhabditis briggsae
K7H5C6_CAEJA K7H5C6 Caenorhabditis japonica
G0NYC3_CAEBE G0NYC3 Caenorhabditis brenneri
EGL4_CAEEL O76360 Caenorhabditis elegans
EGL4_CAEEL-4 O76360-4 Caenorhabditis elegans
EGL4_CAEEL-3 O76360-3 Caenorhabditis elegans
EGL4_CAEEL-2 O76360-2 Caenorhabditis elegans
EGL4_CAEEL-6 O76360-6 Caenorhabditis elegans
EGL4_CAEEL-5 O76360-5 Caenorhabditis elegans
U4PEQ9_CAEEL U4PEQ9 Caenorhabditis elegans
E1U3F9_DROME E1U3F9 Drosophila melanogaster