modENCODE |  Help |  blog

Protein Domain : IPR015880

Name  Zinc finger, C2H2-like Short Name  Znf_C2H2-like
Type  Domain Description  Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis(African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. C2H2-type (classical) zinc fingers (Znf) were the first class to be characterised. They contain a short beta hairpin and an alpha helix (beta/beta/alpha structure), where a single zinc atom is held in place by Cys(2)His(2) (C2H2) residues in a tetrahedral array. C2H2 Znf's can be divided into three groups based on the number and pattern of fingers: triple-C2H2 (binds single ligand), multiple-adjacent-C2H2 (binds multiple ligands), and separated paired-C2H2 []. C2H2 Znf's are the most common DNA-binding motifs found in eukaryotic transcription factors, and have also been identified in prokaryotes []. Transcription factors usually contain several Znf's (each with a conserved beta/beta/alpha structure) capable of making multiple contacts along the DNA, where the C2H2 Znf motifs recognise DNA sequences by binding to the major groove of DNA via a short alpha-helix in the Znf, the Znf spanning 3-4 bases of the DNA []. C2H2 Znf's can also bind to RNA and protein targets [].This entry represents zinc finger domains resembling the C2H2-type.

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR007087 Zinc finger, C2H2 Znf_C2H2 Domain

2 Contains

DB identifier Name Short Name Type
IPR000690 Zinc finger, C2H2-type matrin Znf_C2H2_matrin Domain
IPR015318 Zinc finger, GAGA-binding factor Znf_GAGA-bd_fac Domain

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
SM00355 SMART IPR015880

2 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  

11 Found In

DB identifier Name Short Name Type
IPR003604 Zinc finger, U1-type Znf_U1 Domain
IPR007042 Arsenite-resistance protein 2 Arsenite-R_2 Domain
IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain Znf_C2H2/integrase_DNA-bd Domain
IPR004595 TFIIH C1-like domain TFIIH_C1-like_dom Domain
IPR012170 TFIIH subunit Ssl1/p44 TFIIH_SSL1/p44 Family
IPR009170 Predicted retinoblastoma binding protein (RIZ) RIZ_retinblastoma-bd_prot Family
IPR019485 Zinc finger, V(D)J recombination-activating protein 1 Znf_VDJ_recomb-activ_1 Domain
IPR007071 A-kinase anchoring protein 95 (AKAP95) AKAP95 Family
IPR012866 Protein of unknown function DUF1644 DUF1644 Family
IPR022698 Protein of unknown function DUF3505 DUF3505 Family
IPR006865 Domain of unknown function DUF629 DUF629 Domain

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3783 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0088052 Q1LZ24 Drosophila melanogaster
FBpp0087331 Q7JW60 Drosophila melanogaster
FBpp0077247 Q9VQS7 Drosophila melanogaster
FBpp0087330 Q7JQY8 Drosophila melanogaster
FBpp0083174 Q8MSG8 Drosophila melanogaster
FBpp0099541 Q7KAH0 Drosophila melanogaster
FBpp0305260 M9PFM7 Drosophila melanogaster
FBpp0099866 A4V1Y7 Drosophila melanogaster
FBpp0089417 A4V1Y6 Drosophila melanogaster
FBpp0305259 Q2PDY1 Drosophila melanogaster
FBpp0099867 Q2PDY2 Drosophila melanogaster
FBpp0074392 Q9VWT2 Drosophila melanogaster
FBpp0073022 Q9VZK2 Drosophila melanogaster
FBpp0081613 Q9VH70 Drosophila melanogaster
FBpp0081832 Q9VGQ5 Drosophila melanogaster
FBpp0288841 Q7KSP9 Drosophila melanogaster
FBpp0081490 Q9VHJ3 Drosophila melanogaster
FBpp0076388 Q95U58 Drosophila melanogaster
FBpp0073882 Q9VXT1 Drosophila melanogaster
FBpp0301059 R9PY46 Drosophila melanogaster
FBpp0290458 A8JV12 Drosophila melanogaster
FBpp0290459 A8JV11 Drosophila melanogaster
FBpp0072245 Q9W137 Drosophila melanogaster
FBpp0292193 S0ARU4 Drosophila melanogaster
FBpp0112237 Q8IRV4 Drosophila melanogaster
FBpp0070521 Q9W4V2 Drosophila melanogaster
FBpp0080198 Q9VJT3 Drosophila melanogaster
FBpp0070870 Q9W403 Drosophila melanogaster
FBpp0085079 Q86PF2 Drosophila melanogaster
FBpp0110305 Q7YU81 Drosophila melanogaster