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Protein Domain : IPR015727

Name  Protein kinase C mu-related Short Name  Protein_Kinase_C_mu-related
Type  Family Description  Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].The protein kinase D family of enzymes consists of three isoforms: PKD1 (PKCmu), PKD2, and PKD3 (PKCnu). They all share a similar architecture with regulatory sub-domains that play specific roles in the activation, translocation and function of the enzymes. The PKD enzymes have recently been implicated in very diverse cellular functions, including Golgi organisation and plasma membrane directed transport, metastasis, immune responses, apoptosis and cell proliferation [].

Publication Counts Displayer

0 Child Features

7 Contains

DB identifier Name Short Name Type
IPR017441 Protein kinase, ATP binding site Protein_kinase_ATP_BS Binding_site
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain Ser/Thr_dual-sp_kinase_dom Domain
IPR008271 Serine/threonine-protein kinase, active site Ser/Thr_kinase_AS Active_site
IPR011993 Pleckstrin homology-like domain PH_like_dom Domain
IPR001849 Pleckstrin homology domain Pleckstrin_homology Domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding Prot_Kinase_C-like_PE/DAG-bd Domain
IPR020454 Diacylglycerol/phorbol-ester binding DAG/PE-bd Domain

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PTHR22968 PANTHER IPR015727
PIRSF000552 PIRSF IPR015727

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

0 Found In

3 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Protein kinase C mu-related   GO:0004697 protein kinase C activity
Protein kinase C mu-related   GO:0005524 ATP binding
Protein kinase C mu-related   GO:0006468 protein phosphorylation

3 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Protein kinase C mu-related   GO:0004697 protein kinase C activity
Protein kinase C mu-related   GO:0005524 ATP binding
Protein kinase C mu-related   GO:0006468 protein phosphorylation

0 Parent Features

44 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0083010 Q9VE91 Drosophila melanogaster
FBpp0283812 B5DY27 Drosophila pseudoobscura
FBpp0173485 B4K940 Drosophila mojavensis
FBpp0225257 B4M405 Drosophila virilis
FBpp0270220 B4PLA9 Drosophila yakuba
DKF1_CAEBR A8XWC4 Caenorhabditis briggsae
DKF2_CAEBR A8XQD5 Caenorhabditis briggsae
A8X0D8_CAEBR A8X0D8 Caenorhabditis briggsae
A8X0D9_CAEBR A8X0D9 Caenorhabditis briggsae
K7GUW8_CAEJA K7GUW8 Caenorhabditis japonica
H2W0C0_CAEJA H2W0C0 Caenorhabditis japonica
K7HMI2_CAEJA K7HMI2 Caenorhabditis japonica
K7GUW9_CAEJA K7GUW9 Caenorhabditis japonica
K7I815_CAEJA K7I815 Caenorhabditis japonica
K7GVM6_CAEJA K7GVM6 Caenorhabditis japonica
K7GVM7_CAEJA K7GVM7 Caenorhabditis japonica
K7HMI3_CAEJA K7HMI3 Caenorhabditis japonica
K7GVV7_CAEJA K7GVV7 Caenorhabditis japonica
K7GVV9_CAEJA K7GVV9 Caenorhabditis japonica
G0P3F1_CAEBE G0P3F1 Caenorhabditis brenneri
G0P3F2_CAEBE G0P3F2 Caenorhabditis brenneri
G0NFP9_CAEBE G0NFP9 Caenorhabditis brenneri
G0NPG4_CAEBE G0NPG4 Caenorhabditis brenneri
G0N0Q2_CAEBE G0N0Q2 Caenorhabditis brenneri
G0N0Q3_CAEBE G0N0Q3 Caenorhabditis brenneri
DKF1_CAEEL Q9XUJ7 Caenorhabditis elegans
DKF2_CAEEL O45818 Caenorhabditis elegans
DKF2_CAEEL-6 O45818-6 Caenorhabditis elegans
DKF2_CAEEL-5 O45818-5 Caenorhabditis elegans
DKF2_CAEEL-4 O45818-4 Caenorhabditis elegans