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Protein Domain : IPR002219

Name  Protein kinase C-like, phorbol ester/diacylglycerol binding Short Name  Prot_Kinase_C-like_PE/DAG-bd
Type  Domain Description  Diacylglycerol (DAG) is an important second messenger. Phorbol esters (PE) are analogues of DAG and potent tumour promoters that cause a variety of physiological changes when administered to both cells and tissues. DAG activates a family of serine/threonine protein kinases, collectively known as protein kinase C (PKC) []. Phorbol esters can directly stimulate PKC. The N-terminal region of PKC, known as C1, has been shown []to bind PE and DAG in a phospholipid and zinc-dependent fashion. The C1 region contains one or two copies (depending on the isozyme of PKC) of a cysteine-rich domain, which is about 50 amino-acid residues long, and which is essential for DAG/PE-binding. The DAG/PE-binding domain binds two zinc ions; the ligands of these metal ions are probably the six cysteines and two histidines that are conserved in this domain.

Publication Counts Displayer

0 Child Features

0 Contains

4 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00130 PFAM IPR002219
PS00479 PROSITE IPR002219
PS50081 PROFILE IPR002219
SM00109 SMART IPR002219

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

9 Found In

DB identifier Name Short Name Type
IPR015727 Protein kinase C mu-related Protein_Kinase_C_mu-related Family
IPR020454 Diacylglycerol/phorbol-ester binding DAG/PE-bd Domain
IPR012233 Protein kinase C, zeta/iota PKC_zeta Family
IPR014376 Protein kinase C, delta/epsilon/eta/theta types Prot_kin_PKC_delta Family
IPR015721 Rho GTP exchange factor RhoGEF-like Family
IPR017356 N-chimaerin N-chimaerin Family
IPR014375 Protein kinase C, alpha/beta/gamma types Protein_kinase_C_a/b/g Family
IPR020684 Rho-associated protein kinase Rho-assoc_coiled-coil_kin Family
IPR017405 Citron Rho-interacting kinase Citron_Rho-interacting_kinase Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Protein kinase C-like, phorbol ester/diacylglycerol binding   GO:0035556 intracellular signal transduction

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
Protein kinase C-like, phorbol ester/diacylglycerol binding   GO:0035556 intracellular signal transduction

0 Parent Features

455 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086123 A1ZAN7 Drosophila melanogaster
FBpp0086124 A1ZAN6 Drosophila melanogaster
FBpp0072194 Q9W1B0 Drosophila melanogaster
FBpp0305901 M9PHJ6 Drosophila melanogaster
FBpp0074448 Q9NHV9 Drosophila melanogaster
FBpp0112228 A8JUQ9 Drosophila melanogaster
FBpp0290731 Q4QQA3 Drosophila melanogaster
FBpp0075702 Q9VTY8 Drosophila melanogaster
FBpp0083010 Q9VE91 Drosophila melanogaster
FBpp0075727 Q9VTT9 Drosophila melanogaster
FBpp0086196 P13677 Drosophila melanogaster
FBpp0099675 Q7YTZ4 Drosophila melanogaster
FBpp0088306 Q9V483 Drosophila melanogaster
FBpp0111731 A8DYG9 Drosophila melanogaster
FBpp0086197 P05130 Drosophila melanogaster
FBpp0085772 Q0E919 Drosophila melanogaster
FBpp0085770 A1ZBH5 Drosophila melanogaster
FBpp0088307 Q8IM86 Drosophila melanogaster
FBpp0088305 Q8IM87 Drosophila melanogaster
FBpp0081099 P40809 Drosophila melanogaster
FBpp0070385 P11346 Drosophila melanogaster
FBpp0083885 Q9VCF2 Drosophila melanogaster
FBpp0083886 Q7KS35 Drosophila melanogaster
FBpp0082003 Q9VGH9 Drosophila melanogaster
FBpp0082004 Q7KSP6 Drosophila melanogaster
FBpp0074061 Q9VXE3 Drosophila melanogaster
FBpp0071672 Q9W293 Drosophila melanogaster
FBpp0300963 H9XVP2 Drosophila melanogaster
FBpp0306555 L0MPR2 Drosophila melanogaster
FBpp0086966 Q7K579 Drosophila melanogaster