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Protein Domain : IPR011992

Name  EF-hand domain pair Short Name  EF-hand-dom_pair
Type  Domain Description  This domain consists of a duplication of two EF-hand units, where each unit is composed of two helices connected by a twelve-residue calcium-binding loop. The calcium ion in the EF-hand loop is coordinated in a pentagonal bipyramidal configuration. Many calcium-binding proteins contain an EF-hand type calcium-binding domain [, ]. These include: calbindin D9K, S100 proteins such as calcyclin, polcalcin phl p 7 (a calcium-binding pollen allergen), osteonectin, parvalbumin, calmodulin []family of proteins (troponin C, caltractin, cdc4p, myosin essential chain, calcineurin, recoverin, neurocalcin), plasmodial-specific CaII-binding protein Cbp40, penta-EF-Hand proteins [](sorcin, grancalcin, calpain), as well as multidomain proteins such as phosphoinositide-specific phospholipase C, dystrophin, Cb1 and alpha-actinin. The fold consists of four helices and an open array of two hairpins.

Publication Counts Displayer

3 Child Features

DB identifier Name Short Name Type
IPR019577 SPARC/Testican, calcium-binding domain SPARC/Testican_Ca-bd-dom Domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like PLipase_C_EF-hand-like Domain
IPR014741 Adaptor protein Cbl, EF hand-like Adaptor_Cbl_EF_hand-like Domain

11 Contains

DB identifier Name Short Name Type
IPR018247 EF-Hand 1, calcium-binding site EF_Hand_1_Ca_BS Binding_site
IPR002048 EF-hand domain EF_hand_dom Domain
IPR013566 EF hand associated,type-1 EF_hand_assoc_1 Domain
IPR013567 EF hand associated, type-2 EF_hand_assoc_2 Domain
IPR001999 Osteonectin-like, conserved site Osteonectin_CS Conserved_site
IPR014837 EF-hand, Ca insensitive EF-hand_Ca_insen Domain
IPR015153 EF-hand domain, type 1 EF-hand_dom_typ1 Domain
IPR015154 EF-hand domain, type 2 EF-hand_dom_typ2 Domain
IPR013787 S100/CaBP-9k-type, calcium binding, subdomain S100_Ca-bd_sub Domain
IPR013623 NADPH oxidase Respiratory burst NADPH_Ox Domain
IPR001751 S100/Calbindin-D9k, conserved site S100/CaBP-9k_CS Conserved_site

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF13499 PFAM IPR011992
G3DSA:1.10.238.10 GENE3D IPR011992

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

10 Found In

DB identifier Name Short Name Type
IPR001217 Transcription factor STAT STAT Family
IPR013801 STAT transcription factor, DNA-binding STAT_TF_DNA-bd Domain
IPR013333 Ryanodine receptor Ryan_recept Family
IPR017432 Distrobrevin Distrobrevin Family
IPR016359 SPARC-like protein 1 SPARC-like_p1 Family
IPR015757 Calcineurin B protein Calcineur_B Family
IPR015754 Calcium binding protein 2 Ca-bd_2 Family
IPR015756 Guanylate cyclase activating protein 2 GCAP-2 Family
IPR008080 Parvalbumin Parvalbumin Family
IPR016344 Dystrophin/utrophin Dystrophin/utrophin Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
EF-hand domain pair   GO:0005509 calcium ion binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
EF-hand domain pair   GO:0005509 calcium ion binding

0 Parent Features

1281 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0071789 Q9W200 Drosophila melanogaster
FBpp0074319 P37236 Drosophila melanogaster
FBpp0074320 Q9VWX8 Drosophila melanogaster
FBpp0087930 A1Z777 Drosophila melanogaster
FBpp0080727 Q9VJ26 Drosophila melanogaster
FBpp0072596 Q9W0E9 Drosophila melanogaster
FBpp0078699 Q9VMT2 Drosophila melanogaster
FBpp0078670 Q7K1W8 Drosophila melanogaster
FBpp0305719 M9PC74 Drosophila melanogaster
FBpp0086204 P41044 Drosophila melanogaster
FBpp0291176 E1JH64 Drosophila melanogaster
FBpp0071498 Q9W2L0 Drosophila melanogaster
FBpp0303430 M9PHN1 Drosophila melanogaster
FBpp0073824 Q24175 Drosophila melanogaster
FBpp0082157 Q9VG26 Drosophila melanogaster
FBpp0072223 Q9W139 Drosophila melanogaster
FBpp0083149 Q9VDY9 Drosophila melanogaster
FBpp0309697 Q9V3V2 Drosophila melanogaster
FBpp0110252 Q0KI91 Drosophila melanogaster
FBpp0082263 Q9VFT7 Drosophila melanogaster
FBpp0083980 Q8IMX7 Drosophila melanogaster
FBpp0076341 O46034 Drosophila melanogaster
FBpp0076342 Q9VSK2 Drosophila melanogaster
FBpp0072340 Q9W111 Drosophila melanogaster
FBpp0072339 Q8MMD2 Drosophila melanogaster
FBpp0072338 Q8MMD3 Drosophila melanogaster
FBpp0300890 E3CTP7 Drosophila melanogaster
FBpp0074418 Q9VWN5 Drosophila melanogaster
FBpp0070176 Q8SYN0 Drosophila melanogaster
FBpp0087981 A1Z707 Drosophila melanogaster