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Protein Domain : IPR021133

Name  HEAT, type 2 Short Name  HEAT_type_2
Type  Repeat Description  The HEAT repeat is a tandemly repeated, 37-47 amino acid long moduleoccurring in a number of cytoplasmic proteins, including the fourname-giving proteins huntingtin, elongation factor 3 (EF3), the 65 Kdalpha regulatory subunit of protein phosphatase 2A (PP2A) and theyeast PI3-kinase TOR1 []. Arrays of HEAT repeats consists of 3 to 36units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that manyHEAT repeat-containing proteins are involved in intracellular transport processes.In the crystal structure of PP2A PR65/A [], the HEAT repeats consistof pairs of antiparallel alpha helices [].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PS50077 PROFILE IPR021133

2 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  

2 Found In

DB identifier Name Short Name Type
IPR016024 Armadillo-type fold ARM-type_fold Domain
IPR011989 Armadillo-like helical ARM-like Domain

0 GO Annotation

0 Ontology Annotations

0 Parent Features

133 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0088470 Q9NBD7 Drosophila melanogaster
FBpp0099974 P36179 Drosophila melanogaster
FBpp0297239 M9NDI6 Drosophila melanogaster
FBpp0308836 H5V8B8 Drosophila melanogaster
FBpp0085370 A1Z6G6 Drosophila melanogaster
FBpp0080922 O18388 Drosophila melanogaster
FBpp0078500 Q9VN44 Drosophila melanogaster
FBpp0112471 Q7PLL6 Drosophila melanogaster
FBpp0293343 E1JIM4 Drosophila melanogaster
FBpp0290695 Q9VEZ3 Drosophila melanogaster
FBpp0288337 Q29F41 Drosophila pseudoobscura
FBpp0301268 I5APP2 Drosophila pseudoobscura
FBpp0287273 B5DK32 Drosophila pseudoobscura
FBpp0279804 Q29LW8 Drosophila pseudoobscura
FBpp0280343 B5DHZ5 Drosophila pseudoobscura
FBpp0281243 Q294U7 Drosophila pseudoobscura
FBpp0281545 Q296D7 Drosophila pseudoobscura
FBpp0302557 I5AP61 Drosophila pseudoobscura
FBpp0162343 B4KUK6 Drosophila mojavensis
FBpp0166569 B4KE78 Drosophila mojavensis
FBpp0166703 B4KFU3 Drosophila mojavensis
FBpp0167389 B4KHT2 Drosophila mojavensis
FBpp0167469 B4KJ03 Drosophila mojavensis
FBpp0171870 B4KAF5 Drosophila mojavensis
FBpp0229034 B4LVD8 Drosophila virilis
FBpp0229494 B4LQR1 Drosophila virilis
FBpp0230569 B4LS97 Drosophila virilis
FBpp0235707 B4LRQ0 Drosophila virilis
FBpp0237438 B4LV89 Drosophila virilis
FBpp0237798 B4LY15 Drosophila virilis