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Protein Domain : IPR000357

Name  HEAT Short Name  HEAT
Type  Repeat Description  The HEAT repeat is a tandemly repeated, 37-47 amino acid long moduleoccurring in a number of cytoplasmic proteins, including the fourname-giving proteins huntingtin, elongation factor 3 (EF3), the 65 Kdalpha regulatory subunit of protein phosphatase 2A (PP2A) and theyeast PI3-kinase TOR1 []. Arrays of HEAT repeats consists of 3 to 36units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that manyHEAT repeat-containing proteins are involved in intracellular transport processes.In the crystal structure of PP2A PR65/A [], the HEAT repeats consistof pairs of antiparallel alpha helices [].

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF02985 PFAM IPR000357

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

3 Found In

DB identifier Name Short Name Type
IPR016024 Armadillo-type fold ARM-type_fold Domain
IPR011989 Armadillo-like helical ARM-like Domain
IPR000091 Huntingtin Huntingtin Family

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
HEAT   GO:0005515 protein binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
HEAT   GO:0005515 protein binding

0 Parent Features

50 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0082148 Q9VG59 Drosophila melanogaster
FBpp0099974 P36179 Drosophila melanogaster
FBpp0071178 Q9W3E1 Drosophila melanogaster
FBpp0305180 Q9W437 Drosophila melanogaster
FBpp0297239 M9NDI6 Drosophila melanogaster
FBpp0308836 H5V8B8 Drosophila melanogaster
FBpp0078500 Q9VN44 Drosophila melanogaster
FBpp0112471 Q7PLL6 Drosophila melanogaster
FBpp0281545 Q296D7 Drosophila pseudoobscura
FBpp0166569 B4KE78 Drosophila mojavensis
FBpp0230569 B4LS97 Drosophila virilis
FBpp0231156 B4M840 Drosophila virilis
FBpp0261494 B4PYP0 Drosophila yakuba
FBpp0263771 B4NWX2 Drosophila yakuba
FBpp0270440 B4PUF9 Drosophila yakuba
CLAP1_CAEBR Q61KX5 Caenorhabditis briggsae
A8WZC4_CAEBR A8WZC4 Caenorhabditis briggsae
A8Y1F9_CAEBR A8Y1F9 Caenorhabditis briggsae
H2W6L9_CAEJA H2W6L9 Caenorhabditis japonica
K7H2I0_CAEJA K7H2I0 Caenorhabditis japonica
K7H7Z5_CAEJA K7H7Z5 Caenorhabditis japonica
K7I6V8_CAEJA K7I6V8 Caenorhabditis japonica
K7H7S4_CAEJA K7H7S4 Caenorhabditis japonica
K7H7Z4_CAEJA K7H7Z4 Caenorhabditis japonica
K7H7S3_CAEJA K7H7S3 Caenorhabditis japonica
H2WAX8_CAEJA H2WAX8 Caenorhabditis japonica
K7I6V9_CAEJA K7I6V9 Caenorhabditis japonica
K7H2I1_CAEJA K7H2I1 Caenorhabditis japonica
G0P1P6_CAEBE G0P1P6 Caenorhabditis brenneri
G0MPQ0_CAEBE G0MPQ0 Caenorhabditis brenneri