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Protein Domain : IPR011511

Name  Variant SH3 domain Short Name  SH3_2
Type  Domain Description  SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues [, ]. They are found in a great variety of intracellular or membrane-associated proteins [, , ]for example, in a variety of proteins with enzymatic activity, in adaptor proteins, such as fodrin and yeast actin binding protein ABP-1.The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices []. The surface of the SH3-domain bears a flat, hydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions. The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins, altering their subcellular location and mediating the assembly of large multiprotein complexes [].This entry represents a variant of the SH3 domain.

Publication Counts Displayer

0 Child Features

0 Contains

1 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF07653 PFAM IPR011511

2 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  

3 Found In

DB identifier Name Short Name Type
IPR001452 SH3 domain SH3_domain Domain
IPR014593 Uncharacterised conserved protein UCP034961, SH3-2 UCP034961_SH3_2 Family
IPR005420 Zona occludens protein ZO-3 ZonOcculS3 Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

209 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0293362 Q86BP0 Drosophila melanogaster
FBpp0083595 Q8SZS0 Drosophila melanogaster
FBpp0290250 Q0KI30 Drosophila melanogaster
FBpp0303361 Q9I7F7 Drosophila melanogaster
FBpp0293363 Q9VF66 Drosophila melanogaster
FBpp0293364 Q86BS0 Drosophila melanogaster
FBpp0300576 H9XVM6 Drosophila melanogaster
FBpp0088182 Q9XYM0 Drosophila melanogaster
FBpp0088183 Q95RW2 Drosophila melanogaster
FBpp0306509 E8NH51 Drosophila melanogaster
FBpp0087292 A1Z8G0 Drosophila melanogaster
FBpp0113062 B7YZF0 Drosophila melanogaster
FBpp0113061 Q8T5S9 Drosophila melanogaster
FBpp0088913 Q9W3H7 Drosophila melanogaster
FBpp0099784 Q6NR03 Drosophila melanogaster
FBpp0088912 Q7KVT3 Drosophila melanogaster
FBpp0088916 Q9W3H6 Drosophila melanogaster
FBpp0110333 Q0KHU9 Drosophila melanogaster
FBpp0111740 E2QD98 Drosophila melanogaster
FBpp0086727 A1Z9K8 Drosophila melanogaster
FBpp0111785 A8JR71 Drosophila melanogaster
FBpp0083559 Q24210 Drosophila melanogaster
FBpp0300538 M9NG38 Drosophila melanogaster
FBpp0300537 Q9W3H8 Drosophila melanogaster
FBpp0300540 M9NEZ2 Drosophila melanogaster
FBpp0290542 E1JIS7 Drosophila melanogaster
FBpp0111786 A8JR72 Drosophila melanogaster
FBpp0293837 Q8MQQ3 Drosophila melanogaster
FBpp0293840 Q9VHK3 Drosophila melanogaster
FBpp0293839 Q8INQ0 Drosophila melanogaster