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Protein Domain : IPR000980

Name  SH2 domain Short Name  SH2
Type  Domain Description  The Src homology 2 (SH2) domain is a protein domain of about 100 amino-acid residues first identified as a conserved sequence region between the oncoproteins Src and Fps []. Similar sequences were later found in many other intracellular signal-transducing proteins []. SH2 domains function as regulatory modules of intracellular signalling cascades by interacting with high affinity to phosphotyrosine-containing target peptides in a sequence-specific, SH2 domains recognise between 3-6 residues C-terminal to the phosphorylated tyrosine in a fashion that differs from one SH2 domain to another, and strictly phosphorylation-dependent manner [, , , ]. They are found in a wide variety of protein contexts e.g., in association with catalytic domains of phospholipase Cy (PLCy) and the non-receptor protein tyrosine kinases; within structural proteins such as fodrin and tensin; and in a group of small adaptor molecules, i.e Crk and Nck. The domains are frequently found as repeats in a single protein sequence and will then often bind both mono- and di-phosphorylated substrates. The structure of the SH2 domain belongs to the alpha+beta class, its overall shape forming a compact flattened hemisphere. The core structural elements comprise a central hydrophobic anti-parallel beta-sheet, flanked by 2 short alpha-helices. The loop between strands 2 and 3 provides many of the binding interactions with the phosphate group of its phosphopeptide ligand, and is hence designated the phosphate binding loop, the phosphorylated ligand binds perpendicular to the beta-sheet and typically interacts with the phosphate binding loop and a hydrophobic binding pocket that interacts with a pY+3 side chain. The N- and C-termini of the domain are close together in space and on the opposite face from the phosphopeptide binding surface and it has been speculated that this has facilitated their integration into surface-exposed regions of host proteins [].

Publication Counts Displayer

1 Child Features

DB identifier Name Short Name Type
IPR014742 Adaptor protein Cbl, SH2-like Adaptor_Cbl_SH2-like Domain

0 Contains

7 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00017 PFAM IPR000980
PF14633 PFAM IPR000980
PR00401 PRINTS IPR000980
PS50001 PROFILE IPR000980
SM00252 SMART IPR000980
G3DSA:3.30.505.10 GENE3D IPR000980
SSF55550 SSF IPR000980

3 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  
InterPro GO Annotation data set  

14 Found In

DB identifier Name Short Name Type
IPR017072 Transcription elongation factor Spt6 TF_Spt6 Family
IPR001217 Transcription factor STAT STAT Family
IPR017304 Cytoplasmic protein NCK NCK Family
IPR001720 PI3 kinase, P85 regulatory subunit PI3kinase_P85 Family
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma PLC-gamma Family
IPR017356 N-chimaerin N-chimaerin Family
IPR012152 Protein-tyrosine phosphatase, non-receptor type-6, -11 Tyr_Pase_non-rcpt_typ-6/11 Family
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2 Tyr_kinase_non-rcpt_Jak/Tyk2 Family
IPR020693 Tyrosine-protein kinase, non-receptor Jak2 Tyr_kinase_non-rcpt_Jak2 Family
IPR020775 Tyrosine-protein kinase, non-receptor Jak3 Tyr_kinase_non-rcpt_Jak3 Family
IPR020776 Tyrosine-protein kinase, non-receptor Jak1 Tyr_kinase_non-rcpt_Jak1 Family
IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70 Tyr_kinase_non-rcpt_SYK/ZAP70 Family
IPR016250 Tyrosine-protein kinase, Fes/Fps type Tyr-prot_kinase_Fes/Fps Family
IPR016045 Tyrosine-protein kinase, non-receptor, TYK2, N-terminal Tyr_kinase_non-rcpt_TYK2_N Domain

1 GO Annotation


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
SH2 domain   GO:0005515 protein binding

1 Ontology Annotations


Subject . Secondary Identifier

Subject . Name

Subject . Symbol

Ontology Term . Identifier

Ontology Term . Name
SH2 domain   GO:0005515 protein binding

0 Parent Features

628 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0099403 Q6NR09 Drosophila melanogaster
FBpp0290256 Q29QP1 Drosophila melanogaster
FBpp0099944 P00528 Drosophila melanogaster
FBpp0089147 Q8IR23 Drosophila melanogaster
FBpp0305901 M9PHJ6 Drosophila melanogaster
FBpp0074448 Q9NHV9 Drosophila melanogaster
FBpp0112228 A8JUQ9 Drosophila melanogaster
FBpp0078860 Q8T010 Drosophila melanogaster
FBpp0078859 Q9VMJ4 Drosophila melanogaster
FBpp0076341 O46034 Drosophila melanogaster
FBpp0076342 Q9VSK2 Drosophila melanogaster
FBpp0081597 Q9VHC3 Drosophila melanogaster
FBpp0307254 Q9V9J3 Drosophila melanogaster
FBpp0076778 Q9VRR9 Drosophila melanogaster
FBpp0305359 Q9VYM1 Drosophila melanogaster
FBpp0305358 Q7KV33 Drosophila melanogaster
FBpp0305357 M9PEE4 Drosophila melanogaster
FBpp0070363 L7XAI0 Drosophila melanogaster
FBpp0077680 Q9VPU1 Drosophila melanogaster
FBpp0077678 Q8IPW2 Drosophila melanogaster
FBpp0086382 Q24145 Drosophila melanogaster
FBpp0084309 Q7K137 Drosophila melanogaster
FBpp0300576 H9XVM6 Drosophila melanogaster
FBpp0088182 Q9XYM0 Drosophila melanogaster
FBpp0088183 Q95RW2 Drosophila melanogaster
FBpp0293411 H9XVM7 Drosophila melanogaster
FBpp0081530 P18106 Drosophila melanogaster
FBpp0073313 Q24592 Drosophila melanogaster
FBpp0070861 Q9W420 Drosophila melanogaster
FBpp0087862 Q7JVF1 Drosophila melanogaster