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Protein Domain : IPR013032

Name  EGF-like, conserved site Short Name  EGF-like_CS
Type  Conserved_site Description  A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF)has been shown [, , , , ]to be present, in a moreor less conserved form, in a large number of other, mostly animal proteins. The list of proteins currently known tocontain one or more copies of an EGF-like pattern is large and varied. The functional significance of EGF domains inwhat appear to be unrelated proteins is not yet clear. However, a common feature is that these repeats are found inthe extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandinG/H synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in disulphidebonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet.Subdomains between the conserved cysteines vary in length.This entry represents a conserved site in the EGF-like domain.

Publication Counts Displayer

0 Child Features

0 Contains

3 Cross References

Source . Name

Subject . Primary Identifier
PF12661 PFAM IPR013032
PS00022 PROSITE IPR013032
PS01186 PROSITE IPR013032

2 Data Sets

Name URL
Swiss-Prot data set
InterPro data set  

29 Found In

DB identifier Name Short Name Type
IPR000742 Epidermal growth factor-like domain EG-like_dom Domain
IPR002049 EGF-like, laminin EGF_laminin Domain
IPR017050 Peptidase M12A, astacin, nematode Peptidase_M12A_nem Family
IPR001881 EGF-like calcium-binding domain EGF-like_Ca-bd_dom Domain
IPR015812 Integrin beta subunit Integrin_bsu Family
IPR013111 EGF-like domain, extracellular EGF_extracell Domain
IPR015446 Bone morphogenetic protein 1/tolloid-like protein BMP_1/tolloid-like Family
IPR008297 Notch Notch Family
IPR012111 Hemolectin/hemocytin Hml Family
IPR011398 Fibrillin/Microneme protein4 FBN/EtMIC4 Family
IPR017048 Fibulin-1 Fibulin-1 Family
IPR001491 Thrombomodulin Thrombomodulin Family
IPR011170 Growth factor, vaccinia C11R type GF_C11R Family
IPR015455 Thrombospondin-2 Thrombospondin-2 Family
IPR015442 Integrin beta-8 subunit Integrin_bsu-8 Family
IPR015497 Epidermal growth factor receptor ligand EGF_rcpt_ligand Family
IPR022355 Neurogenic locus Notch 4 Notch_4 Family
IPR016317 Pro-epidermal growth factor Pro-epidermal_GF Family
IPR018250 Neuregulin Neuregulin Family
IPR012013 Integrin beta-4 subunit Integrin_bsu-4 Family
IPR017047 Teratocarcinoma-derived growth factor Cripto Cripto_growth_factor Family
IPR017369 SPAN protein/blastula protease 10 SPAN/blastula_protease_10 Family
IPR015149 Thrombomodulin-like, EGF-like Tme5_EGF-like Domain
IPR016316 Complement component C1q/Thrombomodulin CD93/CD141 Family
IPR016348 L-selectin L-selectin Family
IPR002396 Selectin superfamily Selectin_superfamily Family
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z Pept_S1A_FX Family
IPR014394 Coagulation factor XIIa/hepatocyte growth factor activator Coagulation_fac_XIIa/HGFA Family
IPR010423 Plasmodium ookinete surface Pvs28 Plasmod_Pvs28 Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

1237 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0293675 M9NE82 Drosophila melanogaster
FBpp0293671 M9NER8 Drosophila melanogaster
FBpp0293672 M9NCR4 Drosophila melanogaster
FBpp0304620 M9PC41 Drosophila melanogaster
FBpp0304623 M9PBZ0 Drosophila melanogaster
FBpp0304622 M9PB30 Drosophila melanogaster
FBpp0304632 M9PB32 Drosophila melanogaster
FBpp0304630 M9PC48 Drosophila melanogaster
FBpp0304631 M9PEI7 Drosophila melanogaster
FBpp0304625 M9PC45 Drosophila melanogaster
FBpp0304626 M9PEI1 Drosophila melanogaster
FBpp0304621 M9PEH5 Drosophila melanogaster
FBpp0304624 M9PCJ6 Drosophila melanogaster
FBpp0304629 M9PCJ8 Drosophila melanogaster
FBpp0304627 M9PB31 Drosophila melanogaster
FBpp0304628 M9PBZ4 Drosophila melanogaster
FBpp0309867 M9MSF5 Drosophila melanogaster
FBpp0070005 Q9W5X1 Drosophila melanogaster
FBpp0292348 E8NH67 Drosophila melanogaster
FBpp0291871 Q8IP51 Drosophila melanogaster
FBpp0293600 R9PY40 Drosophila melanogaster
FBpp0291872 M9MRU0 Drosophila melanogaster
FBpp0070939 Q9W3W5 Drosophila melanogaster
FBpp0079313 P42287 Drosophila melanogaster
FBpp0099719 Q4ABE9 Drosophila melanogaster
FBpp0099718 Q4ABF0 Drosophila melanogaster
FBpp0080568 O15943 Drosophila melanogaster
FBpp0099721 Q4ABE7 Drosophila melanogaster
FBpp0099720 Q4ABE8 Drosophila melanogaster
FBpp0288558 Q9VM55 Drosophila melanogaster