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Protein Domain : IPR006671

Name  Cyclin, N-terminal Short Name  Cyclin_N
Type  Domain Description  Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles [], and regulate cyclin dependent kinases (CDKs). Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins, G1/S cyclins, which are essential for the control of the cell cycle at the G1/S (start) transition, and G2/M cyclins, which are essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase). In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.Cyclin homologues have been found in various viruses, including Saimiriine herpesvirus 2(Herpesvirus saimiri) and Human herpesvirus 8(HHV-8) (Kaposi's sarcoma-associated herpesvirus). These viral homologues differ from their cellular counterparts in that the viral proteins have gained new functions and eliminated others to harness the cell and benefit the virus [].Cyclins contain two domains of similar all-alpha fold, of which this entry is associated with the N-terminal domain.

Publication Counts Displayer

0 Child Features

0 Contains

2 Cross References

Identifier
Source . Name

Subject . Primary Identifier
PF00134 PFAM IPR006671
PS00292 PROSITE IPR006671

2 Data Sets

Name URL
Swiss-Prot data set http://ca.expasy.org/sprot
InterPro data set  

13 Found In

DB identifier Name Short Name Type
IPR013763 Cyclin-like Cyclin-like Domain
IPR015429 Cyclin C/H/T/L Cyclin_C/H/T/L Family
IPR014400 Cyclin A/B/D/E/F Cyclin_A/B/D/E/F Family
IPR015452 Cyclin B3, G2/mitotic-specific Cyclin_B3 Family
IPR012399 Cyclin Y Cyclin_Y Family
IPR012388 Cdk5/c-Abl linker protein Cables Cdk5/c-Abl_linker_Cables Family
IPR015430 Cyclin T Cyclin_T Family
IPR017285 Cyclin, herpesvirus Cyclin_herpesvir Family
IPR015451 Cyclin D Cyclin_D Family
IPR015453 Cyclin A, chordates Cyclin_A_chordates Family
IPR015431 Cyclin L1, chordata Cyclin_L1_chr Family
IPR014399 Cyclin CLN/Puc1 Cyclin_CLN/Puc1 Family
IPR012104 Cyclin Pcl, fungi Cyclin_Pcl_fun Family

0 GO Annotation

0 Ontology Annotations

0 Parent Features

206 Proteins

DB identifier Primary Accession
Organism . Name
FBpp0086798 A1Z9G1 Drosophila melanogaster
FBpp0070418 Q9W526 Drosophila melanogaster
FBpp0074968 O96433 Drosophila melanogaster
FBpp0084103 Q9I7I0 Drosophila melanogaster
FBpp0310472 Q961D1 Drosophila melanogaster
FBpp0080332 P54733 Drosophila melanogaster
FBpp0075808 F3YDG4 Drosophila melanogaster
FBpp0075807 P14785 Drosophila melanogaster
FBpp0078093 O76513 Drosophila melanogaster
FBpp0082469 P25008 Drosophila melanogaster
FBpp0072987 Q9VZP3 Drosophila melanogaster
FBpp0089168 Q95U62 Drosophila melanogaster
FBpp0085163 Q95TJ9 Drosophila melanogaster
FBpp0071822 P20439 Drosophila melanogaster
FBpp0071824 C9QPI9 Drosophila melanogaster
FBpp0305616 Q9VKF0 Drosophila melanogaster
FBpp0293192 M9NFR3 Drosophila melanogaster
FBpp0289621 Q7KUZ5 Drosophila melanogaster
FBpp0306264 Q9VE72 Drosophila melanogaster
FBpp0294012 M9NDQ2 Drosophila melanogaster
FBpp0297955 Q299M1 Drosophila pseudoobscura
FBpp0279691 B5DSP0 Drosophila pseudoobscura
FBpp0277570 Q291N4 Drosophila pseudoobscura
FBpp0283237 B5DY97 Drosophila pseudoobscura
FBpp0274484 Q2M0B7 Drosophila pseudoobscura
FBpp0274646 Q2M0U3 Drosophila pseudoobscura
FBpp0278445 Q28XX0 Drosophila pseudoobscura
FBpp0279733 Q29LM1 Drosophila pseudoobscura
FBpp0279878 B5DIL4 Drosophila pseudoobscura
FBpp0280555 B5DID4 Drosophila pseudoobscura